Current Oncology Reports, Год журнала: 2024, Номер 26(11), С. 1431 - 1441
Опубликована: Сен. 24, 2024
Язык: Английский
Current Oncology Reports, Год журнала: 2024, Номер 26(11), С. 1431 - 1441
Опубликована: Сен. 24, 2024
Язык: Английский
Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11
Опубликована: Июль 1, 2024
Cardiovascular disease (CVD) represents the leading cause of mortality and disability all over world. Identifying new targeted therapeutic approaches has become a priority biomedical research to improve patient outcomes quality life. The RAS-RAF-MEK (mitogen-activated protein kinase kinase)-ERK (extracellular signal-regulated kinase) pathway is gaining growing interest as potential signaling cascade implicated in pathogenesis CVD. This pivotal regulating cellular processes like proliferation, growth, migration, differentiation, survival, which are vital maintaining cardiovascular homeostasis. In addition, ERK involved controlling angiogenesis, vascular tone, myocardial contractility, oxidative stress. Dysregulation this been linked cell dysfunction cardiac pathological remodeling, contribute onset progression Recent ongoing provided insights into interventions targeting RAS-RAF-MEK-ERK pathologies. Preclinical studies have demonstrated efficacy therapy with MEK inhibitors (MEKI) attenuating activation mitigating CVD animal models. article, we first describe how contributes preserving health. We then summarize current knowledge roles played by development disorders, including atherosclerosis, infarction, hypertrophy, heart failure, aortic aneurysm. finally report novel strategies for these CVDs encompassing MEKI discuss advantages, challenges, future developments therapeutics.
Язык: Английский
Процитировано
5Current Oncology Reports, Год журнала: 2024, Номер 26(11), С. 1431 - 1441
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
1