Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 31, 2025
The
ongoing
advancements
in
synthetic
biology,
employing
either
"bottom-up"
or
"top-down"
approaches
to
construct
life,
are
generating
significant
interest.
However,
the
broad
application
of
these
scientific
practices
remains
fraught
with
ethical
controversies.
Thus,
investigating
intrinsic
value
associated
life
is
crucial
for
determining
whether
and
how
should
be
constructed
utilized.
This
study
draws
upon
extends
Ronald
Sandler's
theory
value,
analyzing
subjective
from
perspectives
ecocentrism,
human
culture,
structural
properties
itself.
It
examines
objective
based
on
its
natural
purposes.
Additionally,
explores
inherent
worth
three
angles:
subjectivity,
relationships
beings.
We
conclude
that
increases
sequentially
microorganisms
plants,
invertebrates,
vertebrates,
humans.
All
forms
possess
value.
only
above
grade
has
worth;
thus,
humans
have
moral
obligations
towards
them.
BMC Bioinformatics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Апрель 25, 2024
Abstract
Background
The
Biology
System
Description
Language
(BiSDL)
is
an
accessible,
easy-to-use
computational
language
for
multicellular
synthetic
biology.
It
allows
biologists
to
represent
spatiality
and
multi-level
cellular
dynamics
inherent
designs,
filling
a
gap
in
the
state
of
art.
Developed
designing
simulating
spatial,
biological
systems,
BiSDL
integrates
high-level
conceptual
design
with
detailed
low-level
modeling,
fostering
collaboration
Design-Build-Test-Learn
cycle.
descriptions
directly
compile
into
Nets-Within-Nets
(NWNs)
models,
offering
unique
approach
spatial
hierarchical
modeling
systems.
Results
BiSDL’s
effectiveness
showcased
through
three
case
studies
on
complex
systems:
bacterial
consortium,
morphogen
system
conjugative
plasmid
transfer
process.
These
highlight
proficiency
representing
interactions
dynamics.
facilitates
compilation
designs
detailed,
simulatable
leveraging
NWNs
formalism.
This
enables
intuitive
making
advanced
tools
more
accessible
broader
range
researchers.
Conclusions
represents
significant
step
forward
languages
biology,
providing
sophisticated
yet
user-friendly
tool
systems
emphasis
Its
introduction
has
potential
transform
research
development
allowing
deeper
insights
novel
applications
understanding
manipulating
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 31, 2025
The
ongoing
advancements
in
synthetic
biology,
employing
either
"bottom-up"
or
"top-down"
approaches
to
construct
life,
are
generating
significant
interest.
However,
the
broad
application
of
these
scientific
practices
remains
fraught
with
ethical
controversies.
Thus,
investigating
intrinsic
value
associated
life
is
crucial
for
determining
whether
and
how
should
be
constructed
utilized.
This
study
draws
upon
extends
Ronald
Sandler's
theory
value,
analyzing
subjective
from
perspectives
ecocentrism,
human
culture,
structural
properties
itself.
It
examines
objective
based
on
its
natural
purposes.
Additionally,
explores
inherent
worth
three
angles:
subjectivity,
relationships
beings.
We
conclude
that
increases
sequentially
microorganisms
plants,
invertebrates,
vertebrates,
humans.
All
forms
possess
value.
only
above
grade
has
worth;
thus,
humans
have
moral
obligations
towards
them.
