Diretrizes Brasileiras de Hipertensão Arterial – 2020

Arquivos Brasileiros de Cardiologia, Год журнала: 2021, Номер 116(3), С. 516 - 658

Опубликована: Март 1, 2021

Content 1. Definition, Epidemiology, and Primary Prevention 528 1.1 Definition of Hypertension […] Brazilian Guidelines – 2020

Язык: Английский

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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Ageing Research Reviews, Год журнала: 2021, Номер 71, С. 101422 - 101422

Опубликована: Авг. 13, 2021

Язык: Английский

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Metabolism of vascular smooth muscle cells in vascular diseases

AJP Heart and Circulatory Physiology, Год журнала: 2020, Номер 319(3), С. H613 - H631

Опубликована: Авг. 7, 2020

Vascular smooth muscle cells (VSMCs) are the fundamental component of medial layer arteries and essential for arterial physiology pathology. It is becoming increasingly clear that VSMCs can alter their metabolism to fulfill bioenergetic biosynthetic requirements. During vascular injury, switch from a quiescent “contractile” phenotype highly migratory proliferative “synthetic” phenotype. Recent studies have found switching driven by metabolic switch. Metabolic pathways, including aerobic glycolysis, fatty acid oxidation, amino metabolism, distinct, indispensable roles in normal dysfunctional vasculature. also related endothelial cells. In present review, we brief overview how it regulates progression several diseases, atherosclerosis, systemic hypertension, diabetes, pulmonary calcification, aneurysms, effect risk factors disease (aging, cigarette smoking, excessive alcohol drinking) on VSMC clarify role key pathological process.

Язык: Английский

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Biomarkers of aging

Science China Life Sciences, Год журнала: 2023, Номер 66(5), С. 893 - 1066

Опубликована: Апрель 11, 2023

Язык: Английский

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miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases

Ageing Research Reviews, Год журнала: 2021, Номер 70, С. 101374 - 101374

Опубликована: Май 31, 2021

Язык: Английский

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Deep neural network-estimated electrocardiographic age as a mortality predictor

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Авг. 25, 2021

Abstract The electrocardiogram (ECG) is the most commonly used exam for evaluation of cardiovascular diseases. Here we propose that age predicted by artificial intelligence (AI) from raw ECG (ECG-age) can be a measure health. A deep neural network trained to predict patient’s 12-lead in CODE study cohort ( n = 1,558,415 patients). On 15% hold-out split, patients with ECG-age more than 8 years greater chronological have higher mortality rate (hazard ratio (HR) 1.79, p < 0.001), whereas those smaller, lower (HR 0.78, 0.001). Similar results are obtained external cohorts ELSA-Brasil 14,236) and SaMi-Trop 1,631). Moreover, even apparent normal ECGs, gap remains statistically significant risk predictor. These show AI-enabled analysis add prognostic information.

Язык: Английский

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Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 13, 2023

Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as capacity preserve and/or rapidly restore functions that promote disease resistance (immunocompetence) and control inflammation infectious diseases well other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics quantify balance between (i) CD8 + CD4 T-cell (ii) gene expression signatures tracking longevity-associated immunocompetence mortality-associated inflammation. Profiles ~48,500 individuals collectively indicate some persons resist degradation both during aging when challenged varied stressors. With resistance, preservation tracked a lower risk HIV acquisition, AIDS development, symptomatic influenza infection, recurrent skin cancer; survival COVID-19 sepsis; (iii) longevity. potentially reversible by decreasing Overall, show trait observed across age spectrum, more common females, aligned specific immunocompetence-inflammation linked favorable immunity-dependent health outcomes. mechanisms have utility biomarkers for measuring improving

Язык: Английский

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Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study

European Heart Journal, Год журнала: 2023, Номер 44(29), С. 2698 - 2709

Опубликована: Май 31, 2023

Abstract Aims Epigenetic age is emerging as a personalized and accurate predictor of biological age. The aim this article to assess the association subclinical atherosclerosis with accelerated epigenetic investigate underlying mechanisms mediating association. Methods results Whole blood methylomics, transcriptomics, plasma proteomics were obtained for 391 participants Progression Early Subclinical Atherosclerosis study. was calculated from methylomics data each participant. Its divergence chronological termed acceleration. burden estimated by multi-territory 2D/3D vascular ultrasound coronary artery calcification. In healthy individuals, presence, extension, progression associated significant acceleration Grim age, health lifespan, regardless traditional cardiovascular risk factors. Individuals an characterized increased systemic inflammation score low-grade, chronic inflammation. Mediation analysis using transcriptomics revealed key pro-inflammatory pathways (IL6, Inflammasome, IL10) genes (IL1B, OSM, TLR5, CD14) between Conclusion in middle-aged asymptomatic individuals are suggests role association, reinforcing relevance interventions on prevent disease.

Язык: Английский

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Impact of Aging on Cardiovascular Diseases

JACC Asia, Год журнала: 2024, Номер 4(5), С. 345 - 358

Опубликована: Апрель 8, 2024

Cardiovascular disease (CVD) has increasing challenges for human health with an increasingly aging population worldwide, imposing a significant obstacle to the goal of healthy aging. Rapid advancements in our understanding biological process have shed new light on some important insights aging-related diseases. Although numerous reviews delved into mechanisms through which affects CVD and age-related diseases, most these relied heavily research related cellular molecular processes often observed from animal experiments. Few provided that connect hypotheses regarding patterns chronological impacts populations. The purpose this review is highlight major questions studies provide perspectives context real-world multidimensional information potential insights.

Язык: Английский

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Very High Coronary Artery Calcium (≥1000) and Association With Cardiovascular Disease Events, Non–Cardiovascular Disease Outcomes, and Mortality

Circulation, Год журнала: 2021, Номер 143(16), С. 1571 - 1583

Опубликована: Март 2, 2021

There are limited data on the unique cardiovascular disease (CVD), non-CVD, and mortality risks of primary prevention individuals with very high coronary artery calcium (CAC; ≥1000), especially compared rates observed in secondary populations. Our study population consisted 6814 ethnically diverse 45 to 84 years age who were free known CVD from MESA (Multi-Ethnic Study Atherosclerosis), a prospective, observational, community-based cohort. Mean follow-up time was 13.6±4.4 years. Hazard ratios CAC ≥1000 both 0 400 999 for CVD, outcomes use Cox proportional hazards regression adjusted age, sex, traditional risk factors. Using sex-adjusted logarithmic model, we calculated event as function them those placebo group stable patients FOURIER clinical trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition Subjects Elevated Risk). Compared 999, (n=257) had greater mean number vessels (3.4±0.5), total area (586.5±275.2 mm2), similar density, more extensive extracoronary calcification. After full adjustment, demonstrated 4.71- (3.63-6.11), 7.57- (5.50-10.42), 4.86-(3.32-7.11), 1.94-fold (1.57-2.41) increased all events, heart hard all-cause mortality, respectively, 1.65- (1.25-2.16), 1.66- (1.22-2.25), 1.51- (1.03-2.23), 1.34-fold (1.05-1.71) 999. increasing CAC, hazard types, no apparent upper threshold. associated 1.95- 1.43-fold (1.12-1.83) first non-CVD respectively. 1000 corresponded an annualized 3-point major adverse rate 3.4 per 100 person-years, that (3.3) higher than lower-risk subgroups. Individuals (≥1000) at substantially outcomes, lower treated population. Future guidelines should consider less distinct stratification algorithm between guiding aggressive preventive pharmacotherapy.

Язык: Английский

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