
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Abstract Sensory experiences map onto distributed neural networks and may activate plasticity processes that in some brain areas are supervised by instructive signals. What remains unknown, however, is if such signals influence beyond local circuits. Here, we show optogenetic activation of climbing fibers, which provide cerebellar plasticity, suppresses whisker response potentiation L2/3 pyramidal cells the primary somatosensory cortex mice. Using two-photon imaging chemogenetics, find controlled modulating activity levels VIP- SST-positive interneurons. Transsynaptic labeling identifies zona incerta to thalamic posterior medial nucleus projections as main pathway for output reaching cortex. Our findings neocortical not self-organized but depends on supervision olivo-cerebellar system.
Язык: Английский