Cardiovascular Diagnosis and Therapy,
Год журнала:
2024,
Номер
14(5), С. 771 - 787
Опубликована: Окт. 1, 2024
Numerous
studies
have
documented
the
effects
of
daytime
napping,
sleep
duration,
and
depression
on
cardiovascular
diseases
(CVDs).
However,
evidence
has
been
gleaned
from
observational
that
might
be
riddled
with
confounding
variables
possibility
reverse
causation
bias.
Therefore,
present
study
employed
a
Mendelian
randomization
(MR)
methodology
to
meticulously
explore
relationships
between
depression,
risk
profiles
CVDs.
CA A Cancer Journal for Clinicians,
Год журнала:
2023,
Номер
74(1), С. 84 - 114
Опубликована: Ноя. 1, 2023
Abstract
Current
US
lung
cancer
screening
recommendations
limit
eligibility
to
adults
with
a
pack‐year
(PY)
history
of
≥20
years
and
the
first
15
since
quit
(YSQ).
The
authors
conducted
systematic
review
better
understand
incidence,
risk
mortality
among
otherwise
eligible
individuals
in
this
population
beyond
YSQ.
PubMed
Scopus
databases
were
searched
through
February
14,
2023,
relevant
articles
by
hand.
Included
studies
examined
relationship
between
both
≥20‐PY
≥15
YSQ
diagnosis,
mortality,
ineligibility.
One
investigator
abstracted
data
second
confirmed.
Two
investigators
independently
assessed
study
quality
certainty
evidence
(COE)
resolved
discordance
consensus.
From
2636
titles,
22
26
included.
Three
provided
low
COE
elevated
incidence
YSQ,
as
compared
people
who
never
smoked,
six
moderate
that
diagnosis
after
declines
gradually,
but
no
clinically
significant
difference
just
before
Studies
examining
cancer‐related
disparities
suggest
outcomes
similar
African
American/Black
White
participants;
increasing
would
expand
for
individuals,
significantly
larger
proportion
individuals.
observed
not
only
persists
that,
may
remain
2
or
3
decades.
Future
research
nationally
representative
samples
consistent
reporting
across
is
needed,
are
from
which
examine
effects
on
health
different
populations.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(11), С. 9539 - 9539
Опубликована: Май 31, 2023
Lung
cancer
is
the
leading
cause
of
cancer-related
deaths
due
to
its
high
incidence,
late
diagnosis,
and
limited
success
in
clinical
treatment.
Prevention
therefore
critical
help
improve
lung
management.
Although
tobacco
control
cessation
are
effective
strategies
for
prevention,
numbers
current
former
smokers
USA
globally
not
expected
decrease
significantly
near
future.
Chemoprevention
interception
needed
high-risk
individuals
reduce
their
risk
or
delay
development.
This
article
will
review
epidemiological
data,
pre-clinical
animal
data
that
support
potential
kava
reducing
human
via
holistic
polypharmacological
effects.
To
facilitate
future
translation,
advanced
knowledge
with
respect
mechanisms
action
development
mechanism-based
non-invasive
biomarkers
addition
safety
efficacy
more
clinically
relevant
models.
Mayo Clinic Proceedings,
Год журнала:
2024,
Номер
99(3), С. 387 - 399
Опубликована: Фев. 6, 2024
ObjectiveTo
investigate
whether
joint
risk
factor
control
could
reduce
the
excess
of
cardiovascular
disease
(CVD)
in
patients
with
hypertension.Patients
and
MethodsA
total
75,293
diagnosed
hypertension
from
UK
Biobank
study
were
included,
matched
256,619
nonhypertensive
controls,
followed
up
until
May
31,
2021.
Seven
factors
measured
to
define
control,
including
blood
pressure,
body
mass
index,
low-density
lipoprotein
cholesterol,
hemoglobin
A1c,
albuminuria,
smoking,
physical
activity.ResultsAmong
hypertensive
patients,
14%
24%
lower
risks
CVD
outcomes
associated
each
additional
control.
In
Cox
proportional
hazards
models,
adjusted
hazard
ratios
for
6
or
more
controls
compared
having
2
less
0.49
(95%
CI,
0.45
0.55)
CVD,
0.51
0.57)
coronary
heart
disease,
0.48
0.38
0.60)
stroke,
0.34
0.26
0.44)
mortality.
The
diminished
nonsignificant
even
if
achieving
controls.
Men
experienced
stronger
protective
associations
on
than
women
(P<.001
interaction).ConclusionThe
is
a
high
degree
may
considerably
attenuate
among
hypertension.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Май 27, 2025
Heart
Failure
with
Preserved
Ejection
Fraction
(HFpEF)
is
a
heterogeneous
syndrome
characterized
by
systemic
multiorgan
dysfunction,
and
exercise
rehabilitation
has
emerged
as
promising
non-pharmacological
intervention.
This
review
synthesizes
current
evidence
on
the
pathophysiological
mechanisms
underlying
intolerance
in
HFpEF
evaluates
therapeutic
efficacy
of
exercise-based
interventions.
Key
include
myocardial
stiffness
due
to
chronic
inflammation,
coronary
microvascular
skeletal
muscle
mitochondrial
impairment,
endothelial
dysfunction.
Clinical
studies
indicate
that
tailored
regimens
(e.g.,
combined
aerobic-resistance
training)
improve
peak
oxygen
consumption,
6
min
walking
distance,
quality
life
through
multi-organ
adaptations:
enhanced
cardiac
output
reserve,
metabolic
remodeling,
reduced
inflammation.
However,
challenges
persist
optimizing
prescriptions
for
phenotypically
diverse
subpopulations
obese,
elderly
frail).
Future
research
must
prioritize
phenotype-specific
protocols,
validate
long-term
outcomes
(mortality,
hospitalization),
integrate
biomarkers
H
2
FPEF
score)
digital
health
technologies
advance
precision
strategies.
highlights
imperative
mechanistic
insights
guide
clinical
translation
management.
