AJP Regulatory Integrative and Comparative Physiology,
Год журнала:
2024,
Номер
327(1), С. R109 - R121
Опубликована: Май 20, 2024
Rhythmic
feeding
behavior
is
critical
for
regulating
phase
and
amplitude
in
the
≈24-h
variation
of
heart
rate
(RR
intervals),
ventricular
repolarization
(QT
core
body
temperature
mice.
We
hypothesized
changes
cardiac
electrophysiology
associated
with
were
secondary
to
temperature.
Telemetry
was
used
record
electrocardiograms
mice
during
ad
libitum-fed
conditions
after
inverting
normal
by
restricting
food
access
light
cycle.
Light
cycle-restricted
modified
24-h
rhythms
RR
QT
intervals,
realign
new
time.
Changes
alone
could
not
account
intervals.
Heart
variability
analysis
inhibiting
β-adrenergic
muscarinic
receptors
suggested
that
intervals
autonomic
signaling.
In
contrast,
closely
mirrored
Studies
at
thermoneutrality
confirmed
daily
interval,
but
primarily
reflected
(even
conditions).
Correcting
interval
differences
helped
unmask
prolongation
starting
a
mouse
model
long
syndrome.
conclude
alters
signaling
regulate
respectively.
Frontiers in Public Health,
Год журнала:
2022,
Номер
10
Опубликована: Окт. 18, 2022
Circadian
rhythms
are
a
series
of
endogenous
autonomous
oscillators
that
generated
by
the
molecular
circadian
clock
which
coordinates
and
synchronizes
internal
time
with
external
environment
in
24-h
daily
cycle
(that
can
also
be
shorter
or
longer
than
24
h).
Besides
rhythms,
there
exist
as
well
other
biological
have
different
scales,
including
seasonal
annual
rhythms.
deeply
permeate
human
life,
at
any
level,
spanning
from
molecular,
subcellular,
cellular,
tissue,
organismal
level
to
environmental
exposures,
behavioral
lifestyles.
Humans
immersed
what
has
been
called
“circadian
landscape,“
being
highly
pervasive
ubiquitous,
affecting
every
ecosystem
on
planet,
plants
insects,
fishes,
birds,
mammals,
animals.
Anthropogenic
behaviors
producing
cascading
compounding
effects,
detrimental
impacts
health.
However,
effects
climate
change
sleep
relatively
overlooked.
In
present
narrative
review
paper,
we
wanted
offer
way
re-read/re-think
medicine
planetary
health
perspective.
Climate
change,
through
complex
either
direct
indirect
mechanisms,
(i)
pollution-
poor
air
quality-induced
oxygen
saturation
variability/hypoxia,
(ii)
changes
light
conditions
increases
nighttime,
(iii)
fluctuating
temperatures,
warmer
values,
heat
due
extreme
weather,
(iv)
psychological
distress
imposed
disasters
(like
floods,
wildfires,
droughts,
hurricanes,
infectious
outbreaks
emerging
reemerging
pathogens)
may
contribute
inducing
mismatches
between
environment,
disrupting
sleep,
causing
quantity
quality
disorders,
such
insomnia,
sleep-related
breathing
issues,
among
others.
will
generate
relevant
costs
impact
more
vulnerable
populations
underserved
areas,
thus
widening
already
existing
global
geographic,
age-,
sex-,
gender-related
inequalities.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Июнь 20, 2024
Abstract
Tissue
specificity
is
a
fundamental
property
of
an
organ
that
affects
numerous
biological
processes,
including
aging
and
longevity,
regulated
by
the
circadian
clock.
However,
distinction
between
circadian-affected
tissue
other
specificities
remains
poorly
understood.
Here,
using
multi-omics
data
on
rhythms
in
mice,
we
discovered
approximately
35%
tissue-specific
genes
are
directly
affected
regulation.
These
have
higher
expression
levels
associated
with
metabolism
hepatocytes.
They
also
exhibit
specific
features
long-reads
sequencing
data.
Notably,
these
longevity
at
both
gene
level
network
module
level.
The
oscillates
response
to
caloric
restricted
feeding
regimens,
which
been
demonstrated
promote
longevity.
In
addition,
disrupted
various
disorders.
Our
study
indicates
modulation
essential
for
understanding
mechanisms
regulate
genomic
National Science Review,
Год журнала:
2022,
Номер
9(12)
Опубликована: Июль 27, 2022
Abstract
While
endogenous
lipids
are
known
to
exhibit
rhythmic
oscillations,
less
is
about
how
specific
modulate
circadian
behavior.
Through
a
series
of
loss-of-function
and
gain-of-function
experiments
on
ceramide
phosphoethanolamine
(CPE)
synthase
Drosophila,
we
demonstrated
that
pan-glial-specific
deficiency
in
membrane
CPE,
the
structural
analog
mammalian
sphingomyelin
(SM),
leads
arrhythmic
locomotor
behavior
shortens
lifespan,
while
reverse
true
for
increasing
CPE.
Comparative
proteomics
uncovered
dysregulated
synaptic
glutamate
utilization
transport
CPE-deficient
flies.
An
extensive
genetic
screen
was
conducted
verify
role
differentially
expressed
proteins
regulation.
Arrhythmic
locomotion
under
cpes1
mutant
background
rescued
only
by
restoring
CPE
or
SM
through
expressing
their
respective
synthases.
Our
results
underscore
essential
maintaining
homeostasis
modulating
Drosophila.
The
findings
suggest
region-specific
elevations
functional
can
benefit
AJP Regulatory Integrative and Comparative Physiology,
Год журнала:
2024,
Номер
327(1), С. R109 - R121
Опубликована: Май 20, 2024
Rhythmic
feeding
behavior
is
critical
for
regulating
phase
and
amplitude
in
the
≈24-h
variation
of
heart
rate
(RR
intervals),
ventricular
repolarization
(QT
core
body
temperature
mice.
We
hypothesized
changes
cardiac
electrophysiology
associated
with
were
secondary
to
temperature.
Telemetry
was
used
record
electrocardiograms
mice
during
ad
libitum-fed
conditions
after
inverting
normal
by
restricting
food
access
light
cycle.
Light
cycle-restricted
modified
24-h
rhythms
RR
QT
intervals,
realign
new
time.
Changes
alone
could
not
account
intervals.
Heart
variability
analysis
inhibiting
β-adrenergic
muscarinic
receptors
suggested
that
intervals
autonomic
signaling.
In
contrast,
closely
mirrored
Studies
at
thermoneutrality
confirmed
daily
interval,
but
primarily
reflected
(even
conditions).
Correcting
interval
differences
helped
unmask
prolongation
starting
a
mouse
model
long
syndrome.
conclude
alters
signaling
regulate
respectively.
