Current Opinion in Clinical Nutrition & Metabolic Care,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 17, 2024
Purpose
of
the
review
New
dietary
trends
driven
by
environmental
and
health
considerations
will
undoubtedly
lead
to
emergence
novel
food
allergens.
Assessment
allergenic
risk
new
or
modified
protein-containing
sources
ingredients,
as
well
surveillance
emerging
allergies,
is
then
required.
Recent
findings
Developments
in
silico
vitro
models
apprehending
protein
capacity
cross-react
with
other
homologous
proteins
induce
a
de
novo
allergic
sensitization
are
ongoing
better
integrate
multiple
parameters
such
3D
structural
information
major
histocompatibility
complex
class
II
(MHC-II)
presentation
propensity.
However,
effects
matrices
processing
still
need
be
addressed
these
models.
Consequently,
clinical
postmarket
remain
critical
importance
alert
on
emergent
which
modulated
regional
practices.
Summary
Monitoring
allergens
requires
close
collaborations
between
allergologists,
consumers,
patient
associations
safety
authorities.
We
also
get
consensus
an
acceptable
level
that
offers
possibility
develop
market
innovative
sustainable
products.
Expert Review of Vaccines,
Год журнала:
2024,
Номер
23(1), С. 715 - 729
Опубликована: Июль 23, 2024
The
use
of
novel
adjuvants
in
human
vaccines
continues
to
expand
as
their
contribution
preventing
disease
challenging
populations
and
caused
by
complex
pathogens
is
increasingly
understood.
AS01
a
family
liposome-based
vaccine
Adjuvant
Systems
containing
two
immunostimulants:
3-
European Journal of Immunology,
Год журнала:
2025,
Номер
55(2)
Опубликована: Фев. 1, 2025
Interactions
between
T-
and
B
cells
in
the
germinal
center
reaction
are
instrumental
for
initiation,
maintenance,
downregulation
of
human
adaptive
immune
response,
leading
to
production
antigen-specific
antibodies
long-lasting
immunological
memory.
Replicating
system
remains
challenging,
with
an
over-reliance
on
animal
models
limited
translational
accuracy.
There
is
increasing
need
new
tools
that
accurately
model
function.
This
review
evaluates
existing
2D
3D
vitro
ex
vivo
their
ability
reproduce
reaction,
a
particular
focus
B-cell
interaction.
We
conclude
although
current
able
replicate
certain
features
no
completely
complex
GC
process.
outline
challenges
recreating
fully
functional
suggest
future
directions
research
improve
models,
ultimately
bringing
us
closer
reproducing
lymph
node.
Cell Reports Medicine,
Год журнала:
2025,
Номер
unknown, С. 101981 - 101981
Опубликована: Фев. 1, 2025
Antigenic
peptide-based
mRNA
vaccines
have
been
explored
for
immunotherapeutic
use
in
various
types
of
cancer
because
their
advantages
activating
durable
and
specific
immune
responses.
However,
role
modulating
tumor
metastasis
is
still
unclear.
Here,
we
identify
a
conserved
linear
epitope-based
peptide,
Ma3P,
located
the
proteolytic
region
major
histocompatibility
complex
(MHC)
class
I-related
chain
A
(MICA)
α3
further
design
mCM10-L,
an
vaccine
that
encodes
carrier
protein
CRM197
10
tandem
repeats
Ma3P.
We
demonstrate
vaccination
with
mCM10-L
induces
production
antibodies
block
MICA/B
α1/2
shedding,
activate
CD8+
T
cells
natural
killer
(NK)
cells,
significantly
inhibit
MICA/B+
mice.
Furthermore,
stimulation
triggers
to
promote
MICA/B-mediated
killing
in-vitro-interacting
human
organoid
model
humanized
Our
results
indicate
potential
clinical
application
prospects
vaccine.
Interdisciplinary Perspectives on Infectious Diseases,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
This
paper
explores
the
transformative
potential
of
integrating
artificial
intelligence
(AI)
in
diagnosis
and
prognosis
infectious
diseases.
By
analyzing
diverse
datasets,
including
clinical
symptoms,
laboratory
results,
imaging
data,
AI
algorithms
can
significantly
enhance
early
detection
personalized
treatment
strategies.
reviews
how
AI-driven
models
improve
diagnostic
accuracy,
predict
patient
outcomes,
contribute
to
effective
disease
management.
It
also
addresses
challenges
ethical
considerations
associated
with
AI,
data
privacy,
algorithmic
bias,
equitable
access
healthcare.
Highlighting
case
studies
recent
advancements,
underscores
AI's
role
revolutionizing
management
its
implications
for
future
healthcare
delivery.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 17, 2025
Melanoma
is
a
highly
invasive
malignancy
with
poor
prognoses
in
advanced
stages.
Developing
risk
model
that
can
accurately
assess
prognosis
and
guide
personalized
treatment
crucial
for
improving
the
clinical
management
of
melanoma.
This
study
aims
to
develop
validate
an
immune-based
prognostic
melanoma
through
comprehensive
bioinformatics
analysis.
We
collected
transcriptomic
data
from
multiple
public
databases
identified
9
immune
features
significantly
associated
using
single-sample
Gene
Set
Enrichment
Analysis
(ssGSEA)
Cox
regression.
These
were
utilized
construct
model,
which
was
subsequently
validated
relevant
bulk
datasets
single-cell
GEO
database,
encompassing
diverse
patient
populations
sample
types.
The
effectively
stratified
patients
into
high-risk
low-risk
groups
distinct
survival
outcomes.
Further
analysis
revealed
significant
associations
between
genomic
heterogeneity
indicators,
such
as
tumor
mutational
burden
(TMB),
loss
heterozygosity
(LOH),
checkpoint
gene
expression.
robustness
confirmed
data,
highlighting
key
genes
potential
therapeutic
relevance.
Our
findings
provide
reliable
tool
novel
insights
treatment,
emphasizing
need
further
validation.
