The Triad of Sleep, Immunity, and Cancer: A Mediating Perspective
Cells,
Год журнала:
2024,
Номер
13(15), С. 1246 - 1246
Опубликована: Июль 24, 2024
The
triadic
interplay
between
sleep,
immunity,
and
cancer
represents
a
growing
area
of
biomedical
research
with
significant
clinical
implications.
This
review
synthesizes
the
current
knowledge
on
how
sleep
influences
immune
function,
system’s
role
in
dynamics,
direct
connections
patterns
risk.
After
comprehensive
overview
interrelationships
among
these
three
domains,
mechanisms
function
are
described,
detailing
regulates
system,
effects
duration
quality
responses,
underlying
molecular
cellular
mechanisms.
Also,
complex
relationship
immunity
is
explored,
highlighting
prevention
progression,
surveillance,
tumor
microenvironment,
implications
immunodeficiency
modulation
then
presenting
epidemiological
evidence
linking
to
risk,
biological
that
influence
development,
disorders
prognosis.
mediating
highlighted,
proposing
hypothesized
pathways,
summarizing
from
experimental
studies,
evaluating
impact
interventions
outcomes.
concludes
by
discussing
future
directions,
emphasizing
potential
for
sleep-based
treatment,
integration
management
oncology
immunotherapy,
outlining
agenda.
agenda
includes
understanding
sleep–immunity–cancer
interplay,
conducting
studies
assessing
treatment
protocols,
exploring
microenvironment
interactions,
considering
policy
public
health
Through
detailed
examination
interconnected
this
underscores
critical
importance
modulating
outcomes,
advocating
interdisciplinary
strategies
harness
improved
Язык: Английский
Large muscle group movements during sleep in restless leg syndrome: neurophysiological and clinical implications
SLEEP,
Год журнала:
2024,
Номер
47(7)
Опубликована: Май 18, 2024
Abstract
Study
Objectives
Recently,
criteria
have
been
drawn
up
for
large
muscle
group
movements
during
sleep
(LMM),
defined
as
lasting
3–45
seconds
in
adults,
which
are
often
accompanied
by
changes
stage,
arousals,
and
increases
heart
rate.
The
aim
of
this
study
was
to
characterize
LMM
restless
legs
syndrome
(RLS)
order
better
evaluate
their
impact
on
the
neurophysiology
disorder
and,
therefore,
possible
clinical
implications.
Methods
Consecutive,
drug-free
patients
diagnosed
with
RLS
controls,
aged
18
years
or
more,
were
retrospectively
enrolled.
Leg
movement
activity—short-interval
(SILMS),
periodic
(PLMS),
isolated
(ISOLMS)
leg
sleep—and
detected
scored.
Results
In
total,
100
67
controls
recruited.
All
measures
significantly
higher
RLS.
A
significant
positive
correlation
found
between
ISOLMS
index
but
not
PLMS
both
groups.
showed
a
negative
total
time,
efficiency,
percentage
stages
N3
R,
well
number
awakenings,
N1
N2
only
No
either
severity.
Conclusions
Different
types
movements,
including
SILMS,
ISOLMS,
LMM,
play
somewhat
distinct
roles
Notably,
newly
recognized
category
demonstrates
associations
architecture
instability
fragmentation,
suggesting
potential
Язык: Английский
Sex‐based disparities in dopamine agonist response in patients with restless legs syndrome
Journal of Sleep Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
This
study
aimed
to
investigate
sex-related
differences
in
the
response
ropinirole
and
pramipexole
patients
with
restless
legs
syndrome
(RLS).
By
analysing
clinical
parameters
polysomnographic
(PSG)
findings,
we
sought
elucidate
potential
factors
related
sex
disparities
modulating
treatment
responses
sleep
quality
RLS.
A
total
of
41
drug-free
RLS,
aged
≥18
years,
underwent
two
consecutive
nocturnal
PSG
recordings,
without
medication
at
baseline;
before
second
night,
26
received
an
oral
dose
0.25
mg
whereas
15
0.5
ropinirole.
After
each
recording,
self-evaluated
severity
their
previous
night
symptoms
by
means
ad
hoc
visual
analogue
scale
(VAS).
At
baseline,
efficiency
percentage
Stage
N2
tended
be
higher
females
while
wakefulness
after
onset
was
significantly
males.
treatment,
leg
movements
during
(LMS),
periodic
LMS
(PLMS),
periodicity
indexes
were
lower
than
The
VAS
score
all
patients,
between
sexes.
demonstrates
a
acute
responsiveness
PLMS
dopamine
agonists
(pramipexole
ropinirole)
males
These
findings
might
explained
differential
expression
receptors,
especially
D
Язык: Английский
Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome
Movement Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Abstract
Background
Restless
legs
syndrome
(RLS)
is
a
common
sensory‐motor
disorder
characterized
by
an
urge
to
move
the
legs,
often
with
unpleasant
sensations,
particularly
during
rest.
Current
treatments
include
iron
supplementation,
dopamine
agonists,
and
opioids,
but
new
therapeutic
approaches
are
needed.
The
dysfunction
of
A11
nucleus,
which
modulates
dopaminergic
transmission
spinal
cord,
thought
play
role
in
RLS
pathophysiology.
Calcitonin
gene‐related
peptide
(CGRP),
involved
pain
modulation,
may
interact
pathways,
suggesting
RLS.
Objectives
This
study
aimed
assess
involvement
CGRP
determining
if
CGRP‐related
proteins
overexpressed
patients.
Methods
A
cross‐sectional
was
conducted
17
drug‐free
patients
(mean
age
55.8
years)
age‐
gender‐matched
controls.
Serum
samples
were
analyzed
using
liquid
chromatography‐parallel
reaction
monitoring‐tandem
mass
spectrometry
(LC‐PRM‐MS/MS)
identify
quantify
proteins.
Principal
component
analysis
(PCA)
used
differentiate
between
groups.
Results
PCA
showed
clear
differentiation
control
Among
13
identified
proteins,
10
dysregulated
patients:
8
upregulated,
2
downregulated,
among
them
notable
such
as
S100A12,
ADM,
SRSF6,
ADM2.
Conclusions
indicates
significant
related
suggests
these
roles
various
aspects
disorder.
Further
research
required
validate
findings
explore
their
clinical
implications,
including
development
treatment
options
that
specifically
address
pathways.
©
2025
Author(s).
Movement
Disorders
published
Wiley
Periodicals
LLC
on
behalf
International
Parkinson
Disorder
Society.
Язык: Английский
Association between inflammatory cytokines and disease severity in restless legs syndrome
Neurological Sciences,
Год журнала:
2024,
Номер
45(12), С. 5765 - 5770
Опубликована: Авг. 29, 2024
Язык: Английский
Transcriptome Study in Sicilian Patients with Autism Spectrum Disorder
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1402 - 1402
Опубликована: Июнь 25, 2024
ASD
is
a
complex
condition
primarily
rooted
in
genetics,
although
influenced
by
environmental,
prenatal,
and
perinatal
risk
factors,
ultimately
leading
to
genetic
epigenetic
alterations.
These
mechanisms
may
manifest
as
inflammatory,
oxidative
stress,
hypoxic,
or
ischemic
damage.
To
elucidate
potential
variances
gene
expression
ASD,
transcriptome
analysis
of
peripheral
blood
mononuclear
cells
was
conducted
via
RNA-seq
on
12
patients
13
healthy
controls,
all
Sicilian
ancestry
minimize
environmental
confounds.
A
total
733
different
statistically
significant
genes
were
identified
between
the
two
cohorts.
Gene
Set
Enrichment
Analysis
(GSEA)
Ontology
(GO)
terms
employed
explore
pathways
differentially
expressed
mRNAs.
GSEA
revealed
GO
strongly
associated
with
namely
Biological
Process
term
"Response
Oxygen-Containing
Compound".
Additionally,
Cellular
Component
pathway
"Mitochondrion"
stood
out
among
other
pathways,
predominantly
affiliated
this
specific
pathway,
implicating
involvement
mitochondrial
functions
ASD.
Among
genes,
Язык: Английский
Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship
Movement Disorders Clinical Practice,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
Patients
with
Parkinson's
Disease
(PD)
frequently
exhibit
non-motor
symptoms,
particularly
sleep
disturbances.
Sleep
disorders
in
PD
patients
are
intricately
linked
to
the
pathogenesis
and
progression
of
itself,
exacerbating
neurodegenerative
processes
worsening
patient
quality
life.
Язык: Английский
Unraveling the Pathophysiology of Restless Legs Syndrome from Multimodal MRI Techniques: A Systematic Review
Sleep Medicine,
Год журнала:
2024,
Номер
125, С. 31 - 56
Опубликована: Ноя. 13, 2024
Язык: Английский
Motor Cortex Excitability in Restless Legs Syndrome: A Systematic Review and Insights into Pathophysiology via Transcranial Magnetic Stimulation
Sleep Medicine Reviews,
Год журнала:
2024,
Номер
79, С. 102027 - 102027
Опубликована: Ноя. 20, 2024
Язык: Английский
Age‐related changes in large muscle group movements during sleep
Journal of Sleep Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 29, 2024
Summary
This
study
aims
to
investigate
large
muscle
group
movements
(LMM)
during
sleep
across
the
lifespan,
from
school‐aged
children
older
adults,
and
examine
their
relationship
with
architecture
(REM
NREM).
A
total
of
141
healthy
participants
were
included,
divided
into
five
age
groups:
(
n
=
43),
adolescents
31),
young
adults
27),
16),
24).
Polysomnography
(PSG)
was
used
record
data
LMM,
along
LMM
associated
arousals
(LMMA)
awakenings
(LMMW),
scored
according
recently
established
criteria.
The
indices
durations
analysed
for
each
group,
statistical
comparisons
made
between
groups
REM
NREM
sleep.
significantly
increased
age,
exhibiting
highest
frequency
LMMA,
LMMW.
duration
longer
in
younger
shorter
adults.
Significant
differences
patterns
observed,
particularly
where
LMMA
more
prevalent
No
significant
sex
found
groups.
showed
clear
age‐related
trends,
increasing
decreasing
advancing
age.
These
are
reflecting
fragmentation
instability.
findings
provide
important
normative
lifespan
demonstrate
that
sleep‐related
motor
activity
is
closely
linked
changes
architecture.
Язык: Английский