Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial
EClinicalMedicine,
Год журнала:
2024,
Номер
70, С. 102517 - 102517
Опубликована: Март 14, 2024
Repurposed
drugs
with
host-directed
antiviral
and
immunomodulatory
properties
have
shown
promise
in
the
treatment
of
COVID-19,
but
few
trials
studied
combinations
these
agents.
The
aim
this
trial
was
to
assess
effectiveness
affordable,
widely
available,
repurposed
used
combination
for
which
may
be
particularly
relevant
low-resource
countries.
Язык: Английский
Real world effectiveness of early ensitrelvir treatment in patients with SARS-CoV-2, a retrospective case series
New Microbes and New Infections,
Год журнала:
2024,
Номер
62, С. 101522 - 101522
Опубликована: Окт. 30, 2024
Ensitrelvir,
a
3C-like
protease
inhibitor,
received
emergency
approval
in
Japan
November
2022
for
treating
non-hospitalized
patients
with
mild-to-moderate
COVID-19.
However,
confirmation
of
its
real-world
clinical
effectiveness
is
limited.
Язык: Английский
Comparative Analysis of RT-PCR, RT-LAMP, and Antigen Testing Strategies for Effective COVID-19 Outbreak Control: A Modeling Study
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 15, 2024
Abstract
The
COVID-19
pandemic
has
highlighted
the
crucial
role
of
testing
in
mitigating
disease
transmission.
This
study
comprehensively
evaluates
effectiveness
and
cost-efficiency
various
strategies,
including
daily
screening,
symptom-based
testing,
contact-based
using
assays
such
as
RT-PCR,
RT-LAMP,
antigen
tests.
Employing
stochastic
modeling
on
a
contact
network,
we
assessed
impact
these
strategies
outbreak
control,
case
study.
Our
findings
demonstrate
that
particularly
with
RT-PCR
significantly
reduces
transmission
risks
but
incurs
higher
costs.
In
contrast,
offers
more
cost-effective
alternative,
albeit
lower
efficacy
outbreaks.
Notably,
turnaround
time
emerges
critical
factor
than
assay
sensitivity
containing
Moreover,
combining
tracing
further
probability
scale.
To
provide
comprehensive
analysis,
also
explored
application
scenarios
where
portion
population
acquired
immunity.
results
suggest
all
symptomatic
individuals
is
most
effective
cost-efficient
approach
later
stages
an
epidemic.
These
valuable
insights
for
optimizing
to
tackle
current
future
infectious
outbreaks
effectively
efficiently.
By
adapting
based
stage
epidemic,
immunity,
available
resources,
public
health
authorities
can
design
targeted
interventions
protect
communities
while
managing
limited
resources.
Язык: Английский
Modeling the Risk of Airborne Transmission of Respiratory Viruses in Microgravity
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 6, 2024
Abstract
Airborne
transmission
is
the
most
efficient
and
widespread
route
of
viral
spread,
posing
a
significant
challenge
in
controlling
major
infectious
diseases
such
as
COVID-19
influenza.
In
microgravity
environment,
International
Space
Station
(ISS),
this
mode
requires
heightened
vigilance
preventive
measures
due
to
prolonged
suspension
virus-laden
particles,
which
increases
risk
infection.
Using
COVID
Risk
Assessment
(CARA)
tool,
we
assess
airborne
respiratory
viruses
by
simulating
emission,
dispersion,
inhalation
particles.
Our
findings
show
that
unique
conditions
allow
these
particles
remain
for
significantly
longer
periods
compared
Earth,
leading
286-fold
increase
virus
concentration
air,
resulting
nearly
twice
probability
infection
susceptible
host.
We
also
evaluated
effectiveness
measures,
found
facemasks
can
reduce
up
23%
while
continuous
HEPA
filtration
at
five
air
changes
per
hour
proves
crucial
managing
quality
minimizing
risks
reducing
99.79%.
However,
when
simulated
accounting
spaceflight-induced
immune
suppression,
increased
12%
condition
load
infected
host
8-fold
absence
protective
measures.
Although
help
mitigate
risk,
their
diminishes
carrying
high.
Enhancing
immunity
through
vaccination
or
other
interventions
vital,
potentially
14.17%
combined
with
filtration.
These
highlight
need
robust
mitigation
strategies
safeguard
health
astronauts
against
pathogens
during
future
space
missions.
Язык: Английский
Impact of COVID-19 Vaccination in Thailand: Averted Deaths and Severe Infections Across Age Groups
Tropical Medicine and Infectious Disease,
Год журнала:
2024,
Номер
9(12), С. 286 - 286
Опубликована: Ноя. 22, 2024
The
COVID-19
pandemic
has
underscored
the
pivotal
role
of
vaccines
in
mitigating
devastating
impact
virus.
In
Thailand,
vaccination
campaign
against
SARS-CoV-2
began
on
28
February
2021,
initially
prioritizing
healthcare
professionals
before
expanding
into
a
nationwide
effort
7
June
2021.
This
study
employs
mathematical
model
transmission
with
to
analyze
Thailand's
program
from
1
March
2021
31
December
2022.
We
specifically
assess
potential
loss
lives
and
occurrence
severe
infections
across
various
age
groups
hypothetical
scenario
where
were
not
administered.
By
fitting
our
officially
reported
death
data,
analysis
reveals
that
efforts
prevented
total
300,234
deaths
(95%
confidence
interval:
295,938-304,349)
averted
1.60
million
1.54-1.65
million).
Notably,
elderly
population
over
80
years
old
benefited
most
vaccination,
an
estimated
84,518
saved,
constituting
4.28%
this
group.
Furthermore,
individuals
aged
between
70
74
experienced
highest
reduction
infections,
potentially
preventing
8.35%
bracket
developing
COVID-19.
Язык: Английский