Biological Significance of the Erythrocyte Sedimentation Rate (ESR) Test: Pandemic Reemergence of Robin Fåhraeus’s “Fibrin Coagula” – Historical Overview DOI Creative Commons
Donald R. Forsdyke

Опубликована: Фев. 24, 2025

In the pre-antibiotic era, infections were usually more frequent and serious than today. Robin Fåhraeus (1888-1958) examined erythrocyte sedimentation rate (ESR) test for infections, which was normally carried out _in vitro _with freshly drawn blood. His extensive studies on mechanism physiological significance of enhanced aggregates (rouleaux) in disease included vivo _simulation. This led him to propose an explanation finding long white strips (“fibrin coagula”) within blood vessels those who had died from infections. The surge pandemic times has likely kindled a reemergence. He further speculated both that weak aggregation red cells (RBCs) followed liberation water molecules their surfaces, importance aggregation, induced by changes serum proteins (not necessarily antibodies), extended beyond clinic. modern these have immunologically significant entropic interpretations infection-associated aggregations, whether cellular (e.g., RBC) or molecular (i.e., macromolecular polymerizations). Thus, rouleaux formation displays process at level can proceed parallel less visible level. It been proposed that, when intracellular, aggregations would discriminate between self not-self crowded cytosol. Favoured associated pyrexia, this could lead, mechanisms be determined, preferential loading peptides deemed foreign presentation as MHC complexes specific clones immune cells.

Язык: Английский

Retrospective Clinical Investigation into the Association Between Abnormal Blood Clotting, Oral Anticoagulant Therapy, and Medium-Term Mortality in a Cohort of COVID-19 Patients DOI Creative Commons
Giorgia Dinoi, Maria Vittoria Togo, Pietro Guida

и другие.

Biomedicines, Год журнала: 2025, Номер 13(3), С. 535 - 535

Опубликована: Фев. 20, 2025

Background/Objectives: People affected by COVID-19 are exposed to abnormal clotting and endothelial dysfunction, which may trigger thromboembolic events. This study aimed at retrospectively investigating whether oral anticoagulant therapy (OAT), encompassing either direct anticoagulants (DOACs), mainly apixaban, or the vitamin K antagonist (VKA) warfarin, could have impacted medium-term mortality in a cohort of SARS-CoV-2 patients. Methods: Among 1238 patients, hospitalized from 17 March 2020 15 June 2021, 247 survivors deceased within 90 days hospitalization were matched 1:1 based on age, sex, intensive care unit (ICU) admission three days. Conditional logistic regression was used estimate associations means odds ratio (OR) with 95% confidence interval (CI). Results: A univariate analysis suggested that OAT, no differently subcutaneous low-molecular-weight heparins (LMWHs) during hospitalization, has significant impact (p value > 0.05) mortality. multivariate analysis, limited baseline variables (i.e., comorbidities pharmacotherapies hospital admission) showing association < revealed that, compared patients living had cancer histories (OR 1.75, CI 1.06–2.90, p = 0.029) suffered asthma 2.25, 1.13–4.47, 0.021). In contrast, heart failure (HF), atrial fibrillation (AF), arteriopathy, chronic obstructive pulmonary disease (COPD), kidney (KF), which, found be associated endpoint 0.05), lost significance analysis. Therapy aldosterone antagonists also appeared 2.49, 1.52–4.08, 0.001); whereas, D supplementation beneficial. Although not conclusive, search into Eudravigilance database, combined consulting digital predictive platform (PLATO, polypharmacology prediction), potential off-target activities, might contribute increasing severity infection. Conclusions: retrospective clinical furnished evidences other pharmacological treatments course.

Язык: Английский

Процитировано

1
Biological Significance of the Erythrocyte Sedimentation Rate (ESR) Test: Pandemic Reemergence of Robin Fåhraeus’s “Fibrin Coagula” – Historical Overview DOI Creative Commons
Donald R. Forsdyke

Опубликована: Фев. 24, 2025

In the pre-antibiotic era, infections were usually more frequent and serious than today. Robin Fåhraeus (1888-1958) examined erythrocyte sedimentation rate (ESR) test for infections, which was normally carried out _in vitro _with freshly drawn blood. His extensive studies on mechanism physiological significance of enhanced aggregates (rouleaux) in disease included vivo _simulation. This led him to propose an explanation finding long white strips (“fibrin coagula”) within blood vessels those who had died from infections. The surge pandemic times has likely kindled a reemergence. He further speculated both that weak aggregation red cells (RBCs) followed liberation water molecules their surfaces, importance aggregation, induced by changes serum proteins (not necessarily antibodies), extended beyond clinic. modern these have immunologically significant entropic interpretations infection-associated aggregations, whether cellular (e.g., RBC) or molecular (i.e., macromolecular polymerizations). Thus, rouleaux formation displays process at level can proceed parallel less visible level. It been proposed that, when intracellular, aggregations would discriminate between self not-self crowded cytosol. Favoured associated pyrexia, this could lead, mechanisms be determined, preferential loading peptides deemed foreign presentation as MHC complexes specific clones immune cells.

Язык: Английский

Процитировано

0