Photoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi‐Substituted Furan Rings via Catalytic Indirect Reductive Quenching
Chemistry - An Asian Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
The
catalytic
indirect
reductive
quenching
method
is
facilitated
by
a
combination
of
Ir(III)
photoredox
and
sulfide
dual-catalysis
system.
This
study
demonstrated
for
synthesizing
multi-substituted
furans
using
photoredox/sulfide
enables
the
synthesis
various
furan
derivatives,
including
spirofurans
phthalans.
utility
this
system
was
through
gram-scale
pharmaceutical
molecule
talopram.
Mechanistic
studies
density
functional
theory
calculations
suggested
formation
sulfonium
species
via
radical
cations,
followed
intramolecular
cyclization
to
produce
desired
derivatives.
Язык: Английский
Electrosynthesis of 1,4-diene derivatives bearing cyclopentene skeleton
Yaqi Qiao,
Xiaoqing Fan,
Chengcheng Yuan
и другие.
iScience,
Год журнала:
2025,
Номер
28(3), С. 111976 - 111976
Опубликована: Фев. 10, 2025
1,n-Dual
Π
systems
including
1,4-diene
derivatives
have
been
widely
used
as
the
elegant
radical
receptors
to
promote
cascade
additions
give
highly
functionalized
polycyclic
scaffolds.
However,
tedious
and
complicated
preparation
of
former
deters
broad
utilization
compromises
practical
value.
Herein,
a
straightforward
was
developed
from
easily
accessible
alkynes
γ,δ-unsaturated
carboxylic
acids
via
electrochemical
oxidation
cyclization
Hofmann
elimination.
This
transformation
features
with
good
excellent
yields,
functional
group
compatibility,
selectivity
without
any
Zaitsev
elimination
product
detected.
Язык: Английский
Synthesis of Sulfo(xo)nium Diacylmethylides
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(27)
Опубликована: Апрель 29, 2024
Abstract
Sulfo(xo)nium
diacylmethylides
(sulfur
ylides)
are
simple,
stable,
readily
prepared,
and
versatile
synthons.
Compared
with
the
sulfo(xo)nium
monoacylmethylides,
they
can
be
compatible
more
rigorous
reaction
conditions
showcase
unique
characteristics
due
to
their
excellent
stability.
This
concept
article
provides
an
account
for
syntheses
of
diacylmethylides,
including
utilization
active
methylene
compounds,
carbene
precursors,
electron‐deficient
alkynes
as
substrates,
discussions
on
substrate
scopes,
proposed
mechanisms,
selected
product
examples,
applications.
Challenges
further
exploration
prospect
in
future
also
suggested.
Язык: Английский