Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review DOI Open Access

Krzysztof Gofron,

Andrzej Wasilewski, Sylwia Małgorzewicz

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1303 - 1303

Опубликована: Апрель 9, 2025

Background: GLP-1 analogues are a relatively new class of medications that form the cornerstone diabetes treatment. They possess invaluable glucose-lowering properties without hypoglycemic effects as well strong cardioprotective effects. The gut microbiome has become focus numerous studies, demonstrating its influence not only on but also overall well-being entire body. However, analogs microbiota remain uncertain. Scope review: Our systematic review (based PRISMA guidelines) aimed to gather knowledge analogue composition, richness, and abundance in both animal human models. Conclusions: Thirty-eight studies were included this review. have demonstrated notable impact diversity microbiota. We can conclude, following obtained research results our study, liraglutide promotes growth beneficial genera relevant for metabolic functions. Exenatide exendin-4 administration showed various composition studies. In models, it increased associated with improved metabolism; however, linked better functions escalated inflammation increased. Following dulaglutide administration, increases Bacteroides, Akkermansia, Ruminococcus, connected an model, significant. Finally, varied after semaglutide treatment, which A. muciniphila, known positive functions, increased; microbial decreased. Semaglutide treatment provided indicating many confounding factors semaglutide’s Results due dissimilarities studied populations duration Further is essential confirm these findings recognize their implications clinical outcomes patients.

Язык: Английский

Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review DOI Open Access

Krzysztof Gofron,

Andrzej Wasilewski, Sylwia Małgorzewicz

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1303 - 1303

Опубликована: Апрель 9, 2025

Background: GLP-1 analogues are a relatively new class of medications that form the cornerstone diabetes treatment. They possess invaluable glucose-lowering properties without hypoglycemic effects as well strong cardioprotective effects. The gut microbiome has become focus numerous studies, demonstrating its influence not only on but also overall well-being entire body. However, analogs microbiota remain uncertain. Scope review: Our systematic review (based PRISMA guidelines) aimed to gather knowledge analogue composition, richness, and abundance in both animal human models. Conclusions: Thirty-eight studies were included this review. have demonstrated notable impact diversity microbiota. We can conclude, following obtained research results our study, liraglutide promotes growth beneficial genera relevant for metabolic functions. Exenatide exendin-4 administration showed various composition studies. In models, it increased associated with improved metabolism; however, linked better functions escalated inflammation increased. Following dulaglutide administration, increases Bacteroides, Akkermansia, Ruminococcus, connected an model, significant. Finally, varied after semaglutide treatment, which A. muciniphila, known positive functions, increased; microbial decreased. Semaglutide treatment provided indicating many confounding factors semaglutide’s Results due dissimilarities studied populations duration Further is essential confirm these findings recognize their implications clinical outcomes patients.

Язык: Английский

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