New insights into the interplay between MALAT1 and miRNA-155 to unravel potential diagnostic and prognostic biomarkers of Behçet’s disease

Clinical Rheumatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Abstract The current study was deployed to evaluate the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miR-155, along with inflammatory markers, TNFα IL-6, adhesion molecule, cluster differentiation 106 (CD106), in Behçet’s disease (BD) pathogenesis. also assessed MALAT1/miR-155 as promising diagnostic prognostic biomarkers for BD. retrospective case–control included 74 Egyptian BD patients 50 age sex-matched controls. Blood samples were collected, then, serum separated further biochemical molecular investigations. gene expression MALAT1 miR-155 measured using qRT-PCR, whereas levels TNFα, CD106 estimated ELISA technique. significantly downregulated, upregulated among patients, compared control subjects. Levels elevated patients. Further downregulation together upregulation observed active relative inactive group. Receiver-operating-characteristic analysis revealed that could discriminate from controls, on one hand, other hand. negatively correlated CD106, while positively them. Logistic regression analyses demonstrated a significant independent predictor susceptibility, an negative activity. For first time, research enlightens pathogenesis via impacting IL-6/TNF-α/CD-106 signaling. As well, be regarded novel non-invasive may improve diagnosis prognosis. Key Points •MALAT1/miR-155 exerts potential disease. are targets

Язык: Английский

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Role of long non-coding RNAs and natural products in prostate cancer: insights into key signaling pathways

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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Interplay of Endoplasmic Reticulum Stress, Inflammation, Apoptosis, and Oxidative Stress in Corticosteroid-Induced Anxiety and Depression: Exploring Therapeutic Potential of Hydrogen Sulfide and Sertraline

ACS Chemical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Prolonged exposure to corticosteroids (CORTs) triggers depression and anxiety symptoms either endogenously or exogenously via stimulating endoplasmic reticulum stress (ERS). The study assessed the therapeutic implications of hydrogen sulfide (H2S) versus sertraline (SERT) in alleviating induced by CORTs through modulation ERS its inflammatory, oxidative, apoptotic consequences. Rats were subdivided into four groups: control, CORT (20 mg/kg), NaHS (100 μmol/kg), SERT (10 mg/kg) for 21 days. Behavioral histological examinations cerebral cortex performed. levels CHOP, GADD34, EIF2AK3, GRP78, caspase 3, miR-146a analyzed using qRT-PCR. CORTs, serotonin, BDNF, TNF-α, BCL2, NRF2, ATF4 measured ELISA, whereas those IL-1β BAX immunohistochemical techniques. Total phosphorylated PERK western blotting, GSH MDA a colorimetric assay. In present study, upregulated gene expression Caspase it downregulated that miR-146a. GSH, NRF2 decreased, ATF4, IL-1β, BAX, elevated. On contrary, reversed all above-mentioned changes. H2S shows promise counteracting targeting cascades, mitigating inflammation, oxidative insults, apoptosis cortex. elicits neuroprotective effects miR-146a-3p/GRP78/CHOP/PERK/ATF4/GADD34 signaling pathway regulating markers BAX/BCL2 inflammatory TNF-α and/IL-1β. Compared with SERT, exhibited superior anxiolytic antidepressive effects.

Язык: Английский

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Alternative medicines in oncology: a focus on natural products against gastric cancer

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

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