Blood microbiome and cardiometabolic disease: insights, therapeutic strategies, and future directions
Frontiers in Bacteriology,
Год журнала:
2025,
Номер
4
Опубликована: Март 3, 2025
Cardiometabolic
diseases
(CMDs),
particularly
cardiovascular
disease
(CVD),
type
2
diabetes
mellitus
(T2DM),
and
chronic
kidney
(CKD),
emerged
as
primary
contributors
to
global
morbidity
mortality.
In
addition
traditional
factors,
recent
studies
demonstrated
that
blood
microbiomes
may
also
promote
the
development
or
progression
of
these
CMDs.
Traditionally,
was
considered
sterile;
however,
notion
a
sterile
environment
has
been
challenged
by
findings
demonstrating
presence
microbiome
in
both
healthy
states.
Although
there
tremendous
expansion
human
research,
with
hundreds
projects
underway
globally
not
received
same
level
attention
its
gut
oral
counterparts.
The
circulating
is
an
emerging
trend
drawn
high
interest
biomedical
field,
given
potential
generate
predictive
biomarkers
means
screen
for
pathogens.
This
comprehensive
review
explores
latest
advancements
emphasizing
biomarker
identification,
diagnostic
tools,
treatment
modalities,
prevention
We
delve
into
existing
challenges
present
future-oriented
strategy
using
advanced
methods.
Deciphering
microbiome’s
role
could
lead
classification
patient
subgroups,
enabling
precision
microbiota-based
therapies.
Язык: Английский
Blood Bacterial Microbiota of the American Bison (Bison bison) in Northern Mexico: A Reference for Health and Conservation
Ruminants,
Год журнала:
2025,
Номер
5(1), С. 10 - 10
Опубликована: Март 4, 2025
The
emerging
field
of
study
blood
microbiota
reveals
the
presence
bacteria
in
healthy
animals.
In
endangered
species
such
as
American
bison
(Bison
bison),
analysis
this
is
crucial
for
conservation,
changes
these
communities
or
development
pathogens
may
affect
their
health
and
compromise
herd
viability.
Here,
we
analyzed
compared
bacterial
adult
juvenile
Mexico
(Janos,
Chihuahua),
identifying
those
taxa
with
potential
pathogenicity
individuals.
Blood
samples
were
collected
from
12
bison.
V3–V4
region
16S
rRNA
gene
was
amplified,
next-generation
sequencing
subsequently
performed
on
Illumina
NovaSeq
platform.
observed
individuals
(Firmicutes,
Proteobacteria,
Bacteroidota,
Actinobacteria,
Fusobacteriaceae,
Lachnospiraceae,
Oscillospiraceae,
Ruminococcaceae)
have
been
previously
reported
to
be
abundant
rumen
feces
most
notable
difference
Mycoplasma
wenyonii,
which
significantly
enriched
juveniles
adults.
New
technologies
can
practically
applied
improve
management
conservation
vulnerable
Язык: Английский
Common microbial signatures in blood and their amplification in clinical disorders
Gut Microbes Reports,
Год журнала:
2025,
Номер
2(1), С. 1 - 19
Опубликована: Март 19, 2025
Язык: Английский
Distinct blood and oral microbiome profiles reveal altered microbial composition and functional pathways in myocardial infarction patients
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 14, 2025
Introduction
The
blood
microbiome,
increasingly
recognized
as
a
distinct
microbial
niche,
may
originate
partly
from
oral
translocation.
We
systematically
compared
circulating
and
microbiome
profiles
between
healthy
individuals
myocardial
infarction
(MI)
patients
to
identify
disease-associated
signatures.
Methods
current
study
recruited
20
participants,
including
10
controls
with
MI.
Blood
Saliva
samples
were
collected
each
participant
analyze
the
association
in
MI
using
16S
rRNA
gene
sequencing.
Results
showed
significantly
greater
alpha
diversity
than
(p<0.05),
but
beta
did
not
differ
significantly.
had
higher
levels
of
Firmicutes,
Bacteroidota,
Actinobacteriota,
genus
Bacteroides,
lower
Proteobacteria,
whereas
was
dominated
by
Veillonella,
Prevotella_7.
LEfSe
analysis
revealed
taxa-Actinobacteria
Enterobacterales
controls.
In
contrast,
microbiota
subjects
enriched
Rothia,
Micrococcaceae,
Micrococcales,
while
no
taxa
associated
Both
microbiomes
significant
functional
pathway
differences
(KEGG)
groups.
Additionally,
signatures
correlated
clinical
demographic
markers.
Discussion
Our
demonstrates
that
harbors
characterized
specific
pathways
rather
merely
reflecting
bacterial
These
findings
suggest
play
an
active
role
pathology
Furthermore,
we
identified
associations
these
disease
This
highlights
potential
importance
understanding
mechanisms
underlying
its
diagnostic
or
therapeutic
implications.
Язык: Английский
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10611 - 10611
Опубликована: Окт. 2, 2024
Type
1
Diabetes
Mellitus
(T1DM)
is
a
chronic
autoimmune
disease
that
results
in
the
destruction
of
pancreatic
β
cells,
leading
to
hyperglycaemia
and
need
for
lifelong
insulin
therapy.
Although
genetic
predisposition
environmental
factors
are
considered
key
contributors
T1DM,
exact
causes
remain
partially
unclear.
Recent
evidence
has
focused
on
relationship
between
gut,
oral
cavity,
immune
regulation,
systemic
inflammation.
In
individuals
with
changes
gut
microbial
composition
commonly
observed,
indicating
dysbiosis
may
contribute
dysregulation.
Gut
can
influence
system
through
increased
intestinal
permeability,
altered
production
short
chain
fatty
acids
(SCFAs),
interactions
mucosal
system,
potentially
triggering
response.
Similarly,
development
inflammation
thus
progression
T1DM.
A
comprehensive
understanding
these
relationships
essential
identification
biomarkers
early
diagnosis
monitoring,
as
well
therapies
aimed
at
restoring
balance.
This
review
presents
synthesis
current
research
connection
T1DM
microbiome
dysbiosis,
focus
microbiomes
pediatric
populations.
It
explores
potential
mechanisms
by
which
contributes
pathogenesis
examines
microbiome-based
therapies,
including
probiotics,
prebiotics,
synbiotics,
faecal
microbiota
transplantation
(FMT).
complex
highlights
longitudinal
studies
monitor
over
time,
investigate
causal
specific
species
develop
personalised
medicine
approaches.
Язык: Английский