Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(2)

Опубликована: Янв. 27, 2025

ABSTRACT Lycopene (LYC) is an extremely powerful antioxidant with the potential to treat a range of diseases and inhibit ferroptosis. This research aims elucidate how LYC impacts polycystic ovarian syndrome (PCOS) action mechanisms. A PCOS rat model was constructed by injecting DHEA. Different doses were injected intraperitoneally in rats, estrous cycle recorded. The histopathological damage ovary rats observed HE staining, testosterone (T), estradiol (E2), luteinizing hormone (LH) follicle stimulating (FSH) levels examined ELISA kits. Transmission electron microscopy, prussian blue biochemical kits determine Immunohistochemistry Western blot assess ferroptosis‐related AMPK/Nrf2 pathway‐related proteins explore whether affects ferroptosis through this pathway. had significantly higher body weights, weights indices, disorganized cycles, which dose‐dependently ameliorated LYC. In addition, restored normal secretion T, E2, LH, FSH. attenuates iron deposition tissues, reduces ROS levels, inhibits Notably, activated pathway, AMPK inhibitor intervention attenuated therapeutic effect suggesting that acts disruption, ameliorates pathological impairments, modulating

Язык: Английский

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Tangshenning Formula Alleviates Tubular Injury in Diabetic Kidney Disease via the Sestrin2/AMPK/PGC-1α Axis: Restoration of Mitochondrial Function and Inhibition of Ferroptosis

Journal of Ethnopharmacology, Год журнала: 2025, Номер 345, С. 119579 - 119579

Опубликована: Март 3, 2025

Язык: Английский

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Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis

Journal of Asian Natural Products Research, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Апрель 2, 2025

Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) common sepsis-induced inflammatory response. Using transcriptomics combined metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis an important mechanism for salidroside to improve AKI (SI-AKI).

Язык: Английский

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NRF2-mediated osteoblast anti-ferroptosis effect promotes induced membrane osteogenesis

Bone, Год журнала: 2024, Номер unknown, С. 117384 - 117384

Опубликована: Дек. 1, 2024

Язык: Английский

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