More than microglia: myeloid cells and biomarkers in neurodegeneration

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 31, 2024

The role of myeloid cells (granulocytes and monocytes) in neurodegeneration neurodegenerative disorders (NDD) is indisputable. Here we discuss the roles diseases, recent advances biofluid imaging biomarker research with a focus on methods that can be used clinic. For this review, evidence from three diseases will included, Alzheimer's disease (AD), Parkinson's (PD), multiple sclerosis (MS). We potential for these biomarkers to humans suspected NDD as prognostic, diagnostic, or monitoring tools, identify knowledge gaps literature, propose approaches further elucidate better utilize understanding treatment NDD.

Язык: Английский

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Reimagining the meninges from a neuroimmune perspective: a boundary, but not peripheral

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Ноя. 15, 2024

Recent advances in neuroscience have transformed our understanding of the meninges, layers surrounding central nervous system (CNS). Two key findings advanced understanding: researchers identified cranial bone marrow as a reservoir for meningeal immune cells, and rediscovered brain lymphatic system. Once viewed merely protective barrier, meninges are now recognized dynamic interface crucial neuroimmune interactions. This shift perspective highlights their unique role maintaining CNS balance, shaping development, regulating responses to injury disease. review synthesizes latest insights into anatomy function, with focus on newly structures such dural-associated lymphoid tissues (DALT) arachnoid cuff exit (ACE) points. We also examine diverse cell populations within interactions CNS, underscoring emerging view active participants immunity. Finally, we outline critical unanswered questions about immunity, proposing directions future research. By addressing these knowledge gaps, aim deepen meninges' health disease, potentially paving way novel therapeutic approaches.

Язык: Английский

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Mononuclear phagocytes in autoimmune neuroinflammation

Trends in Immunology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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CAMs in command: aging brain macrophages fine-tune stroke immune responses

Trends in Neurosciences, Год журнала: 2024, Номер 47(12), С. 965 - 967

Опубликована: Окт. 22, 2024

Язык: Английский

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