The Therapeutic Potential of Baicalin and Baicalein in Breast Cancer: A Systematic Review of Mechanisms and Efficacy

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 181 - 181

Опубликована: Март 11, 2025

Cancer remains a leading cause of death globally, with breast cancer being the most commonly diagnosed in women. This systematic review focuses on therapeutic potential baicalin and baicalein, two bioactive flavonoids derived from Scutellaria baicalensis, treatment. These compounds exhibit anticancer properties through mechanisms such as apoptosis induction, cell cycle arrest, inhibition metastasis. Baicalin baicalein modulate key signaling pathways, including NF-κB, PI3K/AKT/mTOR, Wnt/β-catenin, have shown efficacy both vitro vivo models. Their synergy chemotherapy agents incorporation into nanotechnology-based delivery systems highlight opportunities to enhance outcomes. However, current evidence is predominantly preclinical, limited clinical trials validate their safety humans. Challenges poor bioavailability rapid metabolism also underscore need for advanced formulation strategies. synthesizes molecular mechanisms, efficacy, applications research.

Язык: Английский

Exploring the mechanism of baicalein on breast cancer based on network pharmacology, molecular docking and in vivo experiments

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117297 - 117297

Опубликована: Март 1, 2025

Язык: Английский