Smaller-Sized Silica Nanoparticles Exacerbated Cardiomyocyte Pyroptosis by Impairing Mitophagy to Activate mtDNA-cGAS-STING Signaling DOI
Dong‐Xu Han, Tong Xu,

Xuan Lyu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Silica nanoparticles (SiNPs) are a nanometer powder widely used in various consumer products, engineering, the food industry, and medical applications. Environmental SiNPs have attracted attention owing to their exposure cardiovascular adverse events. Here, we exposed C57/BL6 mouse HL-1 cells with different-sized (50, 300 nm, 1 μm) investigate underlying mechanism of its toxicity. Mice three-sized showed significant weight loss after 21 days treatment. Heart tibia length ratio histopathology staining indicated increased heart volume cross-sectional area myocardial fibers mice SiNPs. In vivo vitro experiments results that causes size-dependent mitochondrial damage initiates mitophagy. Notably, compared caused by nm μm exposure, 50 blocked autophagy flux, leading excessive accumulation DNA (mtDNA) cytoplasm, ultimately exacerbating downstream cGAS-STING pathway-mediated pyroptosis. This study revealed potential health risks helped understand differences cytotoxicity different sizes.

Язык: Английский

Smaller-Sized Silica Nanoparticles Exacerbated Cardiomyocyte Pyroptosis by Impairing Mitophagy to Activate mtDNA-cGAS-STING Signaling DOI
Dong‐Xu Han, Tong Xu,

Xuan Lyu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Silica nanoparticles (SiNPs) are a nanometer powder widely used in various consumer products, engineering, the food industry, and medical applications. Environmental SiNPs have attracted attention owing to their exposure cardiovascular adverse events. Here, we exposed C57/BL6 mouse HL-1 cells with different-sized (50, 300 nm, 1 μm) investigate underlying mechanism of its toxicity. Mice three-sized showed significant weight loss after 21 days treatment. Heart tibia length ratio histopathology staining indicated increased heart volume cross-sectional area myocardial fibers mice SiNPs. In vivo vitro experiments results that causes size-dependent mitochondrial damage initiates mitophagy. Notably, compared caused by nm μm exposure, 50 blocked autophagy flux, leading excessive accumulation DNA (mtDNA) cytoplasm, ultimately exacerbating downstream cGAS-STING pathway-mediated pyroptosis. This study revealed potential health risks helped understand differences cytotoxicity different sizes.

Язык: Английский

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