Cerebellum instructs plasticity in the mouse primary somatosensory cortex DOI Creative Commons

Abby Silbaugh,

Kevin P. Koster, Christian Hansel

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Sensory experiences map onto distributed neural networks and may activate plasticity processes that in some brain areas are supervised by instructive signals. What remains unknown, however, is if such signals influence beyond local circuits. Here, we show optogenetic activation of climbing fibers, which provide cerebellar plasticity, suppresses whisker response potentiation L2/3 pyramidal cells the primary somatosensory cortex mice. Using two-photon imaging chemogenetics, find controlled modulating activity levels VIP- SST-positive interneurons. Transsynaptic labeling identifies zona incerta to thalamic posterior medial nucleus projections as main pathway for output reaching cortex. Our findings neocortical not self-organized but depends on supervision olivo-cerebellar system.

Язык: Английский

Cerebellum instructs plasticity in the mouse primary somatosensory cortex DOI Creative Commons

Abby Silbaugh,

Kevin P. Koster, Christian Hansel

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Sensory experiences map onto distributed neural networks and may activate plasticity processes that in some brain areas are supervised by instructive signals. What remains unknown, however, is if such signals influence beyond local circuits. Here, we show optogenetic activation of climbing fibers, which provide cerebellar plasticity, suppresses whisker response potentiation L2/3 pyramidal cells the primary somatosensory cortex mice. Using two-photon imaging chemogenetics, find controlled modulating activity levels VIP- SST-positive interneurons. Transsynaptic labeling identifies zona incerta to thalamic posterior medial nucleus projections as main pathway for output reaching cortex. Our findings neocortical not self-organized but depends on supervision olivo-cerebellar system.

Язык: Английский

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