Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Gasdermin
(GSDM)-mediated
pyroptosis
involves
the
induction
of
mitochondrial
damage
and
subsequent
release
DNA
(mtDNA),
which
is
anticipated
to
activate
cGAS-STING
pathway,
thereby
augmenting
antitumor
immune
response.
However,
challenges
lie
in
effectively
triggering
cancer
cells
subsequently
enhancing
activation
with
specificity.
Herein,
we
developed
intelligent
self-cascaded
pyroptosis-STING
initiators
cobalt
fluoride
(CoF2)
nanocatalysts
for
catalytic
metalloimmunotherapy.
CoF2
a
semiconductor
structure
enzyme-like
activity
generated
substantial
amount
reactive
oxygen
species
(ROS)
under
stimulation
by
endogenous
H2O2
exogenous
ultrasound.
Importantly,
discovered
that
Co-based
nanomaterials
themselves
induce
cells.
Therefore,
initially
acted
as
inducers,
caspase-1/GSDMD-dependent
via
Co2+
ROS,
leading
mtDNA
release.
Subsequently,
were
further
utilized
STING
agonists
specifically
capable
detecting
pathway.
These
cascade
events
triggered
robust
response,
modulating
immunosuppressive
tumor
microenvironment
into
an
immune-supportive
state,
providing
favorable
support
therapy.
This
innovative
strategy
not
only
significantly
impeded
growth
primary
but
also
elicited
response
augment
efficacy
checkpoint
inhibitors
preventing
distant
progression.
Overall,
this
study
proposed
self-cascade
activating
amplifying
pathway
specificity
mediated
pyroptosis,
representing
valuable
avenue
future
Язык: Английский
Modulating the Electronic Structure of MnNi2S3 Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen‐Immunotherapy
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Hydrogen
(H
2
)
therapy
has
demonstrated
antitumor
effect,
but
the
therapeutic
efficacy
is
restricted
by
low
solubility
and
nontarget
delivery
of
H
.
Electrolysis
O
electrocatalysts
sustainably
releases
enormous
amounts
inspires
precise
for
tumor
therapy.
Herein,
manganese‐doped
Ni
S
3
nanoelectrodes
(MnNi
NEs)
are
designed
electrocatalytic
activation
immunity
to
effectively
potentiate
‐immunotherapy.
atoms
featuring
empty
3d
orbitals
reduce
initial
energy
barrier
hydrogen
evolution
reaction
(HER)
promoting
adsorption
O.
Moreover,
Mn
with
different
electronegativity
modulate
electronic
structure
facilitate
desorption
generated
,
thus
enhancing
HER
activity
MnNi
NEs.
Based
on
high
activity,
controllable
(EHT)
achieved
in
a
voltage‐dependent
manner.
Mechanistically,
NE‐mediated
EHT
induces
mitochondrial
dysfunction
oxidative
stress,
which
subsequently
activates
pyroptosis
through
typical
ROS/caspase‐1/GSDMD
signaling
pathway.
Furthermore,
enhances
infiltration
CD8
+
T
lymphocytes
into
tumors
reverses
immunosuppressive
microenvironment.
This
work
demonstrates
an
electrocatalyst
synergistic
gas‐immunotherapy,
may
spark
electrocatalyst‐based
strategies.
Язык: Английский
A Highly Potent Os@Au‐TPA Coordination Structure‐Based Sonosensitizer for Tumor Sono‐Immunotherapies
Pengfei Xie,
Xiao Rong,
Xuelian Qin
и другие.
Advanced Functional Materials,
Год журнала:
2024,
Номер
35(2)
Опубликована: Ноя. 18, 2024
Abstract
Ultrasound
(US)
becomes
an
appealing
modality
for
stimulating
or
amplifying
immune
responses
during
cancer
therapy,
which
is
also
termed
sono‐immunotherapy.
However,
the
clinical
prospect
has
not
been
fully
realized
due
to
scarcity
of
efficient
sonosensitizers.
Herein,
first
time
a
novel
Os‐doped
Au‐tri(pyridin‐4‐yl)
amine
coordination
structure
(Os@Au‐TPA)‐based
sonosensitizer
originally
designed
and
synthesized
sono‐immunotherapy
breast‐metastasized
tumors.
Impressively,
Os@Au‐TPA
shows
much
higher
US‐mediated
1
O
2
‐producing
activity
than
Au‐TPA
as
well
other
traditional
sonosensitizers,
example,
≈41.6
folds
ce6,
19.5
times
Protoporphyrin
IX
(PpIX),
12.0
Indocyanine
Green
(ICG),
11.1
Iron
phthalocyanine
(Pc(Fe)).
The
can
only
generate
abundant
ROS
upon
US
irradiation
implement
sonodynamic
therapy
(SDT),
cell
apoptosis
further
immunogenic
death,
but
alleviate
hypoxia
promote
polarization
M2
M1
macrophages
enhance
tumor
immunogenicity.
As
result,
when
combined
with
PD‐L1
antibody,
it
remodels
immunosuppressive
microenvironment,
achieves
concurrent
sonodynamic‐triggered
activation,
eradicates
both
original
distant‐metastasized
tumors
efficiently.
This
work
provides
new
strategy
construct
potent
sonosensitizers
from
pyridine‐metal
structures
proves
that
high
performance
are
crucial
in
boosting
Язык: Английский
NaCe0.7FX:Gd0.1,Tb0.2 nanoscintillator as a new sonosensitizer for potentiating cancer sonodynamic-immune therapy
Chemical Engineering Journal,
Год журнала:
2024,
Номер
497, С. 154566 - 154566
Опубликована: Авг. 5, 2024
Язык: Английский
Antimony Component Schottky Nanoheterojunctions as Ultrasound‐Heightened Pyroptosis Initiators for Sonocatalytic Immunotherapy
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 21, 2024
Abstract
Pyroptosis,
an
inflammatory
modality
of
programmed
cell
death
associated
with
the
immune
response,
can
be
initiated
by
bioactive
ions
and
reactive
oxygen
species
(ROS).
However,
ion‐induced
pyroptosis
lacks
specificity,
further
exploration
other
that
induce
in
cancer
cells
is
needed.
Sonocatalytic
therapy
(SCT)
holds
promise
due
to
its
exceptional
penetration
depth;
however,
rapid
recombination
electron‐hole
(e
−
‐h
+
)
pairs
complex
tumor
microenvironment
(TME)
impede
broader
application.
Herein,
we
discovered
antimony
(Sb)‐based
nanomaterials
induced
cells.
Therefore,
Schottky
heterojunctions
containing
Sb
component
(Sb
2
Se
3
@Pt)
were
effectively
designed
constructed
via
situ
growth
platinum
(Pt)
nanoparticles
(NPs)
on
semiconductor
narrow
band
gaps,
which
utilized
as
US‐heightened
initiators
highly
effective
boost
SCT‐immunotherapy.
Under
US
irradiation,
excited
electrons
transferred
from
nanorods
(NRs)
co‐catalyst
Pt
junctions,
bending
prevented
electron
backflow
achieved
efficient
ROS
generation.
Moreover,
pores
oxidized
depleted
overexpressed
GSH
TME,
potentially
amplifying
The
biological
effects
@Pt
nanoheterojunction
itself
combined
sonocatalytic
amplification
oxidative
stress
significantly
Caspase‐1/GSDMD‐dependent
SCT
treatment
not
only
restrained
proliferation
but
also
potent
memory
responses
suppressed
recurrence.
Furthermore,
integration
this
innovative
strategy
checkpoint
blockade
(ICB)
elicited
a
systemic
augmenting
therapeutic
impeding
abscopal
tumors.
Overall,
study
provides
opportunities
explore
pyroptosis‐mediated
Язык: Английский
Injectable hydrogel assisted formation of hydroxyl radical generating bioreactor enables photothermally enhanced chemodynamic and immunotherapy
Chemical Engineering Journal,
Год журнала:
2024,
Номер
500, С. 157141 - 157141
Опубликована: Окт. 28, 2024
Язык: Английский
An Oral Nanovaccine Secreted by Genetically Engineered and Ultrasound‐Responsive Bacteria for Colon Cancer Immunotherapy
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Abstract
Colorectal
cancers
represent
a
major
global
morbidity
and
mortality
burden,
neccessitating
improved
treatment
paradigms.
In
this
work,
an
ingestible,
genetically
engineered
Escherichia
coli
(
E.
)
1917
termed
“
(AH1‐CDA‐Co1)”
is
designed
that
upon
ultrasound
exposure
secretes
bacterial
outer
membrane
vesicles
(OMV)
incorporating
the
AH1
tumor
rejection
epitope,
enzyme
producing
stimulator
of
interferon
genes
(STING)
agonist
CDA,
microfold
cell‐targeting
peptide
Co1.
For
oral
administration,
polydopamine
system
(iPDA)
coating
on
bacteria
exploited
to
resist
acidic
condition
in
stomach,
increase
survival,
prolong
intestinal
transit
time.
Upon
harmless
exposure,
sustained
secretion
OMV
vaccines
triggered
efficiently
cross
epithelium.
Both
cyclic
GMP–AMP
synthase
(cGAS)‐STING
TLR4
innate
immune
signaling
pathways
are
activated,
triggering
long‐term
antigen‐specific
responses
overcome
immunosuppressive
microenvironment.
subcutaneous
orthotopic
murine
colorectal
models,
(AH1‐CDA‐Co1)@iPDA
inhibits
growth
prolongs
survival
without
recurrence.
also
recurrence
postoperative
colonrectal
model
lymph
node
metastases.
Taken
together,
demonstrates
potent
vaccine
for
colon
cancer
immunotherapy.
Язык: Английский
Ultrasound‐Enabled Sonogenetics: Pioneering Advances in Cancer Theranostics
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
The
diagnosis
and
treatment
of
cancer
face
significant
challenges.
Thus,
precise
controllable
methods
for
effective
tumor
management
are
required.
Sonogenetics
which
combines
ultrasound
technology
with
genetic
engineering
provides
a
promising
solution.
This
approach
utilizes
the
non‐invasive
nature
deep
tissue
penetration
capabilities
to
enable
diagnostics
targeted
therapies
cancer.
review
explores
roles
sonogenetics‐mediated
in
theranostics.
fundamental
properties
mechanisms
underlying
sonogenetics
first
introduced.
Then,
this
work
summarizes
representative
applications
therapy,
including
cell‐based
therapies,
bacteria‐based
eradication
cells.
Additionally,
diagnosis,
focusing
on
engineered
gas
vesicles
(GVs)
situ
generation
GVs
diagnostic
purposes
presented.
Finally,
challenges
clinical
translation
potential
well
discussed.
Язык: Английский