Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan DOI Open Access
Ewa Bomba-Warczak, Karen M Velez, Luhan T. Zhou

и другие.

Опубликована: Сен. 26, 2024

The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries gametes across lifespan. Ovaries exhibit localized structural cell-type specific enrichment both follicular extrafollicular environments. Moreover, oocytes harbor panel long-lived including cytoskeletal, mitochondrial, oocyte-derived proteins. exceptional persistence these molecules suggest critical role lifelong maintenance age-dependent tissues.

Язык: Английский

Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome DOI Creative Commons

Wing-Hong Jonathan Ho,

Maria B. Marinova,

Dave R. Listijono

и другие.

EMBO Molecular Medicine, Год журнала: 2024, Номер 16(10), С. 2583 - 2618

Опубликована: Авг. 21, 2024

Язык: Английский

Процитировано

4

Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse DOI
Farners Amargant,

Carol Magalhaes,

Michele T. Pritchard

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Язык: Английский

Процитировано

4

Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse DOI Creative Commons
Farners Amargant,

Carol Vieira,

Michele T. Pritchard

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 25, 2024

The female reproductive system is one of the first to age in humans, resulting infertility and endocrine disruptions. aging ovary assumes a fibro-inflammatory milieu which negatively impacts gamete quantity quality as well ovulation. Here we tested whether systemic delivery anti-inflammatory (Etanercept) or anti-fibrotic (Pirfenidone) drugs attenuates ovarian mice. We evaluated ability these decrease expression genes primary stromal cells. Whereas Etanercept did not block

Язык: Английский

Процитировано

3

Mitochondria: the epigenetic regulators of ovarian aging and longevity DOI Creative Commons
Shalini Mani,

Vidushi Srivastava,

Chesta Shandilya

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 13, 2024

Ovarian aging is a major health concern for women. associated with reduced span and longevity. Mitochondrial dysfunction one of the hallmarks ovarian aging. In addition to providing oocytes optimal energy, mitochondria provide co-substrate that drives epigenetic processes. Studies show alterations, both nuclear mitochondrial contribute Both, genomes cross-talk each other, resulting in two ways orchestrated anterograde retrograde response involves changes compartments. Epigenetic alterations causing metabolism impact function. Key includes acetyl CoA, NAD+, ATP, α-KG. Thus, enhancing function ovaries may preserve can lead longevity reproductive better outcomes This article describes role mitochondria-led epigenetics involved discusses strategies restore reprogramming by preserving, protecting, or promoting

Язык: Английский

Процитировано

3

CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide DOI Creative Commons

Romanthi J. Madawala,

Jasmine L. Banks, Sarah E. Hancock

и другие.

Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108248 - 108248

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Hallmarks of female reproductive aging in physiologic aging mice DOI
Julia L. Balough, Shweta S. Dipali, Karen M Velez

и другие.

Nature Aging, Год журнала: 2024, Номер 4(12), С. 1711 - 1730

Опубликована: Дек. 13, 2024

Язык: Английский

Процитировано

2

Development and validation of an LC-MS/MS method for quantifying NAD+ and related metabolites in mice sciatic nerves and its application to a nerve injury animal model DOI
Yongfen Ma, Deng Li, Zhenxia Du

и другие.

Journal of Chromatography A, Год журнала: 2024, Номер 1721, С. 464821 - 464821

Опубликована: Март 15, 2024

Язык: Английский

Процитировано

1

Nicotinamide Mononucleotide Restores NAD+ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells DOI Creative Commons
Mehboob Ahmed, Umair Riaz,

Haimiao Lv

и другие.

Antioxidants, Год журнала: 2024, Номер 14(1), С. 39 - 39

Опубликована: Дек. 31, 2024

Inflammation disrupts the normal function of granulosa cells (GCs), which leads to ovarian dysfunction and fertility decline. Inflammatory conditions such as polycystic ovary syndrome (PCOS), primary insufficiency (POI), endometriosis, age-related decline are often associated with chronic low-grade inflammation. Nicotinamide mononucleotide (NMN) is an important precursor NAD+ has gained attention for its potential modulate cellular metabolism, redox homeostasis, mitigate This study investigated protective roles NMN against lipopolysaccharide LPS-mediated inflammation in GCs. The results this experiment demonstrated that LPS had negative effects on GCs term reduced viability proliferation rates upregulated production pro-inflammatory cytokines, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), cyclooxygenase-2 (Cox-2), tumor necrosis factor-alpha (TNF-α). Notably, levels NAD+/NADH ratio were response On other hand, supplementation restored significantly expression markers at both mRNA protein levels. It also enhanced cell Furthermore, apoptosis by downregulating pro-apoptotic markers, Caspase-3, Caspase-9, Bax while upregulating anti-apoptotic marker Bcl-2. reactive oxygen species ROS improved steroidogenesis activity restoring estradiol (E2) progesterone (P4) LPS-treated Mechanistically, found suppressed activation TLR4/NF-κB/MAPK signaling pathways GCs, regulates inflammatory processes. In conclusion, findings revealed reduce changes modulating metabolism pathways. can be used a therapeutic agent related disorders.

Язык: Английский

Процитировано

1

Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan DOI Creative Commons
Ewa Bomba-Warczak, Karen M Velez, Luhan T. Zhou

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 20, 2023

Abstract The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries gametes across lifespan. Ovaries exhibit localized structural cell-type specific enrichment both follicular extrafollicular environments. Moreover, oocytes harbor panel long-lived including cytoskeletal, mitochondrial, oocyte-derived proteins. exceptional persistence these molecules suggest critical role lifelong maintenance age-dependent tissues. One sentence summary Exceptionally as pillars for health span.

Язык: Английский

Процитировано

3

Causal role of immune cells in ovarian dysfunction :a mendelian randomization study DOI Creative Commons

Ruoxin Weng,

Shuyi Ling,

Yuqing Dai

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Фев. 29, 2024

Abstract Background At present, the etiology and mechanism of ovarian dysfunction are still unclear.Recent studies have indicated a potential correlation between immunity dysfunction. However, causal relationship immune cells remains uncertain. For this aiticle,we aimed to figure out whether changes cell composition contribute in article. Methods Comprehensive two-sample Mendelian randomization analysis was performed determine role compostitions study. The data derived from latest GWAS blood shape summary statistical Catalog, were obtained IEU Open GWAS. A total 942 cases 18,228 controls included. variety analytical methods, including inverse variance weighting, weighted median, MR-Egggera etc, utilized explore link Cochran's Q statistics used evaluate heterogeneity instrumental variables. MR-Egger MR pleiotropic residuals outlier tests detect horizontal pleiotropy. funnel plots scatter visually assess robustness. Results Our findings suggest that presence 36 phenotypes had significant effect on Among them, 18 immunophenotypes positively associated with dysfunction, 7 B panel, 9 T 1 monocyte panel NK panel; 28 negatively 11 14 panel. Conclusion study has demonstrated close connection by genetic background analysis. Further research is necessary these as early predictors well possibility new preventive strategies therapeutic targets.

Язык: Английский

Процитировано

0