Cellular Signalling, Год журнала: 2023, Номер 113, С. 110964 - 110964
Опубликована: Ноя. 11, 2023
Язык: Английский
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Июль 28, 2023
This study aims to assess the associations of complete blood cell count (CBC)-derived inflammatory biomarkers with prevalence asthma and mortality.Data was collected from 1999-2018 National Health Nutrition Examination Survey (NHANES). Mortality identified using Death Index until December 31, 2019. The analyzed relationship between CBC-derived biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), systemic response index (SIRI), immune-inflammation (SII), multiple logistic regressions. To significance in predicting all-cause respiratory disease mortality patients, Cox proportional regressions random survival forest (RSF) analysis were utilized.A total 48,305 participants included, a mean age 47.27 ± 0.18 years 49.44% male. Among them, 6,403 had asthma, 13.28%. deaths at median follow-up 8.2 (4.5, 12.8) 929 137 respectively. After adjusting for confounders, found be positively associated NLR, PLR, MLR, SIRI SII. Compared lowest quartile, highest quartile NLR (HR=1.765 [1.378-2.262]), MLR (HR=1.717 [1.316-2.241]), (HR=1.796 [1.353-2.383]) SII (HR=1.432 [1.141-1.797]) an increased risk mortality. These more pronounced patients. RSF showed that predictive value adults asthma. sensitivity demonstrated stability our results.The findings suggest are higher
Язык: Английский
Процитировано
49
Chemico-Biological Interactions, Год журнала: 2024, Номер 394, С. 111002 - 111002
Опубликована: Апрель 9, 2024
Lung inflammatory disorders are a major global health burden, impacting millions of people and raising rates morbidity death across many demographic groups. An industrial chemical common environmental contaminant, formaldehyde (FA) presents serious concerns to the respiratory system, including onset aggravation lung disorders. Epidemiological studies have shown significant associations between FA exposure levels incidence severity several diseases. causes inflammation in tract via immunological activation, oxidative stress, airway remodelling, aggravating pre-existing pulmonary compromising function. Additionally, functions as sensitizer, causing allergic responses hypersensitivity pneumonitis sensitive people. Understanding complicated processes behind formaldehyde-induced is critical for directing targeted strategies aimed at minimizing exposures alleviating burden formaldehyde-related illnesses on health. This abstract explores intricate relationship diseases, asthma, bronchitis, inflammation, injury fibrosis.
Язык: Английский
Процитировано
27
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Июль 16, 2024
Preclinical evidence has firmly established a bidirectional interaction among the lung, gut, and gut microbiome. There are many complex communication pathways between lung intestine, which affect each other's balance. Some metabolites produced by intestinal microorganisms, immune cells, factors enter tissue through blood circulation participate in function. Altered gut-lung-microbiome interactions have been identified rodent models humans of several diseases such as pulmonary fibrosis, chronic obstructive disease, cancer, asthma, etc. Emerging suggests that microbial therapies can prevent treat respiratory diseases, but it is unclear whether this association simple correlation with pathological mechanisms disease or result causation. In review, we summarize critical link microbiota well influence mechanism on discuss role interventions prebiotics fecal bacteria transplantation diseases. To provide reference for rational design large-scale clinical studies, direct application therapy to respiratory-related reduce incidence severity accompanying complications.
Язык: Английский
Процитировано
10
iMeta, Год журнала: 2025, Номер 4(1)
Опубликована: Фев. 1, 2025
Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.
Язык: Английский
Процитировано
2
BMC Pulmonary Medicine, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 31, 2025
Asthma and atopic dermatitis (AD) represent significant global health challenges in children. This study aimed to investigate trends incidence, prevalence, disability-adjusted life years (DALYs) for childhood asthma AD from 1990 2021. The utilized information the Global Burden of Disease (GBD), Injuries, Risk Factors Study sample size this consisted children with or between ages 0 14. From 1990–2021, we calculated AD's age-standardized DALYs by area, age, sex, socio-demographic index. In 2021, prevalence reached 95.7 million cases (age-standardized rate: 4,758 per 100,000), Low SDI region recording 25.4 cases. For AD, was 72.4 3,600 predominantly Middle regions (19.7 cases). Between incidence rates decreased both conditions. Geographic variations were notable: High-income North America showed highest while Western Europe led prevalence. burden asthma-related declined 6.9 4.6 regional disparities. Despite decreasing rates, continue pose substantial burdens globally, marked across socioeconomic strata. These findings emphasize need targeted, region-specific interventions.
Язык: Английский
Процитировано
1
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1079 - 1079
Опубликована: Фев. 8, 2025
Biologic therapies have revolutionized the treatment of severe allergic diseases, including asthma, atopic dermatitis (AD), chronic spontaneous urticaria (CSU), rhinosinusitis with nasal polyps (CRSwNP), eosinophilic gastrointestinal diseases (EGIDs), and rhinitis (AR). These molecularly targeted agents provide significant benefits for patients unresponsive to conventional treatments by addressing underlying immune mechanisms, particularly type 2 inflammation driven cytokines such as IL-4, IL-5, IL-13. Recent advancements include biologics targeting alarmins like thymic stromal lymphopoietin (TSLP) IL-33, which may address both non-type inflammation, broadening their therapeutic scope. Despite effectiveness, remain expensive, posing socioeconomic challenges, there are concerns regarding long-term safety inter-individual variability in responses. Promising innovations bispecific antibodies ultra-long-acting under investigation, alongside digital health tools remote biomarker monitoring AI-driven decision support systems, aim enhance personalized care. However, disparities access, underserved populations, underscore need policy reforms affordable biosimilars. This review synthesizes recent findings emerging trends, highlighting evolving role transforming disease management offering insights into future research directions.
Язык: Английский
Процитировано
1
Frontiers in Genetics, Год журнала: 2025, Номер 16
Опубликована: Март 5, 2025
NEAT1, a long non-coding RNA (lncRNA), is involved in assembling nuclear paraspeckles that have been found to impact various immune-related diseases, such as autoimmune allergic cancer immunity, sepsis, etc. In lncRNA-NEAT1 affects the activation, proliferation, and differentiation process of immune cells by interacting with transcription factors miRNA (MicroRNA) regulate an expression level genes. It can also apoptosis autophagy processes regulating inflammatory responses, apoptosis-related proteins, or autophagy-related genes, thereby development diseases. recent years, large number researchers abnormal has great on onset progression innate immunity after viral infection humoral T lymphocytes. this paper, specific mechanism action function different diseases are sorted out analyzed, furnish theoretical foundation for study cells.
Язык: Английский
Процитировано
1
World Allergy Organization Journal, Год журнала: 2023, Номер 16(10), С. 100825 - 100825
Опубликована: Окт. 1, 2023
Язык: Английский
Процитировано
20
Allergy, Год журнала: 2024, Номер unknown
Опубликована: Окт. 27, 2024
Abstract Background The role of lung group 2 innate lymphoid cell (ILC2) activation in allergic asthma is increasingly established. However, the regulatory mechanisms underlying hypoxia‐inducible factor‐1α (HIF‐1α)‐mediated glycolysis ILC2‐mediated airway inflammation remain unclear. Objective To investigate HIF‐1α/glycolysis axis inflammation. Methods Glycolysis and HIF‐1α inhibitors were used to identify their effect on function glucose metabolism mouse human ILC2s vivo vitro. Blocking mice under interleukin‐33 (IL‐33) stimulation performed test ILC2 responses. Conditional HIF‐1α‐deficient confirm specific ILC2‐driven models. Transcriptomic, metabolic, chromatin immunoprecipitation analyses elucidate mechanism. Results involved crucial Single‐cell sequencing data analysis qPCR confirmation revealed a significant upregulation glycolysis‐related genes, particularly HIF‐1α, murine after IL‐33 intranasal administration or injection. Treatment with inhibitor 2‐deoxy‐D‐glucose (2‐DG) 2‐methoxyestradiol (2‐ME) abrogated by suppressing function. showed reduced response induced upon house dust mite (HDM) stimulation. Transcriptome metabolic significantly impaired conditional knockout compared that littermate controls. Chromatin results confirmed transcriptional downregulation genes HIF‐1α‐knockout 2‐DG‐treated mice. Furthermore, correlated downregulated patients asthma. Conclusion critical for controlling responses has potential immunotherapeutic value
Язык: Английский
Процитировано
9
Laboratory Investigation, Год журнала: 2024, Номер 104(5), С. 102044 - 102044
Опубликована: Март 5, 2024
Язык: Английский
Процитировано
8