IJC Heart & Vasculature, Год журнала: 2024, Номер 51, С. 101393 - 101393
Опубликована: Март 29, 2024
Язык: Английский
European Journal of Preventive Cardiology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 13, 2024
Abstract Aims The prediction of future trends in cardiovascular disease (CVD) mortality and their risk factors can assist policy-makers healthcare planning. This study aims to project geospatial CVDs underlying from 2025 2050. Methods results Using historical data on disability-adjusted life years (DALYs) the Global Burden Disease (GBD) 2019 study, encompassing period 1990 2019, Poisson regression was performed model DALYs associated with CVD its Subgroup analysis based GBD super-regions. Between 2050, a 90.0% increase prevalence, 73.4% crude mortality, 54.7% are projected, an expected 35.6 million deaths 2050 (from 20.5 2025). However, age-standardized prevalence will be relatively constant (−3.6%), decreasing (−30.5%) (−29.6%). In ischaemic heart remain leading cause (20 deaths) while high systolic blood pressure main factor driving (18.9 deaths). Central Europe, Eastern Asia super-region is set incur highest rate (305 per 100 000 population). Conclusion coming decades, global suggests that net effect summative preventative efforts likely continue unchanged. fall reflects improvement medical care following diagnosis. systems expect rapid rise driven by ageing populace. continued burden largely attributed atherosclerotic diseases. Registration Not applicable.
Язык: Английский
Процитировано
43
European Heart Journal, Год журнала: 2024, Номер 45(20), С. 1783 - 1800
Опубликована: Апрель 12, 2024
Clinical risk scores based on traditional factors of atherosclerosis correlate imprecisely to an individual's complex pathophysiological predisposition and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners techniques coronary angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification characterization. The CCTA quantifying stenosis has been validated in numerous multicentre studies shown consistent incremental prognostic value MACE over clinical spectrum different populations. Serial advanced our understanding vascular biology disease progression. direct visualization potential be used synergistically with indirect markers significantly improve prevention MACE, pending large-scale randomized evaluation.
Язык: Английский
Процитировано
25
Diabetes Research and Clinical Practice, Год журнала: 2024, Номер 211, С. 111652 - 111652
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
11
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Июль 23, 2024
Abstract Background A significant percentage of patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRFs) are being identified. Nonetheless, the prognostic influence TyG index on adverse events in this type patient remains unexplored. The aim study was to assess value among ACS SMuRFs for predicting outcomes. Methods This involved 1140 consecutive who were diagnosed at Beijing Anzhen Hospital between May 2018 and December 2020 underwent angiography. Each followed up a period 35 66 months after discharge. objective examine major cardiac cerebrovascular (MACCE), which included all-cause mortality, non-fatal myocardial infarction, ischemic stroke, as well ischemia-driven revascularization. Results During median follow-up 48.3 months, 220 (19.3%) MACCE occurred. average age participants 59.55 ± 10.98 years, 8.67 0.53. In fully adjusted model, when considering either continuous/categorical variable, associations outcomes observed. Specifically, each 1 deviation increase within highest group, there hazard ratio (HR) 1.245 (95% confidence interval CI 1.030, 1.504) 1.303 1.026, 1.653) revascularization (both P < 0.05), analyzed continuous variable. Similarly, examined categorical HR CI) group 1.693 1.051, 2.727) (P 0.05) while 1.855 0.998, 3.449) = 0.051). Additionally, found be associated poor prognosis subgroup. Conclusion is correlated SMuRFs, suggesting that it may an independent predictive factor these individuals.
Язык: Английский
Процитировано
7
JACC Asia, Год журнала: 2024, Номер 4(7), С. 507 - 516
Опубликована: Май 28, 2024
The lack of standard modifiable cardiovascular risk factors (SMuRFs), including hypertension, diabetes, dyslipidemia, and smoking, is reportedly associated with poor outcomes in acute myocardial infarction (AMI). Among patients no SMuRFs, cancer chronic systemic inflammatory diseases (CSIDs) may be major etiologies AMI.
Язык: Английский
Процитировано
6
Journal of the American College of Cardiology, Год журнала: 2024, Номер 83(23), С. 2308 - 2323
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
4
Cardiovascular Intervention and Therapeutics, Год журнала: 2024, Номер unknown
Опубликована: Июнь 17, 2024
Abstract Standard modifiable cardiovascular risk factors (SMuRFs), such as hypertension, diabetes, dyslipidemia, and current smoking, are associated with the development of atherosclerotic diseases including acute myocardial infarction (MI). Thus, therapeutic approaches against SMuRFs important primary secondary prevention diseases. In patients MI, however, prognosis is counterintuitively poor when lacking. The growing evidence has explored prevalence, pathophysiology, SMuRF-less in MI suggested potential underlying mechanisms. This review article summarizes clinical relevance lack MI.
Язык: Английский
Процитировано
4
Genes, Год журнала: 2025, Номер 16(1), С. 98 - 98
Опубликована: Янв. 18, 2025
Objective: Coronary atherosclerosis (CAD) is characterized by arterial intima lipid deposition, chronic inflammation, and fibrous tissue proliferation, leading to wall thickening lumen narrowing. As the primary cause of coronary heart disease acute syndrome, CAD significantly impacts global health. Recent genetic studies have demonstrated CAD’s polygenic multifactorial nature, providing molecular insights for early diagnosis risk assessment. This review analyzes recent advances in CAD-related markers evaluates their diagnostic potential, focusing on applications stratification within precision medicine. Methods: We conducted a systematic genomic from PubMed Web Science databases, analyzing findings genome-wide association (GWASs), gene sequencing, transcriptomics, epigenomics research. Results: GWASs sequencing identified key variations associated with CAD, including JCAD/KIAA1462, GUCY1A3, PCSK9, SORT1, which regulate metabolism, vascular function. Transcriptomic epigenomic analyses revealed disease-specific expression patterns, DNA methylation signatures, regulatory non-coding RNAs (miRNAs lncRNAs), new approaches detection. Conclusions: While marker research has advanced significantly, clinical implementation faces challenges dynamics, lack standardization, integration conventional diagnostics. Future should prioritize developing standardized guidelines, conducting large-scale prospective studies, enhancing multi-omics data advance diagnostics ultimately improving patient outcomes through
Язык: Английский
Процитировано
0
Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 22, 2025
Abstract Background The ABO blood group system has shown an association with cardiovascular disease. susceptibility to CVD is proposed be partly mediated by dyslipidaemia in non-O individuals. Previous studies are scarce for the RhD group, but we recently showed that − young individuals associated subclinical atherosclerosis. Hence, sought examine whether groups and factor dyslipidaemia. Methods All participants were part of VIPVIZA study, including 3532 available plasma lipid levels. Lipids assessed as total, LDL, HDL, remnant, non-HDL cholesterol triglycerides. Information about was retrieved linking SCANDAT-3 database, where 85% registered. Results For groups, no significant differences levels between O seen. In 40-year-old males, compared + had higher cholesterol, LDL remnant ratios geometric means 1.21 (CI95% 1.03; 1.43), 1.20 (1.02; 1.41) 1.38 (1.00; 1.92), respectively. No depending on seen women or older age groups. Conclusion Our study indicates younger men have increased non-HDL, Thus, not ABO, seems may act a future possible risk marker Graphical
Язык: Английский
Процитировано
0
Vascular Health and Risk Management, Год журнала: 2025, Номер Volume 21, С. 39 - 50
Опубликована: Фев. 1, 2025
Background: A growing number of individuals develop atherosclerotic cardiovascular disease (ASCVD) despite the absence standard modifiable risk factors (hypertension, diabetes, dyslipidemia, and cigarette smoking) (SMuRF-less patients). Prevalence SMuRF-less patients in Middle East has not been studied. This study investigates prevalence, clinical profiles outcomes compared with those who have SMuRFs. Methods: We analyzed data from 6 published registries Jordan study, including baseline demographic features, factors, comorbid diseases, utilization secondary prevention pharmacotherapy one year outcome patients, 1– 2 SMuRFs 3– 4 Results. total f 5540 ASCVD were enrolled. Mean age was 57.5 ± 11.6 years, 1333 (24.1%) women. Of whole group, 214 (3.9%) SMuRF-less, 3014 (54.4%) had 2312 (41.7%) Compared groups, group younger, more likely to be men, lower prevalence obesity, physical inactivity, metabolic syndrome, heart failure chronic kidney disease. less receive medications (antiplatelet agents, statins, renin angiotensin blockers beta blockers); all p < 0.001. One survival significantly than that groups (97.7% vs.98.4% vs.98.3%, respectively, = 0.01). Multivariate analysis showed young age, preventive associated better outcome. Conclusion: In this cohort ME ASCVD, nearly four 100 SMuRF-less. rate is reported by most studies, mainly due high disease, received higher mortality Clinical Trials: The registered ClinicalTrials.gov, unique identifier NCT06199869. Keywords: Eastern
Язык: Английский
Процитировано
0