Much More than Nutrients: The Protective Effects of Nutraceuticals on the Blood–Brain Barrier in Diseases
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 766 - 766
Опубликована: Фев. 21, 2025
The
dysfunction
of
the
blood-brain
barrier
(BBB)
is
well
described
in
several
diseases,
and
considered
a
pathological
factor
many
neurological
disorders.
This
review
summarizes
most
important
groups
natural
compounds,
including
alkaloids,
flavonoids,
anthocyanidines,
carotenoids,
lipids,
vitamins
that
were
investigated
for
their
potential
protective
effects
on
brain
endothelium.
penetration
these
compounds
interaction
with
BBB
efflux
transporters
solute
carriers
are
discussed.
cerebrovascular
endothelium
therapeutic
target
diseases.
In
preclinical
studies
modeling
systemic
central
nervous
system
nutraceuticals
exerted
beneficial
BBB.
vivo,
they
decreased
permeability,
edema,
astrocyte
swelling,
morphological
changes
vessel
structure
basal
lamina.
At
level
endothelial
cells,
increased
cell
survival
apoptosis.
From
general
functions,
angiogenesis
levels
vasodilating
agents
demonstrated.
elevated
integrity
by
tightened
intercellular
junctions,
expression
activity
transporters,
such
as
pumps,
carriers,
metabolic
enzymes,
shown.
Nutraceuticals
enhanced
antioxidative
defense
anti-inflammatory
at
signaling
mediating
stability
activation
WNT,
PI3K-AKT,
NRF2
pathways,
inhibition
MAPK,
JNK,
ERK,
NF-κB
pathways.
represent
valuable
source
new
potentially
molecules
to
treat
diseases
protecting
Язык: Английский
Construction of fucoxanthin-loaded multi-functional pea protein isolate-fucoidan nanoparticles at neutral pH: Structural characterization and functional verification
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142966 - 142966
Опубликована: Апрель 1, 2025
Язык: Английский
Neuroprotective effects of nutraceuticals and natural products in Traumatic Brain Injury
Kalluru Bhargavi,
Niya Gowthami,
G. K. Chetan
и другие.
Neurochemistry International,
Год журнала:
2024,
Номер
unknown, С. 105904 - 105904
Опубликована: Ноя. 1, 2024
Язык: Английский
Rnf40 Exacerbates Hypertension‐Induced Cerebrovascular Endothelial Barrier Dysfunction by Ubiquitination and Degradation of Parkin
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(1)
Опубликована: Янв. 1, 2025
We
aimed
to
investigate
the
role
of
Rnf40
in
hypertension-induced
cerebrovascular
endothelial
barrier
dysfunction
and
cognitive
impairment.
employed
microarray
data
analysis
integrated
bioinformatics
databases
identify
a
novel
E3
ligase,
Rnf40,
that
targets
Parkin.
To
understand
RNF40
cell
damage,
we
used
pAAV-hFLT1-MCS-EGFP-3×Flag-mir30shRnf40
establish
an
Rnf40-deficient
model
spontaneously
hypertensive
rats
(SHRs).
also
evaluated
function,
cerebral
blood
flow,
performance.
observed
reduced
mitophagy
cells
SHRs
compared
with
Wistar-Kyoto
rats.
facilitated
K48-linked
polyubiquitination
degradation
Parkin,
thereby
inhibiting
mitophagy.
In
SHR
model,
knocking
down
restored
cells.
Additionally,
levels
tight
junction
proteins
function
improved
following
downregulation.
depletion
global
performance
flow
SHRs.
Our
findings
suggest
increased
exacerbate
by
ubiquitinating
Язык: Английский