Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver
Endocrinology,
Год журнала:
2025,
Номер
166(3)
Опубликована: Янв. 27, 2025
Maternal
exposure
to
ozone
during
implantation
results
in
reduced
fetal
weight
gain
rats.
Offspring
from
ozone-exposed
dams
demonstrate
sexually
dimorphic
risks
high-fat
diet
feeding
adolescence.
To
better
understand
the
adolescent
hepatic
metabolic
landscape
following
growth
restriction,
RNA
sequencing
was
performed
characterize
effects
of
ozone-induced
restriction
on
male
and
female
offspring.
Pregnant
Long-Evans
rats
were
exposed
filtered
air
or
0.8
ppm
for
4
hours
both
gestation
days
5
6
(n
=
6/group).
At
approximately
postnatal
day
48,
liver
tissue
obtained
Peri-implantation
dam
had
greater
gene
expression
offspring
than
females.
Interestingly,
heatmaps
these
differentially
expressed
genes
suggested
that
a
transcriptomic
pattern
like
Using
set
highly
female-predominant
390),
57%
upregulated
dams.
Upregulated
canonical
pathways
included
sirtuin
orexin
signaling,
estrogen
receptor
integration
energy
metabolism.
Relatively
few
altered
associated
with
endpoints
sexual
maturity,
signifying
likely
source
observed
feminization
not
attributed
sex
hormones.
This
study
provides
initial
evidence
utero
may
increase
risk
Additional
work
is
needed
further
relationship
between
developmental
undernutrition
liver.
Язык: Английский
Developmental Programming: Sex-specific Effects of Prenatal Exposure to a Real-Life Mixture of Environmental Chemicals on Liver Function and Transcriptome in Sheep.
Environmental Pollution,
Год журнала:
2025,
Номер
367, С. 125630 - 125630
Опубликована: Янв. 5, 2025
Язык: Английский
Frequent Shifts During Chronic Jet Lag Uncouple Liver Rhythms From the Light Cycle in Male Mice
Journal of Biological Rhythms,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Circadian
disruption
is
pervasive
in
modern
society
and
associated
with
increased
risk
of
disease.
Chronic
jet
lag
paradigms
are
popular
experimental
tools
aiming
to
emulate
human
circadian
experienced
during
rotating
night
shift
work.
induces
metabolic
phenotypes
tied
liver
systemic
functions,
yet
lack
a
clear
definition
for
how
rhythmic
physiology
impaired
under
these
conditions
hinders
the
ability
identify
underlying
molecular
mechanisms.
Here,
we
compared
2
common
chronic
found
that
neither
induced
arrythmicity
each
had
distinct
effects
on
rhythmicity.
Instead,
more
frequent
8-h
forward
shifts
light
schedule
severe
misalignment
non-fasted
hyperglycemia.
Every
other
day
eventually
uncoupled
behavioral
hepatic
rhythms
from
cycle,
reminiscent
free-running
conditions.
These
results
point
misalignment,
not
arrhythmicity,
as
initial
disturbance
dysfunction
environmental
highlight
considerations
interpretation
design
studies.
Язык: Английский
Twelve-hour ultradian rhythmic reprogramming of gene expression in the human ovary during aging
Journal of Assisted Reproduction and Genetics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Язык: Английский
miRNA-mediated regulation of clock gene expression in men and women with colorectal cancer and possible consequences for disease management
Biomedical Journal,
Год журнала:
2024,
Номер
unknown, С. 100784 - 100784
Опубликована: Авг. 1, 2024
The
incidence
and
mortality
of
colorectal
cancer
(CRC)
are
persistently
higher
in
men
than
women.
CRC
malignancy
is
strongly
influenced
by
small
non-coding
RNAs
(miRNAs).
Moreover,
deregulation
the
circadian
molecular
oscillator
has
been
associated
with
facilitation.
To
analyse
possible
cumulative
effects
above-mentioned
factors
on
progression,
we
focused
functions
sex-biased
miRNAs
clock
genes
per2
and/or
cry2,
which
involved
cell
cycle
control
DNA
damage
response.
Язык: Английский
The Core Circadian Clock Factor, Bmal1, Transduces Sex-specific Differences in Both Rhythmic and Nonrhythmic Gene Expression in the Mouse Heart
Function,
Год журнала:
2024,
Номер
6(1)
Опубликована: Дек. 10, 2024
It
has
been
well
established
that
cardiovascular
diseases
exhibit
significant
differences
between
sexes
in
both
preclinical
models
and
humans.
In
addition,
there
is
growing
recognition
disrupted
circadian
rhythms
can
contribute
to
the
onset
progression
of
diseases.
However,
little
known
about
sex
cardiac
clock
transcriptomes
mice.
Here,
we
show
core
genes
are
expressed
common
sexes,
but
transcriptome
very
sex-specific.
Hearts
from
female
mice
significantly
more
rhythmically
(REGs)
than
male
hearts,
temporal
distribution
REGs
was
distinctly
different
sexes.
To
test
contribution
sex-specific
gene
expression
heart,
knocked
out
factor
Bmal1
adult
cardiomyocytes.
The
were
diminished
with
cardiomyocyte-specific
loss
Bmal1.
Surprisingly,
cardiomyocyte
also
resulted
a
roughly
8-fold
reduction
number
all
differentially
hearts.
We
highlight
changes
several
cardiac-specific
transcription
factors,
including
Gata4,
Nkx2-5,
Tbx5.
While
still
much
learn,
conclude
vital
conferring
mouse
heart.
Язык: Английский
New role for cardiomyocyteBmal1in the regulation of sex-specific heart transcriptomes
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 21, 2024
It
has
been
well
established
that
cardiovascular
diseases
exhibit
significant
differences
between
sexes
in
both
preclinical
models
and
humans.
In
addition,
there
is
growing
recognition
disrupted
circadian
rhythms
can
contribute
to
the
onset
progression
of
diseases.
However
little
known
about
sex
cardiac
clock
transcriptomes
mice.
Here,
we
show
core
genes
are
expressed
common
but
transcriptome
mouse
heart
very
sex-specific.
Hearts
from
female
mice
significantly
more
rhythmically
(REGs)
than
male
hearts
temporal
pattern
REGs
was
distinctly
different
sexes.
We
next
used
a
cardiomyocyte-specific
knock
out
gene,
Язык: Английский