International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11380 - 11380
Опубликована: Июль 12, 2023
Atopic
dermatitis
represents
a
complex
and
multidimensional
interaction
that
potential
fields
of
preventive
therapeutic
management.
In
addition
to
the
treatment
armamentarium
available
for
atopic
dermatitis,
novel
drugs
targeting
significant
molecular
pathways
in
biologics
small
molecules
are
also
being
developed
given
condition’s
pathophysiology.
While
most
patients
expecting
better
efficacy
long-term
control,
response
these
would
still
depend
on
numerous
factors
such
as
genotype,
diverse
environmental
triggers
microbiome-derived
signals,
and,
importantly,
dynamic
immune
responses.
This
review
article
highlights
challenges
recently
pharmacological
agents
based
pathogenesis
this
condition,
creating
specific
approach
toward
more
personalized
medicine.
Journal of Medicinal Chemistry,
Год журнала:
2021,
Номер
64(3), С. 1283 - 1345
Опубликована: Янв. 22, 2021
Great
successes
have
been
achieved
in
developing
small-molecule
kinase
inhibitors
as
anticancer
therapeutic
agents.
However,
deregulation
plays
essential
roles
not
only
cancer
but
also
almost
all
major
disease
areas.
Accumulating
evidence
has
revealed
that
kinases
are
promising
drug
targets
for
different
diseases,
including
cancer,
autoimmune
inflammatory
cardiovascular
central
nervous
system
disorders,
viral
infections,
and
malaria.
Indeed,
the
first
inhibitor
treatment
of
a
nononcologic
was
approved
2011
by
U.S.
FDA.
To
date,
10
such
approved,
more
clinical
trials
applications
other
than
cancer.
This
Perspective
discusses
number
their
diseases
fields.
The
opportunities
challenges
highlighted.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(3), С. 699 - 699
Опубликована: Янв. 21, 2020
During
the
last
decades,
high-throughput
assessment
of
gene
expression
in
patient
tissues
using
microarray
technology
or
RNA-Seq
took
center
stage
clinical
research.
Insights
into
diversity
and
frequency
transcripts
healthy
diseased
conditions
provide
valuable
information
on
cellular
status
respective
tissues.
Growing
with
technique,
bioinformatic
analysis
toolkit
reveals
biologically
relevant
pathways
which
assist
understanding
basic
pathophysiological
mechanisms.
Conventional
classification
systems
inflammatory
skin
diseases
rely
descriptive
assessments
by
pathologists.
In
contrast
to
this,
molecular
profiling
may
uncover
previously
unknown
disease
classifying
features.
Thereby,
treatments
prognostics
patients
be
improved.
Furthermore,
models
research
comparison
human
can
directly
validated.
The
aim
this
article
is
not
only
reader
opportunities
these
techniques,
but
outline
potential
pitfalls
technical
limitations
as
well.
Major
published
findings
are
briefly
discussed
a
broad
overview
current
transcriptomics
diseases.
Allergologie select,
Год журнала:
2021,
Номер
5(01), С. 293 - 304
Опубликована: Янв. 1, 2021
The
JAK-STAT
pathway
is
involved
in
the
signaling
of
multiple
cytokines
driving
cutaneous
inflammation
atopic
dermatitis
(AD).Janus
kinase
(JAK)
inhibitors
target
individual
receptor-associated
kinases,
thereby
preventing
mediation
inflammatory
signals.Several
JAK
with
varying
mechanism
action,
potency,
and
safety
represent
potential
therapeutic
options
for
AD
both
topical
systemic
application.The
JAK1/2
selective
inhibitor
baricitinib
was
first
substance
from
this
class
drugs
approved
by
EMA
oral
treatment
AD.The
clinical
development
program
JAK1
upadacitinib
abrocitinib
finalized
positive
results
PAN-JAK
delgocitinib
being
(in
Japan).This
review
article
covers
rising
data
on
investigational
context
AD.
Cells,
Год журнала:
2021,
Номер
10(6), С. 1392 - 1392
Опубликована: Июнь 4, 2021
Atopic
dermatitis
(AD)
is
one
of
the
most
prevalent
inflammatory
disease
among
non-fatal
skin
diseases,
affecting
up
to
fifth
population
in
developed
countries.
AD
characterized
by
recurrent
pruritic
and
localized
eczema
with
seasonal
fluctuations.
initializes
phenomenon
atopic
march,
during
which
infant
patients
are
predisposed
progressive
secondary
allergies
such
as
allergic
rhinitis,
asthma,
food
allergies.
The
pathophysiology
complex;
onset
caused
several
factors,
including
strong
genetic
predisposition,
disrupted
epidermal
barrier,
immune
dysregulation.
was
initially
defects
innate
system
a
vigorous
skewed
adaptive
Th2
response
environmental
agents;
there
compelling
evidences
that
disorder
involves
multiple
pathways.
Symptomatic
palliative
treatment
only
strategy
manage
restore
integrity.
Researchers
trying
more
precisely
define
contribution
different
genotypes
elucidate
role
various
axes.
In
this
review,
we
have
summarized
current
knowledge
about
roles
responsive
cells
AD.
addition,
novel
strategies
for
management
comprehensively
described,
some
ongoing
clinical
trials
promising
therapeutic
agents.
This
information
will
provide
an
asset
towards
identifying
personalized
targets
better
outcomes.
Allergy,
Год журнала:
2021,
Номер
77(2), С. 416 - 441
Опубликована: Июль 13, 2021
Food
allergy
(FA)
is
now
one
of
the
most
common
chronic
diseases
childhood
often
lasting
throughout
life
and
leading
to
significant
worldwide
healthcare
burden.
The
precise
mechanisms
responsible
for
development
this
inflammatory
condition
are
largely
unknown;
however,
a
multifactorial
aetiology
involving
both
environmental
genetic
contributions
well
accepted.
A
understanding
pathogenesis
FA
an
essential
first
step
developing
comprehensive
prevention
strategies
that
could
mitigate
epidemic.
As
it
frequently
preceded
by
atopic
dermatitis
can
be
prevented
early
antigen
introduction,
likely
facilitated
improper
initial
presentation
immune
system.
Primary
oral
exposure
antigens
allowing
via
well-developed
mucosal
system,
rather
than
through
disrupted
skin
epidermal
barrier,
prevent
FA.
In
review,
we
present
data
supporting
necessity
(1)
intact
barrier
epicutaneous
presentation,
(2)
presence
specific
commensal
bacteria
maintain
system
(3)
maternal/infant
diet
diversity,
including
vitamins
minerals,
appropriately
timed
allergenic
food
introduction
