Interplay of anxiety, depression, vascular function, and biomarkers in post-myocardial infarction patients DOI Creative Commons
Jan Kafol, Borut Jug, Mojca Božič Mijovski

и другие.

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Май 26, 2025

Background and aims Coronary artery disease (CAD) is a leading cause of mortality. Depression anxiety are common in CAD patients negatively affect quality life, physical functioning, adherence to cardiac rehabilitation (CR) programs. This study aimed identify possible associations with clinically relevant parameters, vascular function blood biomarkers. Methods Participants were consecutively recruited during intake visits at the University Medical Centre Ljubljana within 4 months myocardial infarction (MI). Hospital Anxiety Scale (HADS) scores analyzed relation endothelial (assessed flow-mediated dilation), arterial stiffness, biomarkers (fibrinogen, endocan, brain-derived neurotrophic factor [BDNF]) post-MI patients. All biomarker assessments performed 5 days questionnaire completion prior start rehabilitation. Results There 105 included study. The median age was 56 years (49–62), 80.0% participants male. Clinically depression present 29.5% 21.9% participants, respectively. significantly associated younger age, higher body mass index, increased total HADS correlated age. Endothelial showed no significant scores. Vital signs differences, except for slightly systolic pressure those depression. Fibrinogen levels depression, while endocan BDNF lower anxiety. Conclusion especially However, as screening tool not diagnostic instrument, given study’s observational design, findings reflect rather than causality. Routine targeted mental health support CR programs might improve participation, enhance cardiovascular recovery, optimize long-term outcomes. These underscore clinical importance psychological assessment early period integration evaluation into care.

Язык: Английский

Investigating Molecular Mechanisms in Ischemic Preconditioning-Induced Resiliency to Severe Acute Global Cerebral Ischemia Using a Mouse Model of Chronic Cerebral Hypoperfusion DOI Creative Commons
Roli Kushwaha, Shashikant Patel,

Yuvaraj Kotteeswaran

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)

Опубликована: Март 26, 2025

Cerebral ischemic preconditioning offers a promising strategy to enhance resilience severe insults. Unilateral common carotid artery occlusion (UCCAo) is valuable model simulate chronic cerebral hypoperfusion (CCH). This study explored UCCAo-induced CCH as stimulus induce tolerance against transient global ischemia (tGCI) induced by bilateral (BCCAo) in both male and female mice. We evaluated the effects of on neuroprotection recovery through behavioral, histopathological, molecular analyses. Laser Doppler Imaging (LDI) confirmed significant post-UCCAo. Preconditioning reduced mortality rates at days 1 7 post-surgery compared BCCAo, suggesting its neuroprotective potential. Neurodeficit scoring demonstrated protection preconditioned animals with aligning closer sham controls. Behavioral assays revealed improved motor cognitive outcomes groups, sex-specific differences evident dynamics. Molecular analyses indicated reactive astrocyte (GFAP) microglial (IBA1) activation animals, reflecting controlled glial responses. Sex-dependent variations markers hypoxia (Hif1a), autophagy (Becn1), neurogenesis (Sox2) highlighted neuroadaptive cellular influences resilience. enhanced synaptic plasticity upregulating PSD-95, synaptophysin BDNF levels. In addition, increased VEGF expression blood serum vascular remodeling angiogenesis. positions reliable for exploring mechanisms advance therapeutic strategies mitigating stroke.

Язык: Английский

Процитировано

1
Clinical observational studies of potential participants’ current negative affect status for a clinical study of stem cell therapy for ischemic stroke: study protocol DOI Creative Commons
Xixian Qin, Mengyao Li, Xin Sun

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

The number of clinical research projects on stem cell therapy for stroke has increased annually with the rapid development cells and regenerative medicine technologies. Some evidence indicates that negative emotions can affect recruitment, compliance, retention, satisfaction, even treatment outcomes participants in research. However, knowledge is insufficient regarding patients' associated their participation potential studies. Therefore, study aims to investigate main influencing factors stroke. This protocol follows Strengthening Reporting Observational Studies Epidemiology Good Practice Studies. questionnaire this will include 59 questions (1) demographic characteristics, (2) levels anxiety, depression, social support, general self-efficacy, self-perceived burden. study's strength it contribute key predictors affectivity undergoing trials results support center researchers intervening participants' emotions, which important managers policymakers worldwide. developed was validated through a rigorous process, demonstrating scientific validity evaluation instrument provides clinicians standardized assessment monitor treatment-emergent emotional distress during experimental interventions, showing particular promise identifying early psychological risks novel biological therapies.

Язык: Английский

Процитировано

1
Interplay of anxiety, depression, vascular function, and biomarkers in post-myocardial infarction patients DOI Creative Commons
Jan Kafol, Borut Jug, Mojca Božič Mijovski

и другие.

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Май 26, 2025

Background and aims Coronary artery disease (CAD) is a leading cause of mortality. Depression anxiety are common in CAD patients negatively affect quality life, physical functioning, adherence to cardiac rehabilitation (CR) programs. This study aimed identify possible associations with clinically relevant parameters, vascular function blood biomarkers. Methods Participants were consecutively recruited during intake visits at the University Medical Centre Ljubljana within 4 months myocardial infarction (MI). Hospital Anxiety Scale (HADS) scores analyzed relation endothelial (assessed flow-mediated dilation), arterial stiffness, biomarkers (fibrinogen, endocan, brain-derived neurotrophic factor [BDNF]) post-MI patients. All biomarker assessments performed 5 days questionnaire completion prior start rehabilitation. Results There 105 included study. The median age was 56 years (49–62), 80.0% participants male. Clinically depression present 29.5% 21.9% participants, respectively. significantly associated younger age, higher body mass index, increased total HADS correlated age. Endothelial showed no significant scores. Vital signs differences, except for slightly systolic pressure those depression. Fibrinogen levels depression, while endocan BDNF lower anxiety. Conclusion especially However, as screening tool not diagnostic instrument, given study’s observational design, findings reflect rather than causality. Routine targeted mental health support CR programs might improve participation, enhance cardiovascular recovery, optimize long-term outcomes. These underscore clinical importance psychological assessment early period integration evaluation into care.

Язык: Английский

Процитировано

0