The Journal of Physiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Abstract Alzheimer's disease (AD) is a growing global health challenge with limited pharmacological treatments. Epidemiological studies link regular physical activity lower risk of AD and cognitive decline in general, whereas randomized controlled trials show that aerobic exercise slows progression improves function. However the underlying mechanisms remain incompletely understood. In this review we discuss five likely intervention points through which may influence pathology: (1) reducing neuroinflammation amyloid beta (Aβ) aggregation, (2) enhancing clearance Aβ aggregates, (3) increasing neuronal resilience, (4) promoting hippocampal neurogenesis (5) strengthening reserve. Understanding these mechanistic links are most to drive AD‐protective effects could help refine lifestyle‐based interventions complement treatments inform future prevention strategies. image
Язык: Английский