Experimental Neurobiology, Год журнала: 2024, Номер 33(5), С. 225 - 237

Опубликована: Окт. 31, 2024

The orbitofrontal cortex (OFC) plays a crucial role in mood disorders; however, its specific the emotional behaviors of mice remains unclear. This study investigates bidirectional control using population calcium dynamics and optogenetic manipulation OFC neurons. Fiber photometry neurons revealed that excitatory consistently responded to onset offset aversive conditions, showing decreased activation response anxiogenic stressful stimuli, including tail suspension, restraint stress, exposure center open field. selective reduced time spent field, whereas inhibitory induced opposite behavioral changes. We also provided brain-wide map for neuron activation. Our findings demonstrate play opposing roles regulation behaviors. These results provide new insights into neural mechanisms underlying suggest targeting these neuronal populations may offer novel therapeutic strategies disorders.

Язык: Английский