Thoughts and thinkers: On the complementarity between objects and processes

Physics of Life Reviews, Год журнала: 2025, Номер 52, С. 256 - 273

Опубликована: Янв. 18, 2025

Язык: Английский

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The nonlinearity of regulation in biological networks

npj Systems Biology and Applications, Год журнала: 2023, Номер 9(1)

Опубликована: Апрель 4, 2023

The extent to which the components of a biological system are (non)linearly regulated determines how amenable they therapy and control. To better understand this property termed "regulatory nonlinearity", we analyzed suite 137 published Boolean network models, containing variety complex nonlinear regulatory interactions, using probabilistic generalization logic that George Boole himself had proposed. Leveraging continuous-nature formulation, used Taylor decomposition approximate models with various levels nonlinearity. A comparison resulting series approximations appropriate random ensembles revealed regulation tends be less than expected, meaning higher-order interactions among inputs tend pronounced. further categorical analysis nonlinearity cancer disease networks could not only sometimes higher expected but also relatively more variable. We show variation is caused by differences in apportioning information orders Our results suggest there may have been weak discernible selection pressure for systems evolve linear on average, certain such as cancer, other hand, simultaneously rules.

Язык: Английский

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Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives

Materials & Design, Год журнала: 2024, Номер 243, С. 113072 - 113072

Опубликована: Июнь 6, 2024

Musculoskeletal disorders, as one of the prevalent categories ailments, exert significant impacts on individuals' lives, occupations, and physical activities. Degenerative changes, injuries, infections, tumor resections causing defects in musculoskeletal tissues such cartilage, bones, skeletal muscles, menisci, ligaments, rotator cuffs can detrimentally affect patients' quality life mental well-being. Traditional autologous allogeneic transplantations have been clinically employed. However, transplantation suffers from limitation a finite number transplantable tissues, while faces challenges immune rejection. The extracellular matrix (ECM) serves natural scaffold for cells to fulfill physiological functions adhesion, proliferation, differentiation. Decellularized (dECM) emerges promising biomaterial generated through specific tissue or organ decellularization. Leveraging 3D bioprinting technology, dECM-based biomaterials enable customized printing construction. This study reviews various decellularization techniques, post-decellularization strategies, commonly used technologies. It summarizes integration with technology applied system research. These investigations showcase exciting potential system, offering prospects clinical translation orthopedics.

Язык: Английский

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Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate

Cancers, Год журнала: 2021, Номер 13(21), С. 5300 - 5300

Опубликована: Окт. 22, 2021

Electric potential distributions can act as instructive pre-patterns for development, regeneration, and tumorigenesis in cell systems. The biophysical states influence transcription, proliferation, shape, migration, differentiation through biochemical biomechanical downstream transduction processes. A major knowledge gap is the origin of spatial patterns vivo, their relationship to ion channels electrical synapses known junctions. Understanding this critical basic evolutionary developmental biology well regenerative medicine. We computationally show that cells may express connexin proteins with different voltage-gated junction conductances a way maintain multicellular regions at distinct membrane potentials. increasing connectivity via enhanced function does not always contribute bioelectrical normalization abnormally depolarized patches. From purely view, result suggests reduction rather than increase specific levels also be suitable approach some cases time stages. offer minimum model incorporates effective ultimately related channel are amenable external regulation. suggest encoded information externally modulated by acting on mean fields systems, complementary molecular characteristics individual cells. believe despite limitations biophysically focused model, our useful qualitative insights into collective dynamics system bioelectricity.

Язык: Английский

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Behaviorist approaches to investigating memory and learning: A primer for synthetic biology and bioengineering

Communicative & Integrative Biology, Год журнала: 2021, Номер 14(1), С. 230 - 247

Опубликована: Янв. 1, 2021

The fields of developmental biology, biomedicine, and artificial life are being revolutionized by advances in synthetic morphology. next phase biology bioengineering is resulting the construction novel organisms (biobots), which exhibit not only morphogenesis physiology but functional behavior. It now essential to begin characterize behavioral capacity living constructs terms their ability make decisions, form memories, learn from experience, anticipate future stimuli. These highly diverse, often do resemble familiar model systems used science. Thus, they represent an important context unify standardize vocabulary techniques across ecology, neuroscience. To facilitate study behavior systems, we present a primer on behaviorist tradition that can be probe functions any organism – natural, chimeric, or regardless details origin. provide rich toolkit for advancing bioengineering, evolutionary basal cognition, exobiology, robotics.

Язык: Английский

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Generalizing frameworks for sentience beyond natural species

Animal Sentience, Год журнала: 2022, Номер 7(32)

Опубликована: Янв. 1, 2022

Crump et al. (2022) offer a well-argued example of an essential development: rigorous framework for assessing sentience from the perspective moral concern over agent's welfare. Current and forthcoming developments in bioengineering, synthetic morphology, artificial intelligence, biorobotics, exobiology necessitate expansion generalization this effort. Verbal reports (the Turing Test) homology to human brains are utterly inadequate criteria status novel, unconventional agents that no familiar touchstone phylogeny or anatomy. We must develop principled approaches evaluating (and thus, our responsibility to) beings unfamiliar provenance composition.

Язык: Английский

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Competency in Navigating Arbitrary Spaces: Intelligence as an Invariant for Analyzing Cognition in Diverse Embodiments

Опубликована: Апрель 24, 2022

One of the most salient features life is its capacity to handle novelty: thrive and adapt new circumstances changes both environment internal components. An understanding this central several fields: evolution form function, design effective strategies for biomedicine, creation novel forms via chimeric bioengineering technologies. Here, we review instructive examples living organisms solving diverse problems, propose competent navigation in arbitrary spaces as an invariant thinking about scaling cognition during evolution. We argue that our innate recognize agency intelligence unfamiliar guises lags far behind ability detect it familiar behavioral contexts. The multi-scale competency essential adaptive potentiating providing top-down control (not micromanagement) address complex disease injury. observer-focused viewpoint agnostic scale implementation, illustrating how pivoted similar explore exploit metabolic, transcriptional, morphological, finally 3D motion spaces. By generalizing concept behavior, gain perspectives on evolution, system-level biomedical interventions, construction bioengineered intelligences. This framework a first step toward relating highly embodiments, which will be progress artificial regenerative medicine, thriving world increasingly populated by synthetic, bio-robotic, hybrid beings.

Язык: Английский

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Biology, Buddhism, and AI: Care as the Driver of Intelligence

Entropy, Год журнала: 2022, Номер 24(5), С. 710 - 710

Опубликована: Май 16, 2022

Intelligence is a central feature of human beings’ primary and interpersonal experience. Understanding how intelligence originated scaled during evolution key challenge for modern biology. Some the most important approaches to understanding are ongoing efforts build new intelligences in computer science (AI) bioengineering. However, progress has been stymied by lack multidisciplinary consensus on what about regardless details its material composition or origin (evolved vs. engineered). We show that Buddhist concepts offer unique perspective facilitate consilience biology, cognitive science, toward truly diverse embodiments. In coming decades, chimeric bioengineering technologies will produce wide variety novel beings look nothing like familiar natural life forms; shall we gauge their moral responsibility our own obligations them, without touchstones standard evolved forms as comparison? Such decisions cannot be based agent made much design was involved origin. propose scope potential relationship with, so also duty toward, any being can considered light Care—a robust, practical, dynamic lynchpin formalizes goal-directedness, stress, scaling intelligence; it provides rubric that, unlike other current concepts, likely not only survive but thrive advances AI review relevant basal cognition thought, focusing size an agent’s goal space (its cone) invariant tightly links compassion. Implications range across psychology, regenerative medicine, machine learning. The Bodhisattva’s vow (“for sake all sentient life, I achieve awakening”) practical principle advancing creations ourselves.

Язык: Английский

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Synechism 2.0: Contours of a New Theory of Continuity in Bioengineering

Biosystems, Год журнала: 2025, Номер unknown, С. 105410 - 105410

Опубликована: Фев. 1, 2025

Язык: Английский

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Reflections on the AI alignment problem

AI & Society, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Язык: Английский

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