Опубликована: Янв. 1, 2024
Язык: Английский
Circulation Research, Год журнала: 2024, Номер 134(12), С. 1808 - 1823
Опубликована: Июнь 6, 2024
Mounting experimental and clinical evidence has revealed that adaptive immune mechanisms targeting myocardial antigens are triggered by different forms of cardiac injury impact disease progression. B T lymphocytes recognize specific via unique receptors generated through a somatic rearrangement process generates potential repertoire 10
Язык: Английский
Процитировано
4
The Journal of Microbiology, Год журнала: 2025, Номер 63(1), С. e:2409007 - e:2409007
Опубликована: Янв. 24, 2025
Язык: Английский
Процитировано
0
EMBO Molecular Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Abstract In 2020–2021, a “mysterious illness” struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis of the environmental samples we reveal presence marine dinoflagellate Vulcanodinium rugosum and its associated cyclic imine toxins. Specifically, show that toxin PortimineA, strongly enriched samples, impedes ribosome function human keratinocytes, which subsequently activates stress kinases ZAKα P38 promotes nucleation NLRP1 inflammasome, leading to release IL-1β/IL-18 pro-inflammatory cytokines cell death. Furthermore, cell-based models highlight naturally occurring mutations P38-targeted sites are unable respond PortimineA exposure. Finally, development use organotypic skins zebrafish demonstrate ZAKα-NLRP1 axis drives skin necrosis inflammation. Our results exemplify threats health caused emerging toxins identify NRLP1 as important pharmacological targets mitigate toxicity.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 305, С. 141190 - 141190
Опубликована: Фев. 16, 2025
Язык: Английский
Процитировано
0
Journal of Molecular and Cellular Cardiology, Год журнала: 2025, Номер 202, С. 13 - 23
Опубликована: Март 6, 2025
Inflammasomes are multiprotein complexes of the innate immune system that mediate inflammatory responses to infection and local systemic stress tissue injury. The principal function is facilitate caspase-1 auto-activation subsequently maturation release effectors interleukin (IL)-1β IL-18. atrial-specific NLRP3 inflammasome a unifying causal feature atrial fibrillation (AF) development, progression recurrence after ablation. Many AF-associated risk factors co-morbidities converge mechanistically on activation this central signaling platform. This review presents historical conceptual development distinct its potential involvement in AF. We follow early observations linking inflammation with AF, emergence an atrial-intrinsic operating within not just cells but also resident fibroblasts cardiomyocytes. outline key developments understanding how effector IL-1β contribute causally cellular tissue-level arrhythmogenesis different pathological settings, candidate therapeutic concepts verified preclinical models cardiomyopathy
Язык: Английский
Процитировано
0
Experimental Eye Research, Год журнала: 2025, Номер 254, С. 110338 - 110338
Опубликована: Март 14, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 28, 2025
Sepsis is defined as a condition related to infection that manifests with multiorgan dysfunction, representing life-threatening state. Consequently, severe complications frequently occur, liver injury being one of the most prevalent serious sepsis. Liver dysfunction during sepsis serves an independent predictor mortality. This review provides comprehensive overview current research on sepsis-induced (SILI), encompassing clinical manifestations, diagnostic criteria, pathogenesis and therapeutic strategies associated this condition. SILI may manifest hypoxic hepatitis due ischemia shock, cholestasis resulting from abnormal bile metabolism, or duct sclerosis. The pathophysiology involves intricate interactions among inflammatory response, oxidative stress, cell death. All these factors complicate treatment represent potential targets for intervention. Furthermore, addresses limitations inherent in conventional therapies currently employed managing emphasizes novel targeted aimed at addressing fundamental mechanisms underlying
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 2, 2025
Multiple sclerosis (MS) is widely acknowledged as a chronic inflammatory autoimmune disorder characterized by central nervous system (CNS) demyelination and neurodegeneration. The hyperactivation of immune responses recognized pivotal factor contributing to the pathogenesis progression MS. Among various reactions, researchers have increasingly focused on inflammasome, complex proteins. initiation activation inflammasome are intricately involved in onset Notably, NLRP3 most extensively studied member complex, closely linked with This review will delve into roles Additionally, therapeutic strategies targeting for treatment MS, including natural compounds, autophagy regulators, other small molecular be detailed this review.
Язык: Английский
Процитировано
0
Viruses, Год журнала: 2024, Номер 16(8), С. 1272 - 1272
Опубликована: Авг. 9, 2024
Viruses are obligate intracellular pathogens as their replication depends on the metabolism of host cell. The induction cellular suicide, known programmed cell death (PCD), has potential to hinder viral and act a first line defense against pathogens. Apoptosis, necroptosis, pyroptosis three important PCD modalities. Different signaling pathways involved in execution, they also differ ability cause inflammation. Cytomegaloviruses (CMV), beta-herpesviruses with large double-stranded DNA genomes, encode great variety immune evasion genes, including several suppressors. While CMV inhibitors apoptosis necroptosis have been studied for years, inhibitor identified characterized only recently. Here, we describe how human murine interfere apoptosis, pathways. We discuss importance different forms containment spread vivo.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 135876 - 135876
Опубликована: Сен. 23, 2024
Previous studies by our group and others have highlighted the critical role of hyperinflammation in pathogenicity duck hepatitis A virus 1 (DHAV-1), an avian picornavirus that has caused significant devastation industry worldwide for decades. However, precise mechanisms which DHAV-1 infection regulates inflammatory responses, particularly production IL-1β, remain poorly understood. In this study, we demonstrate triggers NF-κB- NLRP3 inflammasome-mediated IL-1β production. Mechanistically, infection, its replication translation, disrupts cellular homeostasis Ca
Язык: Английский
Процитировано
1