Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 22, 2024
Abstract
Cancer
stem
cells
(CSCs)
represent
a
small
yet
pivotal
subset
of
tumor
endowed
with
self-renewal
capabilities.
These
are
intricately
linked
to
progression
and
central
drug
resistance,
metastasis,
recurrence.
The
microenvironment
(TME)
encompasses
the
cancer
their
surrounding
milieu,
including
immune
inflammatory
cells,
cancer-associated
fibroblasts,
adjacent
stromal
tissues,
vasculature,
variety
cytokines
chemokines.
Within
TME,
such
as
endothelial
adipocytes,
fibroblasts
release
growth
factors,
cytokines,
chemokines,
exosomes,
which
can
either
sustain
or
disrupt
CSCs,
thereby
influencing
progression.
Conversely,
CSCs
also
secrete
affecting
various
components
TME.
Exosomes,
extracellular
vesicles
(EVs),
carry
complex
cargo
nucleic
acids,
proteins,
lipids,
playing
crucial
role
in
communication
between
This
review
primarily
focuses
on
impact
exosomes
secreted
by
(CSC-exo)
progression,
roles
maintaining
stemness,
promoting
angiogenesis,
facilitating
inducing
suppression,
contributing
resistance.
Additionally,
we
discuss
how
different
within
TME
affect
CSCs.
Finally,
explore
potential
utilizing
mitigate
detrimental
effects
target
eliminate
them.
A
thorough
understanding
exosome-mediated
crosstalk
could
provide
valuable
insights
for
developing
targeted
therapies
against
Язык: Английский
Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer Therapy
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1752 - 1752
Опубликована: Фев. 19, 2025
Hypoxia-inducible
factors
(HIFs)
are
master
regulators
of
cellular
responses
to
low
oxygen
levels
and
modulate
autophagy,
a
conserved
process
essential
for
maintaining
homeostasis.
Under
hypoxic
conditions,
HIFs
regulate
the
expression
autophagy-related
genes
influence
autophagic
flux
stress
responses.
Dysregulated
hypoxia-induced
autophagy
promotes
cancer
cell
survival,
metabolism,
metastasis,
thereby
contributing
treatment
resistance.
Targeting
HIF-mediated
pathways
or
modulating
processes
offers
potential
improve
traditional
therapies
overcome
drug
Pharmacological
inhibitors
either
alone
in
combination
with
other
treatments,
may
disrupt
pro-survival
mechanisms
within
tumor
microenvironment.
Further
research
is
needed
elucidate
intricate
interplay
between
HIF
signaling
machinery
cells.
Understanding
these
could
pave
way
novel
therapeutic
strategies
enhance
outcomes
combat
This
review
highlights
complex
relationship
development
therapy,
offering
insights
into
how
targeting
patient
outcomes.
Язык: Английский
Exploring tumor-associated macrophages in glioblastoma: from diversity to therapy
npj Precision Oncology,
Год журнала:
2025,
Номер
9(1)
Опубликована: Май 2, 2025
Glioblastoma
is
the
most
aggressive
and
lethal
cancer
of
central
nervous
system,
presenting
substantial
treatment
challenges.
The
current
standard
treatment,
which
includes
surgical
resection
followed
by
temozolomide
radiation,
offers
limited
success.
While
immunotherapies,
such
as
immune
checkpoint
inhibitors,
have
proven
effective
in
other
cancers,
they
not
demonstrated
significant
efficacy
GBM.
Emerging
research
highlights
pivotal
role
tumor-associated
macrophages
(TAMs)
supporting
tumor
growth,
fostering
resistance,
shaping
an
immunosuppressive
microenvironment.
Preclinical
studies
show
promising
results
for
therapies
targeting
TAMs,
suggesting
potential
overcoming
these
barriers.
TAMs
consist
brain-resident
microglia
bone
marrow-derived
macrophages,
both
exhibiting
diverse
phenotypes
functions
within
This
review
delves
into
origin,
heterogeneity,
functional
roles
GBM,
underscoring
their
dual
promotion
suppression.
It
also
summarizes
recent
progress
TAM-targeted
therapies,
may,
combination
with
treatments
like
immunotherapy,
pave
way
more
personalized
strategies
against
this
malignancy.
Язык: Английский
Glioblastoma-associated macrophages: A key target in overcoming Glioblastoma therapeutic resistance
Cytokine & Growth Factor Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy
Mechanisms of Ageing and Development,
Год журнала:
2025,
Номер
225, С. 112045 - 112045
Опубликована: Март 11, 2025
Cancer
remains
one
of
the
most
devastating
diseases,
severely
affecting
public
health
and
contributing
to
economic
instability.
Researchers
worldwide
are
dedicated
developing
effective
therapeutics
target
cancer
cells.
One
promising
strategy
involves
inducing
cellular
senescence,
a
complex
state
in
which
cells
exit
cell
cycle.
Senescence
has
profound
effects
on
both
physiological
pathological
processes,
influencing
systems
through
secreted
factors
that
affect
surrounding
distant
Among
these
exosomes,
small
extracellular
vesicles
play
crucial
roles
communication,
development,
defense,
can
contribute
conditions.
Recently,
there
been
increasing
interest
engineering
exosomes
as
precise
drug
delivery
vehicles,
capable
targeting
specific
or
intracellular
components.
Studies
have
emphasized
significant
role
from
senescent
progression
therapy.
Notably,
chemotherapeutic
agents
alter
tumor
microenvironment,
induce
trigger
immune
responses
exosome-mediated
cargo
transfer.
This
review
explores
intricate
relationship
between
cancer,
examining
how
different
eliminate
promote
resistance.
It
also
investigates
molecular
mechanisms
signaling
pathways
driving
highlighting
current
challenges
proposing
future
perspectives
uncover
new
therapeutic
strategies
for
treatment.
Язык: Английский
Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Март 25, 2025
Bone
marrow-derived
cells
in
the
tumor
microenvironment,
including
macrophages,
neutrophils,
dendritic
cells,
myeloid-derived
suppressor
eosinophils
and
basophils,
participate
generation,
development,
invasion
metastasis
of
tumors
by
producing
different
cytokines
interacting
with
other
cell
types,
play
a
pro-tumor
or
anti-tumor
role
regulating
immunity.
Due
to
complexity
types
microenvironment
unknown
process
development
metastasis,
cancer
treatment
achieve
better
survival
status
remains
challenging.
In
this
article,
we
summarize
effects
myeloid
on
immunity,
migration,
crosstalk
metabolism
(including
glucose
metabolism,
lipid
amino
acid
metabolism),
which
will
help
further
study
seek
targeted
therapeutic
strategies
for
patients.
Язык: Английский