Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review

Antioxidants, Год журнала: 2025, Номер 14(1), С. 81 - 81

Опубликована: Янв. 12, 2025

This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for antimicrobial, anti-inflammatory, antioxidant properties. Recent research emphasizes positive role in osteogenesis, primarily through modulation osteoclast osteoblast activity via molecular pathways. Key mechanisms include reducing inflammatory cytokines, protecting against oxidative stress, upregulating growth factor essential formation. While such as Caffeic Acid Phenethyl Ester, Apigenin, Quercetin, Ferulic have been well-documented, emerging evidence points to significant roles less-studied like Pinocembrin, Kaempferol, p-Coumaric acid, Galangin. synthesizes current literature, focusing which these influence osteogenesis. Firstly, it techniques characterizing presented propolis, chemogeographic variations composition, both crude extracts isolated tissue, offering comprehensive analysis recent findings across different experimental models. Further, discusses In summary, modulate signaling pathways, including nuclear kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial factor, reactive oxygen species. These pathways receptor activator kappa-β/receptor kappa-β ligand/osteoprotegerin system, fostering cell differentiation. regulation mitigates excessive formation, stimulates activity, ultimately contributes restoration homeostasis maintaining balanced remodeling process.

Язык: Английский

Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177501 - 177501

Опубликована: Март 1, 2025

Язык: Английский