Macrophage Polarization: Learning to Manage It 3.0

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 311 - 311

Опубликована: Янв. 1, 2025

Macrophages are cells of the innate immune system with very peculiar characteristics, so plastic that they respond rapidly to environmental changes by assuming different and sometimes contrasting functions, such as initiating a physiological inflammatory response or interrupting it repairing damaged tissues [...]

Язык: Английский

---

New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research

Gels, Год журнала: 2025, Номер 11(2), С. 136 - 136

Опубликована: Фев. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Язык: Английский

---

Macrophage polarization regulates the pathogenesis and progression of autoimmune diseases

Autoimmunity Reviews, Год журнала: 2025, Номер 24(7), С. 103820 - 103820

Опубликована: Апрель 21, 2025

Язык: Английский

---

Global, Regional, and National Burden of Aged Rheumatoid Arthritis from 1990–2021, and Projections to 2050: Results from the Global Burden of Disease Study 2021

Опубликована: Янв. 1, 2024

Язык: Английский

---

Exploring molecular mechanism of Panlongqi Tablet (PLQT) against RA: Integrated network pharmacology, molecular docking and experiment validation

International Immunopharmacology, Год журнала: 2024, Номер 144, С. 113639 - 113639

Опубликована: Ноя. 30, 2024

Язык: Английский

---