Structural Characterization of Polysaccharides from Noni (Morinda citrifolia L.) Juice and Their Preventive Effect on Oxidative Stress Activity
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1103 - 1103
Опубликована: Фев. 27, 2025
Polysaccharides
are
very
promising
molecules
in
the
field
of
pharmacotherapy.
Knowing
this,
aim
this
study
was
to
extract,
characterize,
and
evaluate
action
polysaccharides
noni
juice,
using
biological
models
Type
2
diabetes
mellitus
processes.
In
study,
one
polysaccharide
named
NJSPd-1
separated
from
fermented
fruit
juice.
The
characterization
assay
showed
that
had
a
molecular
weight
(Mw)
18,545
Da.
consisted
galacturonic
acid,
galactose,
rhamnose,
arabinose,
with
molar
ratio
28.79:20.34:19.80:18.84
according
HPGPC
analysis,
glycosidic
bond
mainly
included
→4)-α-D-GalAp-(1→,
4)-β-D-Glcp-(1→,
→2)-α-L-Rhap-(1→,
→3)-α-L-Araf-(1→.
prevention
oxidative
stress
activities
by
evaluated
high-glucose-induced
HepG2
cells.
vitro
results
influenced
downregulation
proteins
genes
Nrf2,
Keap1,
HO-1,
NQO1
These
suggest
exerted
protective
effect
against
cells
activating
Nrf2/HO-1/NQO1
signaling
pathway.
Язык: Английский
Rutin resists Aspergillus fumigatus keratitis by activating Nrf2/HO-1 pathway, inhibiting Dectin-1/p-Syk pathway and affecting fungal structures
Experimental Eye Research,
Год журнала:
2025,
Номер
unknown, С. 110323 - 110323
Опубликована: Март 1, 2025
Язык: Английский
The therapeutic effect and mechanism of carnosic acid in Aspergillus fumigatus keratitis
Experimental Eye Research,
Год журнала:
2025,
Номер
254, С. 110338 - 110338
Опубликована: Март 14, 2025
Язык: Английский
The effect and mechanism of enhanced photocatalytic fungicidal activity on nitrogen doped carbon dots-modified titanium dioxide
Carbon,
Год журнала:
2025,
Номер
unknown, С. 120314 - 120314
Опубликована: Апрель 1, 2025
Язык: Английский
Zeolitic Imidazolate Framework-90 Treats Fungal Keratitis by Promoting Macrophage Apoptosis and Targeting Increased Mitochondrial Reactive Oxygen Species in Aspergillus Fumigatus
Xueyun Fu,
Lina Zhang,
Jing Lin
и другие.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 4551 - 4569
Опубликована: Апрель 1, 2025
Fungal
keratitis
is
a
severe
vision-threatening
corneal
infection
with
prognosis
influenced
by
fungal
virulence
and
the
host's
immune
defense
mechanisms.
However,
there
still
lack
of
effective
drugs
that
attenuate
while
relieving
inflammatory
response
caused
keratitis.
Finding
an
treatment
to
solve
these
problems
particularly
important.
We
synthesized
Zeolitic
imidazolate
framework-90
(ZIF-90)
water-based
synthesis
method
characterized
it.
In
vitro
experiments
included
mycelium
electron
microscopy,
Cell
Counting
Kit-8
(CCK-8),
Enzyme-linked
immunosorbent
assay
(ELISA).
These
trials
verified
disruptive
effects
ZIF-90
on
morphology,
cell
membrane,
wall,
biofilm
formation
Aspergillus
fumigatus
(A.
fumigatus).
also
demonstrated
impact
proinflammatory
cytokines
tumor
necrosis
factor-α
(TNF-α)
interleukin-6
(IL-6).
Moreover,
effect
mitochondrial
reactive
oxygen
species
(mtROS)
cells
fungi
was
MitoSOX
Red
Mitochondrial
Superoxide
Indicator
(MitoSOX).
vivo,
toxicity
test,
establishment
mycotic
mouse
model,
immunofluorescence
staining
were
used
evaluate
efficacy
in
procedure
addition,
investigate
whether
metal-ligand
zinc
organic
ligand
imidazole
acted
as
essential
factors
ZIF-90,
we
investigated
antimicrobial
anti-inflammatory
ZIF-8,
ZIF-67
Metal-Organic
Frameworks-74
(Zn)
(MOF-74
(Zn))
Minimum
Inhibitory
Concentration
(MIC)
ELISA
experiments.
has
therapeutic
keratitis,
which
could
break
protective
organelles
A.
fumigatus,
such
wall.
can
be
targeted
increase
amount
mtROS
promote
apoptosis
macrophages.
The
results
both
ions
possessed
effects.
exhibited
better
antifungal
properties
than
ZIF-67,
MOF-74
(Zn).
Язык: Английский