Targeted Gene Therapy: Promises and Challenges in Disease Management DOI Creative Commons

A.S. Vickram,

Sivasubaramanian Manikandan,

Titus Richard

и другие.

Journal of Bio-X Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Targeted gene therapy may revolutionize disease treatment by precisely treating genetic defects. This method targets particular cells or tissues with therapeutic genes to treat a variety of problems, including cancer, hereditary diseases, and viral infections. Viral, nonviral, genome editing techniques such as CRISPR-Cas9 are used for targeted fix modify disease-causing minimal off-target effects. The issues vector immunogenicity, mutations, delivery target persist despite tremendous progress. successful implementation is further hindered illness complexity background diversity. These difficulties require multidisciplinary cooperation, novel design, thorough preclinical clinical assessments. long-term unforeseen effects must also be considered from an ethical viewpoint. has considerable promise, but more research technological advances needed overcome limitations develop safe treatments.

Язык: Английский

Establishing a CRISPR/Cas9 genome editing framework in pigeonpea (Cajanus cajan L.) by targeting phytoene desaturase (PDS) gene disruption DOI Creative Commons
K Senthil,

Maniraj Rathinam,

Manisha Parashar

и другие.

Journal of Genetic Engineering and Biotechnology, Год журнала: 2025, Номер 23(1), С. 100465 - 100465

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

0
Classification of Vase Life Day Based on Petal Colorimetric Data in Cut Lisianthus Using AutoML DOI Creative Commons

Hye Sook Kwon,

Seong Heo

Horticulturae, Год журнала: 2024, Номер 10(10), С. 1033 - 1033

Опубликована: Сен. 29, 2024

This study investigated the potential of petal colorimetric data to classify vase life stages in cut lisianthus flowers (Eustoma grandiflorum). We analyzed changes color space over time, focusing on b* value as an indicator senescence due increasing yellowing caused by copigmentation. A comparative analysis was conducted between two cultivation methods: soil (S) and hydroponic (H) cultivation. The objective evaluate performance machine learning models trained based data. Automated exhibited better H-cultivated flowers, effectively distinguishing days within from Days 1 14 for H Cut cultivated under S conditions showed less variation 9, maintaining a relatively uniform range. made it more difficult distinguish compared These findings demonstrate that metrics can serve reliable indicators flower potentially facilitate nondestructive methods classifying stages. technology holds promise wider applications floriculture industry, improving quality control, extending various cut-flower crops.

Язык: Английский

Процитировано

1
Targeted Gene Therapy: Promises and Challenges in Disease Management DOI Creative Commons

A.S. Vickram,

Sivasubaramanian Manikandan,

Titus Richard

и другие.

Journal of Bio-X Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Targeted gene therapy may revolutionize disease treatment by precisely treating genetic defects. This method targets particular cells or tissues with therapeutic genes to treat a variety of problems, including cancer, hereditary diseases, and viral infections. Viral, nonviral, genome editing techniques such as CRISPR-Cas9 are used for targeted fix modify disease-causing minimal off-target effects. The issues vector immunogenicity, mutations, delivery target persist despite tremendous progress. successful implementation is further hindered illness complexity background diversity. These difficulties require multidisciplinary cooperation, novel design, thorough preclinical clinical assessments. long-term unforeseen effects must also be considered from an ethical viewpoint. has considerable promise, but more research technological advances needed overcome limitations develop safe treatments.

Язык: Английский

Процитировано

0