2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association

Stroke, Год журнала: 2024, Номер 55(12)

Опубликована: Окт. 21, 2024

The "2024 Guideline for the Primary Prevention of Stroke" replaces 2014 "Guidelines Stroke." This updated guideline is intended to be a resource clinicians use guide various prevention strategies individuals with no history stroke.

Язык: Английский

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Do the associations of daily steps with mortality and incident cardiovascular disease differ by sedentary time levels? A device-based cohort study

British Journal of Sports Medicine, Год журнала: 2024, Номер 58(5), С. 261 - 268

Опубликована: Март 1, 2024

Objectives This study aims to examine the associations of daily step count with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels determine if minimal optimal number steps is modified high time. Methods Using data from UK Biobank, this was a prospective dose–response analysis total across low (<10.5 hours/day) (≥10.5 (as defined inflection point adjusted absolute risk two outcomes). Mortality CVD ascertained through 31 October 2021. Results Among 72 174 participants (age=61.1±7.8 years), 1633 deaths 6190 events occurred over 6.9 (±0.8) years follow-up. Compared referent 2200 steps/day (5th percentile), dose (nadir curve) for ranged between 9000 10 500 (HR (95% CI)=0.61 (0.51 0.73)) (0.69 (0.52 0.92)) For CVD, there subtle gradient association level lowest observed at approximately 9700 (0.79 (0.72 0.86)) (0.71 (0.61 0.83)) The (steps/day associated 50% dose) 4000 4500 groups CVD. Conclusions Any amount above lower risk, Accruing 9000–10 independent roughly equivalent steps/day, compared

Язык: Английский

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Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta‐Analyses

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2025, Номер 16(2)

Опубликована: Март 5, 2025

Numerous studies support the association of exercise training, physical activity (PA) and sedentary behaviour (SB) with both mortality morbidity outcomes. The results across have been inconsistent, no umbrella reviews yet conducted on this topic. We an review meta-analyses observational by screening articles in PubMed/MEDLINE, EMBASE Web Science databases from inception to 30 April 2024. Quality appraisal each included meta-analysis was done using AMSTAR 2 tool, evidence certainty evaluated based statistical significance, study size, heterogeneity, small-study effects, prediction intervals (PI) potential biases. Frothy-eight were (AMSTAR ratings: high 25, moderate 10, low critically 11). No highly suggestive or convincing. Suggestive linked any PA SB lower higher risks all-cause, cardiovascular cancer mortality. indicated a significant between self-reported device-measured total (equivalent odds ratio [eOR] 0.78 [0.70-0.86] eHR = 0.50 [0.38-0.65], respectively), leisure time (eHR 0.73 [0.66-0.80]), daily steps 0.44 [0.35-0.56]) aerobic plus resistance training 0.60 [0.56-0.64]) all-cause Weak supported links 1.3 [1.22-1.38] 2.16 [1.09-4.28], respectively). noted for 0.74 [0.69-0.80]) 0.82 [0.81-0.84]) also found 0.87 [0.83-0.91]) Associations running all causes, diseases (CVD) did not reach significance nor skeletal muscle mass Meta-regression analyses showed that reduces risk, age reducing protective effects against CVD combined (aerobic resistance) most effectively Converging supports are associated rates More high-quality prospective needed better understanding associations TV-viewing health-related

Язык: Английский

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Lifestyle factors as determinants of atherosclerotic cardiovascular health

Atherosclerosis, Год журнала: 2024, Номер 395, С. 117577 - 117577

Опубликована: Май 10, 2024

A sedentary lifestyle, low levels of physical activity and fitness, poor dietary patterns, psychosocial stress are strongly associated with increased morbidity mortality from atherosclerotic cardiovascular disease (ASCVD). Conversely, engaging in regular activity, maintaining optimal fitness levels, adhering to a heart-healthy pattern, effectively managing body weight, ensuring adequate sleep, implementing stress-reduction strategies, addressing risk factors reduced ASCVD. This comprehensive review synthesizes current evidence large observational studies randomized controlled trials on lifestyle as determinants ASCVD health. It also briefly reviews mechanistic insights into how such shear stress, reactive oxygen species production, chronic inflammation, platelets coagulation activation, endothelial dysfunction, sympathetic hyperactivity contribute the initiation exacerbation factors. These include obesity, hyperglycemia, type 2 diabetes, hypertension, dyslipidemia, subsequently leading development progression atherosclerosis, ultimately resulting or acute events. To bridge translational gap between epidemiologic trial-based clinical practice, practical recommendations summarized facilitate translation scientific knowledge actionable interventions promote Acknowledged is evidence-based adoption within healthcare systems, which remains crucial objective advancing health at population level.

Язык: Английский

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Associations of “Weekend Warrior” Physical Activity With Incident Disease and Cardiometabolic Health

Circulation, Год журнала: 2024, Номер 150(16), С. 1236 - 1247

Опубликована: Сен. 26, 2024

BACKGROUND: Achievement of guideline-recommended levels physical activity (≥150 minutes moderate-to-vigorous per week) is associated with lower risk adverse cardiovascular events and represents an important public health priority. Although commonly follows a “weekend warrior” pattern, in which most concentrated 1 or 2 days rather than spread more evenly across the week (regular), effects pattern range incident diseases, including cardiometabolic conditions, are unknown. METHODS: We tested associations between incidence 678 conditions 89 573 participants (62±8 years age; 56% women) UK Biobank prospective cohort study who wore accelerometer for June 2013 December 2015. Models were adjusted multiple baseline clinical factors, P value thresholds corrected multiplicity. RESULTS: When compared to inactive (<150 activity/week), both weekend warrior (267 total associations; 264 [99%] disease risk; hazard ratio [HR] range, 0.35–0.89) regular (209 205 [98%] HR 0.41–0.88) broadly disease. The strongest observed such as hypertension (weekend warrior: HR, 0.77 [95% CI, 0.73–0.80]; =1.2×10 -27 ; regular: 0.72 0.68–0.77]; =4.5×10 -28 ), diabetes 0.57 0.51–0.62]; =3.9×10 -32 0.54 0.48–0.60]; =8.7×10 -26 obesity 0.55 0.50–0.60]; =2.4×10 -43 , 0.44 0.40–0.50]; =9.6×10 -47 sleep apnea 0.48–0.69]; =1.6×10 -9 0.49 0.39–0.62]; =7.4×10 -10 ). directly, there no differed significantly. Observations similar when was thresholded at sample median (≥230.4 activity/week). CONCLUSIONS: measured volumes consistent guideline recommendations >200 prominent on conditions. Associations appear whether throughout week.

Язык: Английский

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SGLT inhibitors for improving Healthspan and lifespan

Progress in Cardiovascular Diseases, Год журнала: 2023, Номер 81, С. 2 - 9

Опубликована: Окт. 17, 2023

Язык: Английский

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Economic Perspective of the Use of Wearables in Health Care: A Systematic Review

Mayo Clinic Proceedings Digital Health, Год журнала: 2024, Номер 2(3), С. 299 - 317

Опубликована: Май 14, 2024

The objective of this study is to explore the current state research concerning cost-effectiveness wearable health technologies, excluding hearing aids, owing extensive previous investigation. A systematic review was performed using PubMed, EMBASE/MEDLINE, Google Scholar, and Cumulated Index Nursing Allied Health Literature search studies evaluating devices in terms quality-adjusted life years incremental ratio. conducted on March 28, 2023, date publication did not limit search. yielded 10 eligible for inclusion. These studies, published between 2012 spanned various locations globally. used data from hypothetical cohorts, existing research, randomized controlled trials, meta-analyses. They covered a diverse range technologies applied different care settings, including respiratory rate monitors, pedometers, fall-prediction devices, hospital-acquired pressure injury prevention seizure detection heart insulin therapy sensors, cardioverter defibrillators. time horizons analyses ranged less than year lifetime. indicate that can increase be cost-effective potentially cost-saving. However, depends factors, such as type device, condition being addressed, specific perspective economic analysis, local cost payment structure, willingness-to-pay thresholds. use wearables promises improving outcomes resource allocation. more needed fully understand long-term benefits strengthen evidence base providers, policymakers, patients.

Язык: Английский

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Daily steps and all-cause mortality: An umbrella review and meta-analysis

Preventive Medicine, Год журнала: 2024, Номер 185, С. 108047 - 108047

Опубликована: Июнь 18, 2024

This study aimed to describe the variability in estimates of association daily steps and all-cause mortality systematic reviews with meta-analyses, identify factors potentially responsible for it, provide an updated estimate.

Язык: Английский

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Step Count: The Next Vital Sign

Journal of General Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

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Even a small dose of physical activity can be good medicine

Nature Medicine, Год журнала: 2025, Номер 31(2), С. 376 - 378

Опубликована: Янв. 6, 2025

Язык: Английский

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