ChemistrySelect, Год журнала: 2024, Номер 9(44)
Опубликована: Ноя. 1, 2024
Abstract Diabetes mellitus is a chronic condition characterized by impaired insulin production or utilization, leading to serious complications such as diabetic foot ulcers (DFUs). DFUs are wounds with high levels of inflammatory cytokines, arterial occlusion, and persistent infection, often resulting in significant morbidity. Traditional treatment methods, including debridement, offloading, infection control, have shown limited success, prompting the exploration novel therapeutic strategies. Insulin, known for its role glucose metabolism, also possesses wound‐healing properties promoting cell proliferation, protein synthesis, modulating inflammation. However, systemic administration not ideal due hypoglycemia risks difficulties achieving concentrations at wound sites. This review focuses on advanced drug delivery systems topical application dressings. Various platforms, hydrogels, nanoparticles, liposomes, microemulsions been developed optimize bioavailability, protect it from degradation, ensure controlled release. These aim enhance management addressing multifactorial nature healing patients. The provides comprehensive overview current advancements, evaluates efficacy these preclinical clinical studies, discusses challenges future perspectives this field. By highlighting potential innovative approaches, underscores promise improving patient outcomes.
Язык: Английский
Процитировано
2Solar-powered compact thermal energy storage system with rapid response time and rib-enhanced plate via techniques of CFD, ANN, and GA
Journal of Energy Storage, Год журнала: 2024, Номер 105, С. 114807 - 114807
Опубликована: Ноя. 27, 2024
Язык: Английский
Процитировано
2Recent Advances in Potential Biomedical Applications of
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)
Опубликована: Ноя. 29, 2024
ABSTRACT MXene‐based hydrogels represent a significant advancement in biomedical material science, leveraging the unique properties of 2D MXenes and versatile functionality hydrogels. This review discusses recent developments integration into hydrogel matrices, focusing on their applications such as wound healing, drug delivery, antimicrobial activity, tissue engineering, biosensing. MXenes, due to remarkable electrical conductivity, mechanical robustness, tunable surface chemistry, enhance properties, responsiveness environmental stimuli. Specifically, have shown great promise accelerating healing through photothermal effects, delivering drugs controlled manner, serving antibacterial agents. Their also enables targeted cancer therapies, including chemodynamic facilitated by high conductivity properties. Despite promising progress, challenges ensuring biocompatibility optimizing synthesis for large‐scale production remain. aims provide comprehensive overview current state applications, highlighting ongoing advancements potential future directions these multifunctional materials.
Язык: Английский
Процитировано
2Non-contact vision-based response reconstruction and reinforcement learning guided evolutionary algorithm for substructural condition assessment
Mechanical Systems and Signal Processing, Год журнала: 2024, Номер 224, С. 112017 - 112017
Опубликована: Окт. 8, 2024
Язык: Английский
Процитировано
2Path planning for a UGV using Salp Swarm Algorithm
Опубликована: Апрель 19, 2024
Язык: Английский
Процитировано
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