International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114503 - 114503
Опубликована: Март 26, 2025
Язык: Английский
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Авг. 8, 2023
Microglial activation and subsequent inflammatory responses are critical processes in aggravating secondary brain injury after intracerebral hemorrhage (ICH). Pterostilbene (3’, 5’-dimethoxy-resveratrol) features antioxidant anti-inflammation properties has been proven neuroprotective. In this study, we aimed to explore whether could attenuate neuroinflammation experimental ICH, as well underlying molecular mechanisms. Here, a collagenase-induced ICH mice was followed by intraperitoneal injection of (10 mg/kg) or vehicle once daily. PTE-treated performed significantly better than vehicle-treated controls the neurological behavior test ICH. Furthermore, our results showed that reduced lesion volume neural apoptosis, alleviated blood-brain barrier (BBB) damage edema. RNA sequencing experiments ICH-induced microglial proinflammatory activities were markedly suppressed treatment. With regard mechanisms, identified anti-inflammatory effects relied on remodeling mitochondrial dynamics microglia. Concretely, reversed downregulation OPA1, promoted fusion, restored normal morphology, fragmentation superoxide microglia OxyHb Moreover, conditionally deleting OPA1 largely countered alleviating inflammation, BBB damage, edema impairment following summary, provided first evidence is promising agent for mice, uncovered novel regulatory relationship between OPA1-mediated fusion.
Язык: Английский
Процитировано
11
Frontiers in Neuroscience, Год журнала: 2023, Номер 17
Опубликована: Окт. 27, 2023
Neurons in the central nervous system are among most metabolically active cells body, characterized by high oxygen consumption utilizing glucose both aerobically and anaerobically. have an abundance of mitochondria which generate adequate ATP to keep up with metabolic demand. One consequence oxidative phosphorylation mechanism synthesis, is generation reactive species produces cellular injury as well damage mitochondria. Mitochondria respond fusion serves ameliorate through genetic complementation. also undergo fission meet increased energy Loss compensated biogenesis new Damaged removed mitophagy, autophagic process, damaged surrounded a membrane form autophagosome ultimately fuses lysosome resulting degradation faulty Dysregulation mitophagy has been reported several disorders, including, Alzheimer’s disease Parkinson’s disease. Recent studies point aberrant ocular neurodegenerative disorders could be important contributor etiology/pathology. This review article highlights some recent findings that dysregulation it’s underlying mechanisms diseases, glaucoma, age-related macular degeneration diabetic retinopathy.
Язык: Английский
Процитировано
11
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Янв. 12, 2024
A subset of major depressive disorder (MDD) is characterized by immune system dysfunction, but the intracellular origin these changes remains unclear. Here we tested hypothesis that abnormalities in endoplasmic reticulum (ER) stress, inflammasome activity and mitochondrial biogenesis contribute to development systemic inflammation MDD. RT-qPCR was used measure mRNA expression key organellar genes from peripheral blood mononuclear cells (PBMCs) isolated 186 MDD 67 healthy control (HC) subjects. The comparative CT (2
Язык: Английский
Процитировано
3
Function, Год журнала: 2024, Номер 5(4)
Опубликована: Янв. 1, 2024
Abstract Microparticles (MPs) are secreted by all cells, where they play a key role in intercellular communication, differentiation, inflammation, and cell energy transfer. P2X7 receptor (P2X7R) activation extracellular ATP (eATP) causes large MP release affects their contents cell-specific fashion. We investigated functional impact microglial cells from P2X7R-WT or P2X7R-KO mice, as well mouse lines characterized for high (N13-P2X7RHigh) low (N13-P2X7RLow) P2X7R expression. stimulation promoted of mixed population enriched with naked mitochondria. Released mitochondria were taken up incorporated into the mitochondrial network recipient P2X7R-dependent NLRP3 itself also delivered to cells. Microparticle transfer increased level conferred pro-inflammatory phenotype. These data show that is master regulator organelle trafficking immune
Язык: Английский
Процитировано
3
International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114503 - 114503
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0