Backgrounds:
COVID-19
has
impaired
the
health
of
many
people
around
world
since
2019.
In
recent
years,
necroptosis
been
defined
as
a
crucial
cell
death
in
diseases
well
an
association
with
COVID-19.
However,
mechanism
remains
to
be
excavated.
Methods:
The
GEO
series
was
used
get
different
expression
genes.
Intersected
genes,
necroptosis-related
genes
were
got
and
work
on
enrichment
analysis.
LASSO
regression
algorithm
applied
selected
signature
associated
progression.
Then
we
analyzed
correlation
tissue
locations
these
Immune
infiltration
use
R
script.
To
find
regulatory
targets,
networks
TF
miRNA
built.
LINCS
database
carried
out
potential
drugs.
Results:
17
DEGs
enriched
several
progress
represented
by
cytoplasmic
transcription.
We
obtained
9
through
algorithm,
including
TP53I3,
CDK1,
MAPK14,
AURKA,
PGLYRP1,
VIL1,
TRAF5,
ZBP1,
CYLD.
These
showed
strong
correlation.
Analysis
differences
immune
patients
non-severe
severe
One
transcription
factor
5
miRNAs
identified
networks.
10
drugs
predicted
useful.
Conclusion:
Our
results
revealed
that
could
evaluate
development
COVID-19,
targets
have
treatment
potential.
findings
provide
novel
information
for
Antioxidants,
Год журнала:
2023,
Номер
12(11), С. 1942 - 1942
Опубликована: Окт. 31, 2023
Zinc
is
a
structural
component
of
proteins,
functions
as
catalytic
co-factor
in
DNA
synthesis
and
transcription
hundreds
enzymes,
has
regulatory
role
protein-DNA
interactions
zinc-finger
proteins.
For
many
years,
zinc
been
acknowledged
for
its
anti-oxidative
anti-inflammatory
functions.
Furthermore,
potent
inhibitor
caspases-3,
-7,
-8,
modulating
the
caspase-controlled
apoptosis
necroptosis.
In
recent
immunomodulatory
sepsis
COVID-19
investigated.
Both
are
related
to
various
regulated
cell
death
(RCD)
pathways,
including
Lack
may
have
negative
effect
on
immune
functions,
such
oxidative
burst,
cytokine
production,
chemotaxis,
degranulation,
phagocytosis,
RCD.
While
plasma
concentrations
decline
swiftly
during
both
COVID-19,
this
reduction
primarily
attributed
redistribution
process
associated
with
inflammatory
response.
response,
hepatic
metallothionein
production
increases
reaction
release,
which
linked
inflammation,
protein
effectively
captures
stores
liver.
Multiple
mechanisms
come
into
play,
influencing
uptake
zinc,
binding
blood
albumin
red
cells,
well
buffering
modulation
cytosolic
levels.
Decreased
levels
increasing
severity
organ
dysfunction,
prolonged
hospital
stay
increased
mortality
septic
patients.
Results
studies
focusing
these
topics
summarized
discussed
narrative
review.
Existing
evidence
currently
does
not
support
pharmacological
supplementation
patients
or
COVID-19.
Complementation
repletion
should
follow
current
guidelines
micronutrients
critically
ill
Further
research
investigating
mechanism
programmed
caused
by
invasive
infections
therapeutic
potential
could
be
worthwhile.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Ferroptosis,
a
new
type
of
programmed
cell
death
proposed
in
recent
years,
is
characterized
mainly
by
reactive
oxygen
species
and
iron-mediated
lipid
peroxidation
differs
from
death,
such
as
apoptosis,
necrosis,
autophagy.
Ferroptosis
associated
with
variety
physiological
pathophysiological
processes.
Recent
studies
have
shown
that
ferroptosis
can
aggravate
or
reduce
the
occurrence
development
diseases
targeting
metabolic
pathways
signaling
tumors,
ischemic
organ
damage,
other
degenerative
related
to
peroxidation.
Increasing
evidence
suggests
closely
linked
onset
progression
various
ophthalmic
conditions,
including
corneal
injury,
glaucoma,
age-related
macular
degeneration,
diabetic
retinopathy,
retinal
detachment,
retinoblastoma.
Our
review
current
research
on
reveals
significant
advancements
our
understanding
pathogenesis,
aetiology,
treatment
these
conditions.
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 19, 2024
The
coronavirus
disease
2019
(COVID-19)
pandemic
triggered
an
unprecedented
concentration
of
economic
and
research
efforts
to
generate
knowledge
at
unequalled
speed
on
deregulated
interferon
type
I
signalling
nuclear
factor
kappa
light
chain
enhancer
in
B-cells
(NF-κB)-driven
interleukin
(IL)-1β,
IL-6,
IL-18
secretion
causing
cytokine
storms.
translation
the
how
resulting
systemic
inflammation
can
lead
life-threatening
complications
into
novel
treatments
vaccine
technologies
is
underway.
Nevertheless,
previously
existing
role
cytoplasmatic
or
circulating
self-DNA
as
a
pro-inflammatory
damage-associated
molecular
pattern
(DAMP)
was
largely
ignored.
Pathologies
reported
‘
de
novo
’
for
patients
infected
with
Severe
Acute
Respiratory
Syndrome
Coronavirus
(SARS-CoV)-2
be
outcomes
self-DNA-driven
fact
had
been
linked
earlier
different
contexts,
e.g.,
infection
Human
Immunodeficiency
Virus
(HIV)-1,
sterile
inflammation,
autoimmune
diseases.
highlight
particularly
synergies
other
DAMPs
render
immunogenic
properties
normally
non-immunogenic
extracellular
self-DNA,
discuss
shared
features
gp41
unit
HIV-1
envelope
protein
SARS-CoV
2
Spike
that
enable
SARS-CoV-2
interact
cell
membranes,
trigger
syncytia
formation,
inflict
damage
their
host’s
DNA,
–
likely
own
benefit.
These
similarities
motivate
speculations
similar
mechanisms
those
driven
by
explain
inflammatory
contributes
some
most
frequent
adverse
events
after
vaccination
BNT162b2
mRNA
(Pfizer/BioNTech)
mRNA-1273
(Moderna)
vaccine,
i.e.,
myocarditis,
herpes
zoster,
rheumatoid
arthritis,
nephritis
hepatitis,
new-onset
lupus
erythematosus,
flare-ups
psoriasis
lupus.
hope
wider
application
lessons
learned
from
experiences
COVID-19
new
vaccines
combat
future
non-COVID-19
Viruses,
Год журнала:
2025,
Номер
17(3), С. 359 - 359
Опубликована: Фев. 28, 2025
This
study
aimed
to
identify
possible
early
biomarkers
of
mortality
among
clinical
and
biochemical
parameters,
iron
metabolism
cytokines
detected
within
24
h
from
admission
in
hospitalized
COVID-19
patients.
We
enrolled
80
patients
(40
survivors
40
non-survivors)
with
pneumonia
acute
respiratory
failure.
The
median
time
the
onset
symptoms
hospital
was
lower
non-survivors
than
(p
<
0.05).
Respiratory
failure,
expressed
as
ratio
arterial
oxygen
partial
pressure
fraction
inspired
(P/F),
more
severe
0.0001).
Comorbidities
were
similar
both
groups.
Among
parameters
cytokines,
eGFR
interleukin
(IL)-1β
found
be
significantly
0.05),
while
LDH,
IL-10,
IL-8
higher
0.0005,
p
0.05
0.005,
respectively).
other
LDH
values
distribution
showed
most
significant
difference
between
groups
LASSO
feature
selection
combined
Cox
proportional
hazards
logistic
regression
models
applied
features
distinguishing
non-survivors.
Both
approaches
highlighted
strongest
predictor,
IL-22
creatinine
emerging
model,
eGFR,
influential
model
(AUC
=
0.744
for
Cox,
0.723
regression).
In
a
manner,
we
linear
predicting
levels,
identifying
P/F
top
followed
by
IL-10
(NRMSE
0.128).
Collectively,
these
findings
underscore
LDH’s
critical
role
prediction,
key
determinants
increases
this
Italian
cohort.
Journal of Periodontal & Implant Science,
Год журнала:
2025,
Номер
55
Опубликована: Янв. 1, 2025
Odontogenic
ameloblast-associated
protein
(ODAM)
is
a
small
secretory
produced
by
the
junctional
epithelium
(JE)
and
mature
ameloblasts.
It
plays
role
in
odontogenesis
mediates
adhesion
of
JE
to
enamel.
We
used
human
gingival
epithelial
cells
evaluate
mechanism
ODAM
gene
expression
regulation
interleukin
(IL)-6.
Ca9-22,
Sa3,
HSY
were
stimulated
with
IL-6
(10
ng/mL),
after
which
total
RNA
proteins
extracted.
Real-time
polymerase
chain
reaction
Western
blot
analyses
performed
assess
levels
mRNA
protein.
Luciferase
(LUC)
assays
employed
using
LUC
constructs
varying
lengths
promoter
sequence.
Gel
mobility
shift
chromatin
immunoprecipitation
(ChIP)
conducted
investigate
binding
transcription
factors
response
elements
within
promoter.
Treatment
increased
expressions
Additionally,
it
induced
activity
gene,
while
was
suppressed
inhibitors
kinase
A,
tyrosine
kinase,
MEK1/2,
phosphatidylinositol
3-kinase,
nuclear
factor-κB,
signal
transducer
activator
(STAT)
3,
glycoprotein
130.
ChIP
revealed
that
yin
yang
1
(YY1),
CCAAT/enhancer-binding
(C/EBP)
β,
GATA
(GATA),
phospho-STAT3
YY1,
C/EBP,
GATA,
interferon-γ
activated
transcriptional
element
(GATE)
1-3
elements.
These
findings
indicate
upregulates
targeting
GATE1-3
region
gene.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 21, 2024
Introduction
Although
many
studies
have
underscored
the
importance
of
T
cells,
phenotypically
and
functionally,
fewer
studied
functions
myeloid
cells
in
COVID
disease.
In
particular,
potential
role
such
as
monocytes
low-density
neutrophils
(LDNs)
innate
responses
particular
defense
against
secondary
bacterial
infections
has
been
much
less
documented.
Methods
Here,
we
compared,
a
longitudinal
study,
healthy
subjects,
idiopathic
fibrosis
patients,
patients
who
were
either
hospitalized/moderate
(M-)
or
admitted
to
ICU
(COV-ICU)
hospitalized
for
other
reasons
(non-COV-ICU).
Results
We
show
that
an
increased
proportion
(LDNs),
which
produce
high
levels
proteases
(particularly,
NE,
MMP-8
MMP-9)
(unlike
non-COV-ICU
patients),
are
partly
responsible
causing
type
II
alveolar
cell
damage
co-culture
experiments.
addition,
showed
M-
ICU-COVID
had
reduced
responsiveness
towards
further
live
Pseudomonas
aeruginosa
(PAO1
strain)
infection,
important
pathogen
colonizing
ICU,
assessed
by
impaired
secretion
cytokines
(IL-1,
TNF,
IL-8,…).
By
contrast,
lymphoid
(in
2/type
3)
remained
high,
both
basally
post
PAO1
reflected
unimpaired
capacity
proliferate,
when
stimulated
with
anti-CD3/CD28
beads.
Discussion
Overall,
our
results
demonstrate
circulatory
biased
2/3
phenotype,
unconducive
proper
anti-viral
dual
deleterious
through
their
LDN-mediated
damaging
effect
on
(monocyte-mediated)
pathogens
P.
.
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e34694 - e34694
Опубликована: Июль 23, 2024
The
inflammatory
changes
that
underlie
the
heterogeneous
presentations
of
COVID-19
remain
incompletely
understood.
In
this
study
we
aimed
to
identify
profiles
precede
development
severe
COVID-19,
could
serve
as
targets
for
optimised
delivery
immunomodulatory
therapies
and
provide
insights
new
therapies.
Applied Sciences,
Год журнала:
2024,
Номер
14(23), С. 11048 - 11048
Опубликована: Ноя. 27, 2024
Acute
lung
injury
(ALI),
diagnosed
clinically
as
acute
respiratory
distress
syndrome
(ARDS),
refers
to
a
spectrum
of
inflammatory
processes
culminating
in
increased
permeability
the
pulmonary
alveolar–capillary
barrier
and
impaired
gas
exchange.
The
pandemic
caused
by
novel
coronavirus,
SARS-CoV-2,
has
raised
questions
similarities
differences
between
COVID-19
ALI
other
etiologies.
This
review
summarizes
current
knowledge
regarding
pathophysiology
draws
comparisons
latter
infectious
etiologies
ALI.
Indeed,
severe
is
characterized
unique
array
disease
mechanisms
including
suppression
interferon
responses,
widespread
inflammasome
activation,
altered
leukocyte
phenotypes,
hyperactive
thrombotic
activity.
Moreover,
these
manifest
clinical
progression,
which
further
differentiates
from
viral
pathogens
such
SARS,
MERS,
influenza.
These
features
bear
important
implications
for
future
therapeutic
strategies.