Trends in Neurosciences, Год журнала: 2024, Номер 47(12), С. 965 - 967
Опубликована: Окт. 22, 2024
Язык: Английский
Nature Neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Язык: Английский
Процитировано
2
Neurotherapeutics, Год журнала: 2025, Номер unknown, С. e00535 - e00535
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Science Advances, Год журнала: 2025, Номер 11(6)
Опубликована: Фев. 5, 2025
Macrophages accumulate lipid droplets (LDs) under stress and inflammatory conditions. Despite the presence of LD-loaded macrophages in many tissues, including brain, their contribution to neurodegenerative disorders remains elusive. This study investigated role metabolism Alzheimer’s disease (AD) by assessing brain macrophages, microglia border-associated (BAMs), an AD mouse model. Particularly, BAMs activated CD11c + localized near β amyloid (Aβ) plaques exhibited a pronounced lipid-associated gene signature high LD load. Having observed that elevated intracellular content correlated inversely with microglial phagocytic activities, we subsequently inhibited formation specifically CX3CR1 using inducible APP-KI/ Fit2 i Δ M φ transgenic We demonstrated reducing remarkably improved ability. Furthermore, lowering LDs consistently enhanced efferocytosis capacities notably reduced Aβ deposition parenchyma. Therefore, mitigating accumulation provides perspectives for treatment.
Язык: Английский
Процитировано
1
Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)
Опубликована: Фев. 21, 2025
Abstract Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows immune cells to infiltrate central nervous system (CNS), worsening neuroinflammation and progression. We examine recent findings on interactions between CNS-resident microglia, forming self-perpetuating inflammatory cycle leading neuronal dysfunction. Moreover, this emphasizes developments dysregulation factors from both periphery CNS, their impact With ongoing development new therapeutic strategies, underscores importance modulating CNS therapy.
Язык: Английский
Процитировано
1
Life Sciences, Год журнала: 2024, Номер 356, С. 123018 - 123018
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
5
Brain Behavior and Immunity, Год журнала: 2025, Номер 128, С. 266 - 275
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
ABSTRACT The meninges are a set of connective tissue layers that surround the central nervous system, protecting brain from mechanical shock, supporting its buoyancy, guarding it infection and injury, maintaining homeostasis. Despite their critical role, molecular identity, developmental origins, functional properties cell types populating remain poorly characterized. This is in large part due to lack type specific markers difficulty visualizing studying these structures through thick mammalian skull. Here, we show zebrafish, genetically experimentally accessible vertebrate, possesses an easily imaged mammalian-like meninges. Anatomical cellular characterization composition via histology, electron microscopy, confocal imaging shows adult zebrafish complex multilayered with double-layered dura mater intricate leptomeningeal layers. Using single transcriptomics, define identities meningeal populations, including unique ependymin ( epd )-expressing population constitutes major component barrier essential for development survival. These findings support use as useful comparative model meninges, provide foundational description future research, identify new Leptomeningeal Barrier Cell serves primary epithelial leptomeninges.
Язык: Английский
Процитировано
0
Mucosal Immunology, Год журнала: 2024, Номер 17(5), С. 1102 - 1113
Опубликована: Июль 27, 2024
The olfactory mucosa is important for both the sense of smell and as a mucosal immune barrier to upper airway brain. However, little known about how system mediates conflicting goals neuronal maintenance inflammation in this tissue. A number cell populations reside within yet we have understanding these resident cells functionally interact with chemosensory environment. Identifying interactions will allow therapeutic manipulations that treat disorders such post-viral dysfunction. Macrophages are most prevalent type uninflamed here, identify two distinct tissue macrophage murine mucosa. P2ry12hi macrophages transcriptionally specialized neuron interactions, closely associated bodies, long-term residents, phagocytose debris, including neurons. Conversely, MHC Class IIhi dedicated cytokine production antigen presentation, localized primarily lamina propria, more rapidly replaced by blood monocytes, produce chemokines response viral infection. We further show signatures present human biopsies, P2ry12-like reduced patients loss following COVID-19. Together, data regulate neurons initiate response, contributing our immunity tissue-resident biology.
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 8, 2024
Abstract Spatial transcriptomics has revolutionized our understanding of cellular network dynamics in aging and disease by enabling the mapping molecular organization across various anatomical locations. Despite these advances, current methods face significant challenges throughput cost, limiting their utility for comprehensive studies. To address limitations, we introduce IRISeq (Imaging R econstruction using Indexed Seq uencing), a optics-free spatial platform that eliminates need predefined capture arrays or extensive imaging, allowing rapid cost-effective processing multiple tissue sections simultaneously. Its capacity to reconstruct images based solely on sequencing local DNA interactions allows profiling tissues without size constraints varied resolutions. Applying , examined gene expression thirty brain regions both adult aged mice, uncovering region-specific changes associated with aging. Further cell type-centric analysis further identified age-related subtypes intricate are distinct certain niches, emphasizing unique aspects different regions. The affordability simplicity position it as versatile tool biological systems. One Sentence Summary: an innovative method, uncovers aging-related focal
Язык: Английский
Процитировано
1
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Окт. 31, 2024
The role of myeloid cells (granulocytes and monocytes) in neurodegeneration neurodegenerative disorders (NDD) is indisputable. Here we discuss the roles diseases, recent advances biofluid imaging biomarker research with a focus on methods that can be used clinic. For this review, evidence from three diseases will included, Alzheimer's disease (AD), Parkinson's (PD), multiple sclerosis (MS). We potential for these biomarkers to humans suspected NDD as prognostic, diagnostic, or monitoring tools, identify knowledge gaps literature, propose approaches further elucidate better utilize understanding treatment NDD.
Язык: Английский
Процитировано
1