Deleted Journal,
Год журнала:
2024,
Номер
1(2), С. 134 - 149
Опубликована: Дек. 1, 2024
Niclosamide,
an
FDA-approved
anti-parasitic
drug,
has
demonstrated
significant
potential
as
a
repurposed
anti-cancer
agent
due
to
its
ability
interfere
with
multiple
oncogenic
pathways.
However,
clinical
application
been
hindered
by
poor
solubility
and
bioavailability.
Lipid-based
nanocarrier
systems
such
liposomes,
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers
(NLCs),
nanoemulsions
(LNE),
along
prodrugs,
have
successfully
employed
researchers
overcome
these
limitations
improve
niclosamide’s
pharmacokinetic
profile.
Lipids
are
the
core
organic
compounds
which
serve
foundation
of
advanced
drug
delivery
methods
in
turn
play
critical
role
enhancing
therapeutic
efficacy
through
improving
encapsulate
niclosamide,
protect
it
from
degradation,
facilitate
release,
may
targeted
future.
While
niclosamide
holds
anticancer
multi-pathway
inhibitory
effects,
challenges
associated
bioavailability
rapid
clearance
underscore
need
for
innovative
chemical
modifications
unlock
full
potential.
This
review
aims
present
latest
instances
lipid-based
compile
successful
strategies
be
when
aiming
develop
effective
therapies.
Journal of the American Oil Chemists Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
DHA
has
unique
functional
properties
in
human
health.
Various
recommendations
to
increase
dietary
intake
have
been
proposed.
However,
there
is
a
difference
between
and
nutritional
functions.
Therefore,
bioavailability
crucial
for
the
efficacy
of
intake.
A
proper
delivery
system
can
up
50%–150%.
phospholipid
triglyceride
forms
readily
absorbed
by
body
more
than
ethyl
ester
form.
oil
encapsulation
attain
better
bioavailability,
controlled
release,
masking
taste
odor,
besides
improving
oxidative
stability.
The
formation
matrix
which
hidden
inside
wall
materials.
Wall
materials
such
as
whey
protein
concentrates
are
often
preferred,
multiple
layers
through
molecular
assembly
pursued.
In
Forming
right
matrix,
emulsification
technologies
applied
designed
where
nanoemulsion
or
liposome‐type
structures
advantages.
For
an
encapsulated
powder
product,
spray
drying
developed
alternative
techniques
give
large
space
improvement,
novel
developments
spray–freeze
may
offer
various
This
review
will
bring
practical
picture
subject
including
overall
evaluation
patent
applications
well
summary/remarks
future
developments.
Deleted Journal,
Год журнала:
2024,
Номер
1(2), С. 134 - 149
Опубликована: Дек. 1, 2024
Niclosamide,
an
FDA-approved
anti-parasitic
drug,
has
demonstrated
significant
potential
as
a
repurposed
anti-cancer
agent
due
to
its
ability
interfere
with
multiple
oncogenic
pathways.
However,
clinical
application
been
hindered
by
poor
solubility
and
bioavailability.
Lipid-based
nanocarrier
systems
such
liposomes,
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers
(NLCs),
nanoemulsions
(LNE),
along
prodrugs,
have
successfully
employed
researchers
overcome
these
limitations
improve
niclosamide’s
pharmacokinetic
profile.
Lipids
are
the
core
organic
compounds
which
serve
foundation
of
advanced
drug
delivery
methods
in
turn
play
critical
role
enhancing
therapeutic
efficacy
through
improving
encapsulate
niclosamide,
protect
it
from
degradation,
facilitate
release,
may
targeted
future.
While
niclosamide
holds
anticancer
multi-pathway
inhibitory
effects,
challenges
associated
bioavailability
rapid
clearance
underscore
need
for
innovative
chemical
modifications
unlock
full
potential.
This
review
aims
present
latest
instances
lipid-based
compile
successful
strategies
be
when
aiming
develop
effective
therapies.
