The
mechanisms
contributing
to
age-related
deterioration
of
the
female
reproductive
system
are
complex,
however
aberrant
protein
homeostasis
is
a
major
contributor.
We
elucidated
exceptionally
stable
proteins,
structures,
and
macromolecules
that
persist
in
mammalian
ovaries
gametes
across
lifespan.
Ovaries
exhibit
localized
structural
cell-type
specific
enrichment
both
follicular
extrafollicular
environments.
Moreover,
oocytes
harbor
panel
long-lived
including
cytoskeletal,
mitochondrial,
oocyte-derived
proteins.
exceptional
persistence
these
molecules
suggest
critical
role
lifelong
maintenance
age-dependent
tissues.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 25, 2024
The
female
reproductive
system
is
one
of
the
first
to
age
in
humans,
resulting
infertility
and
endocrine
disruptions.
aging
ovary
assumes
a
fibro-inflammatory
milieu
which
negatively
impacts
gamete
quantity
quality
as
well
ovulation.
Here
we
tested
whether
systemic
delivery
anti-inflammatory
(Etanercept)
or
anti-fibrotic
(Pirfenidone)
drugs
attenuates
ovarian
mice.
We
evaluated
ability
these
decrease
expression
genes
primary
stromal
cells.
Whereas
Etanercept
did
not
block
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 13, 2024
Ovarian
aging
is
a
major
health
concern
for
women.
associated
with
reduced
span
and
longevity.
Mitochondrial
dysfunction
one
of
the
hallmarks
ovarian
aging.
In
addition
to
providing
oocytes
optimal
energy,
mitochondria
provide
co-substrate
that
drives
epigenetic
processes.
Studies
show
alterations,
both
nuclear
mitochondrial
contribute
Both,
genomes
cross-talk
each
other,
resulting
in
two
ways
orchestrated
anterograde
retrograde
response
involves
changes
compartments.
Epigenetic
alterations
causing
metabolism
impact
function.
Key
includes
acetyl
CoA,
NAD+,
ATP,
α-KG.
Thus,
enhancing
function
ovaries
may
preserve
can
lead
longevity
reproductive
better
outcomes
This
article
describes
role
mitochondria-led
epigenetics
involved
discusses
strategies
restore
reprogramming
by
preserving,
protecting,
or
promoting
Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 39 - 39
Опубликована: Дек. 31, 2024
Inflammation
disrupts
the
normal
function
of
granulosa
cells
(GCs),
which
leads
to
ovarian
dysfunction
and
fertility
decline.
Inflammatory
conditions
such
as
polycystic
ovary
syndrome
(PCOS),
primary
insufficiency
(POI),
endometriosis,
age-related
decline
are
often
associated
with
chronic
low-grade
inflammation.
Nicotinamide
mononucleotide
(NMN)
is
an
important
precursor
NAD+
has
gained
attention
for
its
potential
modulate
cellular
metabolism,
redox
homeostasis,
mitigate
This
study
investigated
protective
roles
NMN
against
lipopolysaccharide
LPS-mediated
inflammation
in
GCs.
The
results
this
experiment
demonstrated
that
LPS
had
negative
effects
on
GCs
term
reduced
viability
proliferation
rates
upregulated
production
pro-inflammatory
cytokines,
including
interleukin-1
beta
(IL-1β),
interleukin-6
(IL-6),
cyclooxygenase-2
(Cox-2),
tumor
necrosis
factor-alpha
(TNF-α).
Notably,
levels
NAD+/NADH
ratio
were
response
On
other
hand,
supplementation
restored
significantly
expression
markers
at
both
mRNA
protein
levels.
It
also
enhanced
cell
Furthermore,
apoptosis
by
downregulating
pro-apoptotic
markers,
Caspase-3,
Caspase-9,
Bax
while
upregulating
anti-apoptotic
marker
Bcl-2.
reactive
oxygen
species
ROS
improved
steroidogenesis
activity
restoring
estradiol
(E2)
progesterone
(P4)
LPS-treated
Mechanistically,
found
suppressed
activation
TLR4/NF-κB/MAPK
signaling
pathways
GCs,
regulates
inflammatory
processes.
In
conclusion,
findings
revealed
reduce
changes
modulating
metabolism
pathways.
can
be
used
a
therapeutic
agent
related
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 20, 2023
Abstract
The
mechanisms
contributing
to
age-related
deterioration
of
the
female
reproductive
system
are
complex,
however
aberrant
protein
homeostasis
is
a
major
contributor.
We
elucidated
exceptionally
stable
proteins,
structures,
and
macromolecules
that
persist
in
mammalian
ovaries
gametes
across
lifespan.
Ovaries
exhibit
localized
structural
cell-type
specific
enrichment
both
follicular
extrafollicular
environments.
Moreover,
oocytes
harbor
panel
long-lived
including
cytoskeletal,
mitochondrial,
oocyte-derived
proteins.
exceptional
persistence
these
molecules
suggest
critical
role
lifelong
maintenance
age-dependent
tissues.
One
sentence
summary
Exceptionally
as
pillars
for
health
span.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 29, 2024
Abstract
Background
At
present,
the
etiology
and
mechanism
of
ovarian
dysfunction
are
still
unclear.Recent
studies
have
indicated
a
potential
correlation
between
immunity
dysfunction.
However,
causal
relationship
immune
cells
remains
uncertain.
For
this
aiticle,we
aimed
to
figure
out
whether
changes
cell
composition
contribute
in
article.
Methods
Comprehensive
two-sample
Mendelian
randomization
analysis
was
performed
determine
role
compostitions
study.
The
data
derived
from
latest
GWAS
blood
shape
summary
statistical
Catalog,
were
obtained
IEU
Open
GWAS.
A
total
942
cases
18,228
controls
included.
variety
analytical
methods,
including
inverse
variance
weighting,
weighted
median,
MR-Egggera
etc,
utilized
explore
link
Cochran's
Q
statistics
used
evaluate
heterogeneity
instrumental
variables.
MR-Egger
MR
pleiotropic
residuals
outlier
tests
detect
horizontal
pleiotropy.
funnel
plots
scatter
visually
assess
robustness.
Results
Our
findings
suggest
that
presence
36
phenotypes
had
significant
effect
on
Among
them,
18
immunophenotypes
positively
associated
with
dysfunction,
7
B
panel,
9
T
1
monocyte
panel
NK
panel;
28
negatively
11
14
panel.
Conclusion
study
has
demonstrated
close
connection
by
genetic
background
analysis.
Further
research
is
necessary
these
as
early
predictors
well
possibility
new
preventive
strategies
therapeutic
targets.
