Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 2061 - 2061
Опубликована: Март 18, 2025
Background/Objectives:
Regenerative
therapies
have
gained
interest
in
orthopedic
applications
for
their
potential
to
enhance
tissue
regeneration,
functional
recovery,
and
pain
modification.
This
review
evaluates
the
clinical
efficacy
of
platelet-rich
plasma
(PRP),
mesenchymal
stem
cells
(MSCs),
peptide-based
treatments,
biomimetic
materials
care,
with
a
focus
on
reduction
outcomes.
Methods:
A
structured
literature
search
PubMed
(January
2009–January
2025)
identified
160
studies.
After
applying
inclusion
criteria
prioritizing
randomized
controlled
trials
(RCTs)
trials,
59
studies
were
included:
20
PRP,
MSCs,
10
peptide
therapies,
7
biomimetics.
Data
extraction
focused
risk
bias
assessed
using
Cochrane
Risk
Bias
(RoB)
tool
ROBINS-I
tool.
random-effects
meta-regression
analysis
was
conducted
evaluate
impact
therapy
type,
sample
size,
reported
Results:
Meta-regression
MSC
as
most
effective
intervention
(β
=
8.45,
p
<
0.05),
PRP
showing
moderate
improvements,
demonstrating
lowest
effect.
provided
short-term
relief,
particularly
acute
injuries
tendon
repair,
though
inconsistencies
preparation
methods
limited
success
chronic
conditions.
demonstrated
cartilage
regeneration
early
osteoarthritis
improvement,
but
high
costs
ethical
concerns
remain
barriers
widespread
adoption.
Peptide-based
materials,
including
engineered
scaffolds
autologous
protein
solutions,
showed
promise
infection
control
wound
healing,
further
research
is
needed
optimize
dosing,
delivery
methods,
long-term
safety.
Conclusions:
offer
significant
reliable
regenerative
effects,
providing
symptomatic
treatments
emerging
promising
adjuncts.
However,
standardized
protocols
large-scale
are
establish
improve
translation
broader
Язык: Английский
Navigating the Complexities of Diabetic Foot Ulcers: From Pathophysiology to Advanced Treatment Strategies
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106852 - 106852
Опубликована: Март 1, 2025
Язык: Английский
Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency
Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1257 - 1257
Опубликована: Май 21, 2025
Background:
Intraovarian
platelet-rich
plasma
(PRP)
has
emerged
as
a
novel
intervention
at
the
intersection
of
reproductive
medicine
and
regenerative
biology.
As
women
with
diminished
ovarian
reserve
(DOR),
poor
response
to
stimulation,
or
premature
insufficiency
(POI)
seek
fertility
solutions,
PRP
provides
scientifically
plausible—yet
exploratory—strategy
restore
augment
function.
The
proposed
pathways
include
stimulation
local
stem
cells,
tissue
remodeling,
neoangiogenesis,
potential
reawakening
dormant
follicles.
Methods:
This
narrative
review
critically
synthesizes
existing
literature
on
intraovarian
therapy.
It
draws
from
published
case
series,
pilot
studies,
preclinical
data
evaluate
biological
rationale,
clinical
outcomes,
current
limitations
use
in
DOR
POI.
Results:
Early
findings,
albeit
limited
modest
series
investigations,
reveal
promising
outcomes
such
improved
markers,
menstrual
restoration,
infrequent
spontaneous
pregnancies
who
had
previously
been
unresponsive
treatment.
However,
variability
preparation
techniques,
patient
selection
criteria,
outcome
measures
limits
generalizability
these
results.
Conclusions:
While
presents
an
exciting
frontier
medicine,
absence
defined
protocols,
controlled
trials,
long-term
safety
underscores
its
experimental
nature.
Future
research
should
focus
standardizing
methodologies,
conducting
randomized
elucidating
molecular
mechanisms
underlying
observed
effects
establish
PRP’s
role
managing
Язык: Английский
Platelet-Rich Plasma for Knee Osteoarthritis: A Comprehensive Narrative Review of the Mechanisms, Preparation Protocols, and Clinical Evidence
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(11), С. 3983 - 3983
Опубликована: Июнь 5, 2025
Background:
Platelet-rich
plasma
(PRP)
is
increasingly
utilized
for
managing
knee
osteoarthritis
(KOA),
yet
its
clinical
value
remains
debated
due
to
the
variability
in
preparation
protocols
and
outcome
measures.
Methods:
This
narrative
review
synthesizes
current
evidence
from
40
high-quality
studies
published
between
2013
March
2025,
including
randomized
controlled
trials,
systematic
reviews,
meta-analyses.
The
biological
mechanisms,
effectiveness,
safety,
implementation
challenges
of
PRP
therapy
KOA
are
examined.
Results:
injections—particularly
leukocyte-poor
PRP—demonstrate
superior
pain
relief
functional
improvement
compared
hyaluronic
acid
corticosteroids,
especially
patients
with
mild
moderate
(Kellgren–Lawrence
grades
I–III).
However,
heterogeneity
formulations
(platelet/leukocyte
content
activation
protocols),
injection
regimens,
follow-up
durations
limits
direct
comparability
across
studies.
Evidence
placebo-controlled
trials
shows
inconsistent
long-term
benefits,
some
failing
demonstrate
superiority
over
saline
beyond
6–12
months.
GRADE
assessment
rates
overall
certainty
as
moderate.
appears
safe,
few
adverse
events
reported,
but
costly
variably
reimbursed.
Guidelines
major
societies
remain
cautious
or
inconclusive.
Conclusions:
a
promising,
well-tolerated
option
early
KOA.
standardization
protocols,
patient
selection
criteria,
reporting
essential
improve
guide
practice.
Язык: Английский