Liquid Biopsies in the Early Diagnosis, Prognosis, and Tailored Treatment of Colorectal Cancer
Cancers,
Год журнала:
2025,
Номер
17(6), С. 927 - 927
Опубликована: Март 8, 2025
Introduction:
Liquid
biopsies
provide
a
less-invasive
option
to
tissue
for
the
early
diagnosis,
prognosis,
and
tailored
therapy
of
colorectal
cancer
(CRC).
CRC
is
major
cause
cancer-related
death,
identification
essential
improving
patient
outcomes.
Review:
Conventional
diagnostic
techniques,
including
colonoscopy
biopsy,
may
be
enhanced
by
liquid
that
examine
circulating
tumor
cells
(CTCs),
DNA
(ctDNA),
extracellular
vesicles
(EVs),
other
indicators
present
in
body
fluids.
These
markers
significant
insights
into
biology,
heterogeneity,
therapeutic
response.
CTCs
detected
early-stage
have
prognostic
significance
disease
recurrence
survival,
while
ctDNA
investigation
uncover
genetic
mutations,
epigenetic
alterations,
development.
The
minimal
residual
(MRD)
postsurgery
correlates
with
an
elevated
risk
unfavorable
underscoring
its
use
assessing
treatment
effectiveness.
Furthermore,
non-coding
RNAs
(ncRNAs)
contained
inside
EVs
potential
prospective
biomarkers
targets,
facilitating
diagnosis
assessment.
Notwithstanding
biopsies,
obstacles
persist
assay
standardization,
sensitivity
enhancement,
management
heterogeneity.
Additional
extensive
research
required
determine
their
function
clinical
practice.
Conclusion:
Overall,
serve
as
instrument
real-time
monitoring,
evaluating
responses,
directing
individualized
strategies
patients.
Язык: Английский
The crosstalk between lung adenocarcinoma cells and M2 macrophages promotes cancer cell development via the SFRS1/miR-708-5p/PD-L1 axis
Life Sciences,
Год журнала:
2025,
Номер
unknown, С. 123599 - 123599
Опубликована: Апрель 1, 2025
Язык: Английский
LINC01559: roles, mechanisms, and clinical implications in human cancers
Human Cell,
Год журнала:
2025,
Номер
38(3)
Опубликована: Апрель 9, 2025
Язык: Английский
Exosome-based immunotherapy in hepatocellular carcinoma
Clinical and Experimental Medicine,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 24, 2025
Язык: Английский
Baicalin Alleviates Piglet Immunosuppression Induced by Glaesserella parasuis via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy
Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 722 - 722
Опубликована: Май 15, 2025
Glaesserella
parasuis
(G.
parasuis)
causes
vascular
inflammation
in
piglets,
resulting
damage.
However,
the
mechanism
causing
remains
unclear.
Baicalin
possesses
an
anti-inflammatory
function.
Tumor
necrosis
factor-like
weak
inducer
of
apoptosis
(TWEAK)
has
been
implicated
immunosuppression.
CD163,
a
scavenger
receptor
expressed
on
macrophages
that
acts
as
decoy
for
TWEAK,
plays
crucial
role
regulation
autophagy
and
inflammation.
This
research
investigated
efficacy
baicalin
reducing
immunosuppression
elicited
by
G.
through
CD163/TWEAK-mediated
autophagy.
The
data
demonstrated
altered
routine
blood
indicators
biochemical
parameters,
increased
cytokine
production,
induced
vessel
tissue
reduced
CD3+
T
cell
proportion,
CD3+CD4+
CD3+CD8+
proportion
piglet
blood.
proteomic
analysis
revealed
CD163
was
differentially
vessels
challenged
piglets.
found
to
regulate
CD163/TWEAK
axis
expression,
inhibit
Notch/Wnt
signaling
pathway
activation,
promote
autophagy,
reduce
NLRP3/Caspase
1
activation.
also
decreased
production
alleviated
pathological
damage
parasuis-challenged
Taken
together,
this
study
indicates
alleviates
parasuis-induced
might
finding
suggests
could
serve
potential
therapeutic
agent
control
infection
related
Язык: Английский