Boosting disassembly of π–π stacked supramolecular nanodrugs under tumor microenvironment by introducing stimuli‐responsive drug‐mates

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Авг. 20, 2024

Abstract Numerous reports have demonstrated the construction of supramolecular nanodrugs (SNDs) via π–π stacking drug molecules for antitumor applications because most drugs possess aromatic rings or other planar conjugate units. However, destruction and subsequent disassembly SNDs under tumor microenvironment (TME), which is precondition release, not been clearly described. In this work, based on a model stacked naphthoquinone SNDs, influence co‐assembled delineated. Both experimental observation computational simulation indicate that simulated TME highly depends activation energy ( ΔE dis ) neighboring molecules. Owing to high , self‐assembled greatly restricted. Meaningfully, sum series according specific stimuli TME. Thus, concept stimuli‐responsive drug‐mates proposed boosting namely foremost co‐assembly π‐conjugated with additional relatively weak interaction but responsiveness. Further reveals introduction significantly lowers thus accelerating release payloads. Holding advantages library, gives an extensive design toward heterogeneous nidus responsiveness, highlights superiority widely used strategy in constructing multifunctional SNDs.

Язык: Английский

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Supramolecular nanostructures for the delivery of peptides in cancer therapy

Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2023, Номер unknown, С. JPET - 001698

Опубликована: Окт. 12, 2023

Supramolecular nanostructured based delivery systems are emerging as a meaningful approach in treatment of cancer, offering controlled drug release and improved therapeutic efficacy. The self-assembled structures can be small molecules, polymers, peptides, proteins, which utilized functionalized to achieve tailored target specific cells, tissues, or organs. These improve the solubility stability drugs having low aqueous by encapsulating protecting them from degradation. Alongside, natural biomolecules have gained increasing attention potential candidates cancer because their biocompatibility, cytotoxicity high specificity towards tumor cells. amino acid sequences peptide molecules tunable, efficiently controlling morphology peptide-based nanosystems flexibility form supramolecular nanostructures (SNs). It is evident current literature that SNs for hold great promise future therapy, strategies personalized medicine with patient outcomes. Significance Statement This review focuses on fundamentals various mechanisms SNs. Different approaches recent reviews also presented readers.

Язык: Английский

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Electrostatic Assembly of Graphene@SiO2 Composite for Enhanced Dispersive Solid-Phase Extraction: Targeting Eight Pesticide Residues

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

As a new carbon nanomaterial, Graphene (Gr) has attracted wide attention in the field of separation and analysis because its large specific surface area strong hydrophobicity. A highly efficient selective graphene/SiO₂ (Gr/SiO₂) dispersive solid-phase extraction (d-SPE) material was prepared through electrostatic assembly. This process involved combination negatively-charged poly (sodium 4-styrenesulfonate) (PSS) mediated GS (denoted as PSS-GS) positively-charged SiO₂, modified with triethoxy silane amino. The precursor characterized using FESEM. We evaluated performance this sorbent eight pesticide residues, HPLC-MS method. demonstrated excellent recovery rates for residues under various frequency use conditions pH levels. It showed that SiO₂ Gr have synergistic effect, composite good stability reusable, Ultimately, newly developed d-SPE successfully applied fruit juice samples, yielding range 82.18 to 117.49%.

Язык: Английский

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Electrostatic Assembly of Graphene@SiO2 Composite for Enhanced Dispersive Solid-Phase Extraction: Targeting Eight Pesticide Residues

Chromatographia, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Язык: Английский

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Pyrene-tethered self-assembled supramolecular system demonstrating vesicular structures and aggregation-induced emission: synthesis, assembled studies and morphology

Journal of Chemical Sciences, Год журнала: 2024, Номер 136(4)

Опубликована: Дек. 4, 2024

Язык: Английский

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