Environmental Toxicology,
Год журнала:
2024,
Номер
39(5), С. 3188 - 3197
Опубликована: Фев. 14, 2024
Abstract
Yin
chai
hu
(Radix
Stellariae)
is
a
root
medicine
that
frequently
used
in
Chinese
traditional
to
treat
fever
and
malnutrition.
In
modern
medicine,
it
has
been
discovered
have
anti‐inflammatory,
anti‐allergic,
anticancer
properties.
previous
study,
we
were
able
extract
lipids
from
Stellariae
Radix
using
supercritical
CO
2
extraction
(SRE),
these
sterol
accounted
for
up
88.29%
of
the
extract.
However,
impact
SRE
on
development
atopic
dermatitis
(AD)
not
yet
investigated.
This
study
investigates
inhibitory
effects
AD
2,4‐dinitrochlorobenzene
(DNCB)‐induced
mouse
model.
Treatment
with
significantly
reduced
score
histopathological
changes
compared
DNCB
group.
The
found
treatment
resulted
decrease
pro‐inflammatory
cytokines
TNF‐α,
CXC‐10,
IL‐12,
IL‐1β
skin
lesions.
Additionally,
immunohistochemical
analysis
revealed
effectively
suppressed
M1
macrophage
infiltration
into
lesion.
Furthermore,
anti‐inflammatory
effect
was
evaluated
LPS
+
INF‐γ
induced
bone
marrow‐derived
macrophages
(BMDMs)
polarization,
inhibited
production
decreased
expression
NLRP3.
increase
p‐AMPK
T172
,
but
had
no
total
AMPK
expression,
after
administration
inhibitor
Compound
C,
partially
reversed.
results
indicate
an
AD,
making
potential
therapeutic
agent
this
disorder.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 27, 2023
Abstract
Psoriasis
is
a
common,
chronic,
and
inflammatory
skin
disease
with
high
burden
on
individuals,
health
systems,
society
worldwide.
With
the
immunological
pathologies
pathogenesis
of
psoriasis
becoming
gradually
revealed,
therapeutic
approaches
for
this
have
gained
revolutionary
progress.
Nevertheless,
mechanisms
less
common
forms
remain
elusive.
Furthermore,
severe
adverse
effects
recurrence
upon
treatment
cessation
should
be
noted
addressed
during
treatment,
which,
however,
has
been
rarely
explored
integration
preliminary
findings.
Therefore,
it
crucial
to
comprehensive
understanding
behind
pathogenesis,
which
might
offer
new
insights
research
lead
more
substantive
progress
in
expand
clinical
options
treatment.
In
review,
we
looked
briefly
introduce
epidemiology,
subtypes,
pathophysiology,
comorbidities
systematically
discuss
signaling
pathways
involving
extracellular
cytokines
intracellular
transmission,
as
well
cross-talk
between
them.
discussion,
also
paid
attention
potential
metabolic
epigenetic
molecular
mechanistic
cascades
related
its
comorbidities.
This
review
outlined
current
psoriasis,
especially
targeted
therapies
novel
strategies,
mechanism
recurrence.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 28, 2022
Psoriasis
is
a
chronic
inflammatory
skin
disease
characterized
by
scaly
indurated
erythema.
This
impairs
patients’
quality
of
life
enormously.
Pathological
findings
demonstrate
proliferation
and
abnormal
differentiation
keratinocytes
massive
infiltration
immune
cells.
The
pathogenesis
psoriasis
complicated.
Among
cells,
dendritic
cells
play
pivotal
role
in
the
development
both
initiation
maintenance
phases.
In
addition,
it
has
been
indicated
that
macrophages
contribute
to
especially
phase,
although
studies
on
are
limited.
this
article,
we
review
roles
psoriasis.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 10, 2024
Macrophages
are
crucial
cells
in
the
human
body's
innate
immunity
and
engaged
a
variety
of
non-inflammatory
reactions.
can
develop
into
two
kinds
when
stimulated
by
distinct
internal
environments:
pro-inflammatory
M1-like
macrophages
anti-inflammatory
M2-type
macrophages.
During
inflammation,
activated
alternatively,
maintaining
reasonably
steady
ratio
is
critical
for
homeostasis
Journal of Inflammation,
Год журнала:
2023,
Номер
20(1)
Опубликована: Окт. 12, 2023
Abstract
When
exposed
to
various
microenvironmental
stimuli,
macrophages
are
highly
plastic
and
primarily
polarized
into
the
pro-inflammatory
M1-type
anti-inflammatory
M2-type,
both
of
which
perform
almost
entirely
opposing
functions.
Due
this
characteristic,
different
functions
at
stages
immunity
inflammation.
Inflammatory
immune
skin
diseases
usually
show
an
imbalance
in
M1/M2
macrophage
ratio,
altering
polarization
phenotype
can
either
make
symptoms
worse
or
better.
Therefore,
review
presents
mechanisms
polarization,
inflammation-related
signaling
pathways
(JAK/STAT,
NF-κB,
PI3K/Akt),
role
inflammatory
(psoriasis,
AD,
SLE,
BD,
etc.)
provide
new
directions
for
basic
clinical
research
related
diseases.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
161, С. 114469 - 114469
Опубликована: Март 2, 2023
Inflammatory
dermatosis
is
characterized
by
persistent
inflammatory
infiltration
and
hard
repair
of
diseased
skin.
As
a
member
the
human
innate
immune
cells,
macrophages
usually
show
different
phenotypes
in
diseases.
The
macrophage
phenotype
(M1/M2)
imbalance
caused
increase
M1
or
decrease
M2
common
dermatosis.
In
recent
years,
with
deepening
research
on
skin
diseases,
more
natural
medicines/traditional
Chinese
medicines
(TCMs),
represented
Shikonin
Angelica
Dahurica,
have
shown
their
therapeutic
effects
affecting
polarization
macrophages.
This
review
introduced
dermatosis,
such
as
psoriasis.
Then
summarized
medicines/TCMs
that
potential
so
far
mechanisms
action
proteins/signal
pathways
involved.
We
found
TCMs
listed
this
are
closely
related
to
theory
five
flavors
four
properties
medicinal,
most
them
bitter,
acrid
sweet.
Bitter
antipyretic,
anti-inflammatory
antibacterial
effects,
which
may
improve
inflammation
infiltration.
Acrid
effect
promoting
blood
circulation,
while
sweet
nourishing.
These
2
accelerate
lesions
conclusion,
we
hope
provide
sufficient
knowledge
for
medicine
development
imbalance.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Окт. 27, 2023
Abstract
Cardiovascular
disease
(CVD)
is
the
leading
cause
of
death
in
world,
with
a
high
incidence
and
youth-oriented
tendency.
RNA
modification
ubiquitous
indispensable
cell,
maintaining
cell
homeostasis
function
by
dynamically
regulating
gene
expression.
Accumulating
evidence
has
revealed
role
aberrant
expression
CVD
caused
dysregulated
modification.
In
this
review,
we
focus
on
nine
common
modifications:
N
6
-methyladenosine
(m
A),
1
5-methylcytosine
5
C),
7
-methylguanosine
G),
4
-acetylcytosine
(ac
pseudouridine
(Ψ),
uridylation,
adenosine-to-inosine
(A-to-I)
editing,
modifications
U34
tRNA
wobble.
We
summarize
key
regulators
their
effects
expression,
such
as
splicing,
maturation,
transport,
stability,
translation.
Then,
based
classification
CVD,
mechanisms
which
occurs
progresses
through
are
discussed.
Potential
therapeutic
strategies,
therapy,
reviewed
these
mechanisms.
Herein,
some
(such
stroke
peripheral
vascular
disease)
not
included
due
to
limited
availability
literature.
Finally,
prospective
applications
challenges
discussed
for
purpose
facilitating
clinical
Moreover,
look
forward
more
studies
exploring
roles
future,
there
substantial
uncultivated
areas
be
explored.
Theranostics,
Год журнала:
2024,
Номер
14(3), С. 1049 - 1064
Опубликована: Янв. 1, 2024
Macrophage-associated
inflammation
and
keratinocytes
excessive
proliferation
inflammatory
cytokines
secretion
induced
by
stimulation
play
an
important
role
in
the
progression
of
psoriasiform
dermatitis.
However,
how
these
two
types
cells
communicate
remains
obscure.
