Ecological Engineering and Environment Protection,
Год журнала:
2022,
Номер
2022(2/2022), С. 5 - 17
Опубликована: Ноя. 20, 2022
Biotechnology
in
its
broadest
sense
is
the
application
of
science
and
technology
to
living
organisms
produce
goods,
products
services.
It
segmented
into
10
branches,
which
white
biotechnology,
also
called
industrial
oldest,
having
roots
Neolithic
period
with
transformation
food
fermented
attributed
divine
intervention
at
that
time.
White
biotechnology
really
took
off
after
Louis
Pasteur
demonstrated
fermentation
caused
by
organisms.
This
discovery
was
followed
early
20th
century
development
large-scale
processes
exploiting
intrinsic
metabolic
properties
microorganisms,
such
as
solventogenesis
Clostridium
or
secondary
metabolism
for
penicillin
synthesis
Penicillium.
With
advent
recombinant
DNA
1970s,
a
new
era
born,
ability
genetically
manipulate
microorganisms
production
proteins
therapeutic
agents,
notably
boosted
biopharmaceutical
sector.
A
third
revolution
nowadays
occurring,
driven
strong
societal
demand
shift
from
fossil
fuel-based
economy
one
based
on
renewable
carbon
resources.
The
transition
so-called
"bioeconomy"
expected
be
slow
painful
because
it
relies
exploitation
"biological
systems"
that,
unlike
chemical
processes,
are
much
more
complex,
inefficient,
difficult
manage
still
unpredictable.
After
brief
history
I
will
present
address
this
opinion
paper
some
major
challenges
await
using
an
example
our
current
work
biosourced
methionine,
discuss
factors
could
foster
bright
future
modern
society.
The
genome
is
a
sequence
that
encodes
the
DNA,
RNA,
and
proteins
orchestrate
an
organism’s
function.
We
present
Evo,
long-context
genomic
foundation
model
with
frontier
architecture
trained
on
millions
of
prokaryotic
phage
genomes,
report
scaling
laws
DNA
to
complement
observations
in
language
vision.
Evo
generalizes
across
proteins,
enabling
zero-shot
function
prediction
competitive
domain-specific
models
generation
functional
CRISPR-Cas
transposon
systems,
representing
first
examples
protein-RNA
protein-DNA
codesign
model.
also
learns
how
small
mutations
affect
whole-organism
fitness
generates
megabase-scale
sequences
plausible
architecture.
These
capabilities
span
molecular
scales
complexity,
advancing
our
understanding
control
biology.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 27, 2024
The
genome
is
a
sequence
that
completely
encodes
the
DNA,
RNA,
and
proteins
orchestrate
function
of
whole
organism.
Advances
in
machine
learning
combined
with
massive
datasets
genomes
could
enable
biological
foundation
model
accelerates
mechanistic
understanding
generative
design
complex
molecular
interactions.
We
report
Evo,
genomic
enables
prediction
generation
tasks
from
to
scale.
Using
an
architecture
based
on
advances
deep
signal
processing,
we
scale
Evo
7
billion
parameters
context
length
131
kilobases
(kb)
at
single-nucleotide,
byte
resolution.
Trained
prokaryotic
genomes,
can
generalize
across
three
fundamental
modalities
central
dogma
biology
perform
zero-shot
competitive
with,
or
outperforms,
leading
domain-specific
language
models.
also
excels
multi-element
tasks,
which
demonstrate
by
generating
synthetic
CRISPR-Cas
complexes
entire
transposable
systems
for
first
time.
information
learned
over
predict
gene
essentiality
nucleotide
resolution
generate
coding-rich
sequences
up
650
kb
length,
orders
magnitude
longer
than
previous
methods.
multi-modal
multi-scale
provides
promising
path
toward
improving
our
control
multiple
levels
complexity.
Biological reviews/Biological reviews of the Cambridge Philosophical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 2, 2024
ABSTRACT
Freshwater
biodiversity
conservation
has
received
substantial
attention
in
the
scientific
literature
and
is
finally
being
recognized
policy
frameworks
such
as
Global
Biodiversity
Framework
its
associated
targets
for
2030.
This
important
progress.
Nonetheless,
freshwater
species
continue
to
be
confronted
with
high
levels
of
imperilment
widespread
ecosystem
degradation.
An
Emergency
Recovery
Plan
(ERP)
proposed
2020
comprises
six
measures
intended
“bend
curve”
loss,
if
they
are
widely
adopted
adequately
supported.
We
review
evidence
suggesting
that
combined
intensity
persistent
emerging
threats
become
so
serious
current
projected
efforts
preserve,
protect
restore
inland‐water
ecosystems
may
insufficient
avert
losses
coming
decades.
In
particular,
climate
change,
complex
harmful
impacts,
will
frustrate
attempts
prevent
from
already
affected
by
multiple
threats.
Interactions
among
these
limit
recovery
populations
exacerbate
declines
resulting
local
or
even
global
extinctions,
especially
low‐viability
degraded
fragmented
ecosystems.
addition
impediments
represented
we
identify
several
other
areas
where
absolute
scarcity
fresh
water,
inadequate
information
predictive
capacity,
a
failure
mitigate
anthropogenic
stressors,
liable
set
limits
on
biodiversity.
Implementation
ERP
rapidly
at
scale
through
many
dispersed
actions
focused
regions
intense
threat,
together
an
intensification
ex‐situ
efforts,
necessary
preserve
native
during
increasingly
uncertain
climatic
future
which
poorly
understood,
emergent
interacting
have
more
influential.
But
implementation
must
accompanied
improve
energy
food
security
humans
–
without
further
compromising
condition
Unfortunately,
political
policies
arrest
environmental
challenges
change
do
not
inspire
confidence
about
possible
success
ERP.
parts
world,
Anthropocene
seems
certain
include
extended
periods
uncontaminated
surface
runoff
inevitably
appropriated
humans.
Unless
there
step‐change
societal
awareness
commitment
biodiversity,
established
methods
protecting
bend
curve
enough
continued
degradation
loss.
Business Strategy & Development,
Год журнала:
2025,
Номер
8(1)
Опубликована: Фев. 26, 2025
ABSTRACT
The
transition
to
a
bio‐based
economy
promises
path
toward
reducing
greenhouse
gas
emissions
while
creating
new
business
opportunities.
However,
sustainable
implies
shifting
from
high‐volume,
low‐value
biomass
technologies
advanced
biotechnologies
that
minimize
requirements
and
negative
environmental
impacts
maximizing
economic
value‐added.
This
accelerated
innovation
process,
which
we
define
as
bioeconomy
upgrading,
will
likely
reshape
value
chain
structures
affect
benefits
distribution.
Yet,
previous
studies
have
ignored
the
relationship
between
chains
technological
change
in
bioeconomy.
Using
qualitative
approach
based
on
mapping,
develop
an
overarching
conceptual
framework
six
representative
models
of
study
nexus
innovation,
chains,
social
sustainability
is
illustrated
with
up‐to‐date
examples
validated
through
expert
survey.
We
find
upgrading
associated
shorter
more
vertically
coordinated
leading
role
by
big
firms,
higher
levels
research
cooperation
among
firms.
Finally,
argue
these
changes
organizational
coming
may
expose
most
vulnerable
actors
risks
thus
propose
some
lines
thought
regarding
potential
distributional
effects.
Restoration Ecology,
Год журнала:
2024,
Номер
32(5)
Опубликована: Апрель 15, 2024
Anthropogenic
activity
has
irreparably
altered
the
ecological
fabric
of
Earth.
The
emergence
novelty
from
diverse
drivers
change
is
an
increasingly
challenging
dimension
ecosystem
restoration.
At
same
time,
restorationist's
tool
kit
continues
to
grow,
including
a
variety
powerful
and
prevalent
technologies.
Thus,
restoration
finds
itself
at
center
intersecting
challenges.
How
should
we
respond
common
environmental
system
states
with
little
or
no
historical
precedent,
whilst
considering
appropriate
deployment
potentially
consequential
largely
untested
interventions
that
may
give
rise
organisms,
states,
and/or
processes
are
likewise
without
precedent?
We
use
term
bionovelty
encapsulate
these
themes
examine
implications
for
Foods,
Год журнала:
2023,
Номер
12(7), С. 1537 - 1537
Опубликована: Апрель 5, 2023
Pears
(Pyrus
communis
L.)
and
apples
(Malus
domestica
Borkh.)
are
two
of
the
most
popular
fruits
worldwide.
The
phenolic
compounds
they
offer
associated
with
human
health
benefits
due
to
their
antioxidant
properties.
Since
these
fruits'
by-products
not
yet
fully
exploited,
it
is
important
characterize
them,
especially
in
terms
aim
this
study
was
determine
properties
old
traditional
cultivars,
six
regional
pear
cultivars
five
apple
grown
Alcobaça
region
(Portugal).
Antioxidant
capacity
assays
were
used
evaluate
Generally,
capacity,
total
phenolics
content
(TPC),
flavonoids
(TFC)
fruit
byproducts
(both
seeds
peels)
higher
than
corresponding
mesocarp,
indicating
potential
as
sources
beneficial
compounds.
Moreover,
a
UHPLC-ToF-MS
method
optimized
validated
order
quantify
21
distinct
samples.
analytical
method's
suitability
for
quantifying
demonstrated
by
an
evaluation
linearity,
limit
detection,
quantification,
precision
accuracy.
This
composition
samples
(local)
cultivars.
highest
concentrations
phlorizin
chlorogenic
acid.
Principal
component
analysis
(PCA)
separate
species
while
emphasizing
similarities
differences.
Biotechnology Notes,
Год журнала:
2023,
Номер
4, С. 41 - 48
Опубликована: Янв. 1, 2023
Synthetic
biology
has
gained
many
interest
around
the
globe
in
last
two
decades,
not
only
due
to
its
rapid
development
but
also
potential
provide
addressable
solutions
using
standardized
design
of
biological
systems.
Considering
huge
population,
biodiversity,
and
natural
resources,
Indonesia
could
play
an
important
role
shaping
future
synthetic
towards
a
sustainable
bio-circular
economy.
Here,
we
overview
Indonesia,
especially
on
exploring
our
biodiversity.
We
discuss
some
potentials
solving
national
issues.
Furthermore,
projection
landscape
Indonesia.
In
addition,
briefly
explain
challenges
that
may
arise
during
development.
Trends in Ecology & Evolution,
Год журнала:
2023,
Номер
39(1), С. 89 - 100
Опубликована: Дек. 18, 2023
We
present
the
results
of
our
15th
horizon
scan
novel
issues
that
could
influence
biological
conservation
in
future.
From
an
initial
list
96
issues,
international
panel
scientists
and
practitioners
identified
15
we
consider
important
for
societies
worldwide
to
track
potentially
respond
to.
Issues
are
within
or
represent
a
substantial
positive
negative
step-change
with
global
regional
extents.
For
example,
new
sources
hydrogen
fuel
changes
deep-sea
currents
may
have
profound
impacts
on
marine
terrestrial
ecosystems.
Technological
advances
be
include
benchtop
DNA
printers
industrialisation
approaches
can
create
high-protein
food
from
air,
reducing
pressure
land
production.
Frontiers in Genome Editing,
Год журнала:
2024,
Номер
6
Опубликована: Июнь 13, 2024
With
scientific
progress
and
the
development
of
new
genomic
techniques
(NGTs),
spectrum
organisms
modified
for
various
purposes
is
rapidly
expanding
includes
a
wide
range
taxonomic
groups.
An
improved
understanding
which
newly
developed
products
may
be
introduced
into
market
released
environment
in
near
more
distant
future
particular
interest
policymakers,
regulatory
authorities,
risk
assessors.
To
address
this
information
need,
we
conducted
horizon
scanning
(HS)
potential
environmental
applications
four
groups
organisms:
terrestrial
animals
(excluding
insects
with
gene
drives),
fish,
algae
microorganisms.
We
applied
formal
scoping
review
methodology
comprising
structured
search
literature
followed
by
eligibility
screening,
complemented
survey
grey
literature,
websites
databases.
In
all
identified
broad
stages
basic
as
well
advanced
research,
limited
number
are
on,
or
ready
to
placed
market.
Research
on
GM
including
fish
focused
farmed
primarily
targets
traits
increase
performance,
influence
reproduction,
convey
resistance
against
diseases.
HS
were
unicellular,
than
half
articles
concerning
biofuel
production.
use
include
biocontrol
bioremediation,
also
main
From
assessor's
perspective
these
entail
multitude
possible
pathways
harm.
The
current
level
experience
amount
available
could
constitute
significant
challenge
future,
assessors
competent
authorities
urgently
need
prepare.