Planetary sleep medicine: Studying sleep at the individual, population, and planetary level

Frontiers in Public Health, Год журнала: 2022, Номер 10

Опубликована: Окт. 18, 2022

Circadian rhythms are a series of endogenous autonomous oscillators that generated by the molecular circadian clock which coordinates and synchronizes internal time with external environment in 24-h daily cycle (that can also be shorter or longer than 24 h). Besides rhythms, there exist as well other biological have different scales, including seasonal annual rhythms. deeply permeate human life, at any level, spanning from molecular, subcellular, cellular, tissue, organismal level to environmental exposures, behavioral lifestyles. Humans immersed what has been called “circadian landscape,“ being highly pervasive ubiquitous, affecting every ecosystem on planet, plants insects, fishes, birds, mammals, animals. Anthropogenic behaviors producing cascading compounding effects, detrimental impacts health. However, effects climate change sleep relatively overlooked. In present narrative review paper, we wanted offer way re-read/re-think medicine planetary health perspective. Climate change, through complex either direct indirect mechanisms, (i) pollution- poor air quality-induced oxygen saturation variability/hypoxia, (ii) changes light conditions increases nighttime, (iii) fluctuating temperatures, warmer values, heat due extreme weather, (iv) psychological distress imposed disasters (like floods, wildfires, droughts, hurricanes, infectious outbreaks emerging reemerging pathogens) may contribute inducing mismatches between environment, disrupting sleep, causing quantity quality disorders, such insomnia, sleep-related breathing issues, among others. will generate relevant costs impact more vulnerable populations underserved areas, thus widening already existing global geographic, age-, sex-, gender-related inequalities.

Язык: Английский

---

Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies

Molecular Aspects of Medicine, Год журнала: 2021, Номер 80, С. 100984 - 100984

Опубликована: Июнь 20, 2021

Язык: Английский

---

Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural–glial coupling in Drosophila

National Science Review, Год журнала: 2022, Номер 9(12)

Опубликована: Июль 27, 2022

Abstract While endogenous lipids are known to exhibit rhythmic oscillations, less is about how specific modulate circadian behavior. Through a series of loss-of-function and gain-of-function experiments on ceramide phosphoethanolamine (CPE) synthase Drosophila, we demonstrated that pan-glial-specific deficiency in membrane CPE, the structural analog mammalian sphingomyelin (SM), leads arrhythmic locomotor behavior shortens lifespan, while reverse true for increasing CPE. Comparative proteomics uncovered dysregulated synaptic glutamate utilization transport CPE-deficient flies. An extensive genetic screen was conducted verify role differentially expressed proteins regulation. Arrhythmic locomotion under cpes1 mutant background rescued only by restoring CPE or SM through expressing their respective synthases. Our results underscore essential maintaining homeostasis modulating Drosophila. The findings suggest region-specific elevations functional can benefit

Язык: Английский

---

Feeding Behavior Modifies the Circadian Variation in RR and QT intervals by Distinct Mechanisms in Mice

AJP Regulatory Integrative and Comparative Physiology, Год журнала: 2024, Номер 327(1), С. R109 - R121

Опубликована: Май 20, 2024

Rhythmic feeding behavior is critical for regulating phase and amplitude in the ≈24-h variation of heart rate (RR intervals), ventricular repolarization (QT core body temperature mice. We hypothesized changes cardiac electrophysiology associated with were secondary to temperature. Telemetry was used record electrocardiograms mice during ad libitum-fed conditions after inverting normal by restricting food access light cycle. Light cycle-restricted modified 24-h rhythms RR QT intervals, realign new time. Changes alone could not account intervals. Heart variability analysis inhibiting β-adrenergic muscarinic receptors suggested that intervals autonomic signaling. In contrast, closely mirrored Studies at thermoneutrality confirmed daily interval, but primarily reflected (even conditions). Correcting interval differences helped unmask prolongation starting a mouse model long syndrome. conclude alters signaling regulate respectively.

Язык: Английский

---

Novel insights into the circadian modulation of lipid metabolism in chicken livers revealed by RNA sequencing and weighted gene co-expression network analysis

Poultry Science, Год журнала: 2024, Номер 103(12), С. 104321 - 104321

Опубликована: Сен. 17, 2024

Язык: Английский

---