Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions

American Journal of Clinical Dermatology, Год журнала: 2023, Номер 24(4), С. 521 - 540

Опубликована: Май 4, 2023

Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus [SLE]) or the skin only (cutaneous [CLE]). Typical combinations clinical, histological and serological findings define clinical subtypes CLE, yet there is high interindividual variation. Skin lesions arise in course triggers such as ultraviolet (UV) light exposure, smoking drugs; keratinocytes, cytotoxic T cells plasmacytoid dendritic (pDCs) establish self-perpetuating interplay between innate adaptive immune system pivotal for pathogenesis CLE. Therefore, treatment relies on avoidance UV protection, topical therapies (glucocorticosteroids, calcineurin inhibitors) rather unspecific immunosuppressive immunomodulatory drugs. Yet, advent licensed targeted SLE might also open new perspectives management The heterogeneity CLE be attributable to individual variables we speculate prevailing inflammatory signature defined by either cells, B pDCs, strong lesional type I interferon (IFN) response, above suitable predict therapeutic response treatment. pretherapeutic assessment infiltrate could stratify patients with refractory T-cell-directed (e.g. dapirolizumab pegol), B-cell-directed belimumab), pDC-directed litifilimab) IFN-directed anifrolumab). Moreover, Janus kinase (JAK) spleen tyrosine (SYK) inhibitors broaden armamentarium near future. A close interdisciplinary exchange rheumatologists nephrologists mandatory optimal best strategy.

Язык: Английский

---

Overview of Oxidative Stress in Systemic Lupus Erythematosus

Antioxidants, Год журнала: 2025, Номер 14(3), С. 303 - 303

Опубликована: Март 1, 2025

Systemic lupus erythematosus (SLE) is an autoimmune disease that frequently diagnosed in female patients, caused by multiple interacting factors. It has a complex pathogenesis which can affect almost any organ, from the kidneys to cardiovascular, pulmonary, neurological, osteoarticular, and hematological systems. The present narrative review seeks elucidate role of reactive oxygen species (ROS) SLE. central question guiding this study what extent these serum protein modifications correlate with activity organ damage characterized decreased apoptosis increased necrosis T cells NETosis granulocytes. Given impact SLE diagnosis on one's life, aims evaluate intricacies oxidative stress its relevance treatment disease. Topics such as understanding processes stress, their damaging pathways, biomarkers, future assistance clinical decisions will be discussed article. accurate determination biomarkers taught improve both management disease, while antioxidant therapy may open new door for treatment.

Язык: Английский

---

Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sjögren's syndrome

Chinese Medical Journal, Год журнала: 2023, Номер unknown

Опубликована: Апрель 26, 2023

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with high prevalence and possible poor prognosis. Though the pathogenesis of pSS has not been fully elucidated, B cell hyperactivity considered as one fundamental abnormalities in patients. It long identified that Janus kinases-signal transducer activator transcription (JAK-STAT) signaling pathway contributes to rheumatoid arthritis lupus erythematosus. Recently, increasing numbers studies have provided evidence JAK-STAT also an important role via direct or indirect activation cells. Signal 1 (STAT1), STAT3, STAT5 activated by various cytokines ribonucleic acid contribute development, respectively synergically. These results reveal potential application kinase inhibitors for treatment pSS, which may fundamentally improve quality life prognosis patients pSS.

Язык: Английский

---

A comprehensive analysis of type 1 interferon gene signatures in systematic lupus erythematosus and prediction of the crucial susceptible factor for Sjögren syndrome

Clinical and Experimental Medicine, Год журнала: 2023, Номер 23(8), С. 4731 - 4743

Опубликована: Авг. 5, 2023

Язык: Английский

---