Urticaria

Nature Reviews Disease Primers, Год журнала: 2022, Номер 8(1)

Опубликована: Сен. 15, 2022

Язык: Английский

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Neutrophilic and eosinophilic dermatoses associated with hematological malignancy

Frontiers in Medicine, Год журнала: 2024, Номер 10

Опубликована: Янв. 5, 2024

Cutaneous manifestations of hematologic malignancy represent both a clinical challenge for the treating physician and pathophysiological model advancing knowledge on individual neoplasms. Indeed, growing body evidence supports concept recurrent molecular defects associating with specific features, as best exemplified by VEXAS. Herein neutrophilic eosinophilic dermatoses potential interest hematologists dermatologists will be reviewed, including subcorneal pustular dermatosis-type IgA pemphigus, eccrine hidradenitis, Sweet’s syndrome well myelodysplasia cutis VEXAS, pyoderma gangrenosum, annular erythema, dermatosis hematological malignancy, Wells cutaneous involvement in hypereosinophilic syndromes. Possible management approaches are discussed each, emphasizing scenarios that require treatment underlying condition to achieve remission at skin level.

Язык: Английский

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Off‐label use of dupilumab in the management of pediatric urticaria vasculitis: A promising therapeutic choice

Pediatric Allergy and Immunology, Год журнала: 2025, Номер 36(2)

Опубликована: Фев. 1, 2025

Язык: Английский

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Atopy in chronic urticaria: an important yet overlooked issue

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 6, 2024

Chronic urticaria (CU) is one of the most common dermatological diseases and has a significant impact on quality life patients. However, pathogenesis this disease remains unclear. Autoimmunity in chronic spontaneous (CSU) received considerable attention been studied previously. Atopy an important characteristic CU; however, it not fully recognized. predisposes individuals to immune responses allergens, leading type 2 inflammation immunoglobulin E (IgE) overproduction. Compared with healthy individuals, patients CU have higher proportion atopy, atopic background correlated clinical characteristics CU. The total IgE levels significantly than those individuals. Although its level that classic allergic diseases, closely related Exogenous auto-allergens, specific IgEs, which are reported, their roles also being studied. Local systemic present This review summarizes current knowledge regarding atopy CU, speculating there subtypes, such as CSU or inducible (CIndU) may be involved These findings provide new perspective for comprehensive understanding features further research pathogenesis.

Язык: Английский

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Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic

Frontiers in Medicine, Год журнала: 2022, Номер 9

Опубликована: Авг. 23, 2022

Cutaneous vasculitides encompass a heterogeneous group of clinicopathological entities, which may occur as single-organ vasculitis the skin or present skin-limited variant systemic (i.e., ANCA-associated vasculitis), and are triggered by various factors, including infections, drugs vaccines. The COVID-19 pandemic has challenged us with variety both disease- vaccine-associated manifestations, vasculitis. Among latter, cutaneous small-vessel vasculitis, previously known leukocytoclastic seems to be most reported in either scenario, i.e., natural infection vaccination. Vasculopathy without true vasculitic changes on histology develops but minority cases, mostly severe/critical patients, appears result endothelial injury due pauci-immune thromboembolic mechanisms. Herein, we provide an overview available literature COVID-19-associated anti-SARS-CoV-2-vaccine-associated Although evidence is limited isolated reports, proportion cases lacking histopathological confirmation, ample overlap pre-pandemic forms shown.

Язык: Английский

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Complement

Arthritis & Rheumatology, Год журнала: 2023, Номер 76(1), С. 1 - 8

Опубликована: Авг. 8, 2023

The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case presented which serum testing for C3 C4 performed to help assess a syndrome with broad differential diagnosis. review includes discussion deficiency states, consumption by characterized immune‐complex formation deposition, usefulness interpretation laboratory tests complement, development drugs targeting specific components the pathway growing number indications.

Язык: Английский

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Urticarial Vasculitis

Immunology and Allergy Clinics of North America, Год журнала: 2024, Номер 44(3), С. 483 - 502

Опубликована: Май 19, 2024

Язык: Английский

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Urinary soluble CD163 is useful as “liquid biopsy” marker in lupus nephritis at both diagnosis and follow-up to predict impending flares

Journal of Translational Autoimmunity, Год журнала: 2024, Номер 9, С. 100244 - 100244

Опубликована: Июнь 20, 2024

Lupus nephritis (LN) diagnosis and follow-up requires noninvasive biomarkers. Therefore, the added value of coupling urinary soluble (s)CD163/creatinuria ratio with serological markers was evaluated in a real-world clinical practice. To this end, monocentric retrospective study conducted 139 SLE patients biopsy-proven having an active LN (LN-A, n = 63 positive SLEDAI-renal score) or inactive (n 76), as well 98 non-renal patients. The sCD163/creatinuria outperformed for predicting LN-A (AUC>0.972; p < 10−4 100 % specificity threshold fixed at 320 ng/mmol), monitoring renal activity allowing prediction impending flares remissions (AUC 0.789, 10−4). elevated spot proteinuria/creatinuria (p 8 × 10−6) 10−3) were risk developing end-stage kidney disease but cannot substitute biopsy to discriminate from other glomerulonephritis. Among 14), anti-dsDNA anti-C1q antibodies (Abs) (AUC>0.750 versus non-LN patients, AUC>0.640 LN-IR patients) best predicted LN-A, higher levels retrieved class III/IV proliferative LN-A. In multivariate logistic regression analysis, remained only statistically significant biomarker predict 0.001). conclusion, compared classical markers, provides additional parameter

Язык: Английский

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A Rare Case of Photo‐Induced Urticarial Vasculitis

Photodermatology Photoimmunology & Photomedicine, Год журнала: 2025, Номер 41(1)

Опубликована: Янв. 1, 2025

We report the case of a 46-year-old, white Caucasian female who presented with 5-year history severe, recurrent episodes immediate photosensitivity. The patient developed pruritic, erythematous rash urticated plaques on exposed body sites. onset was within minutes sun-exposure. Occasionally she experienced constitutional symptoms fatigue and chills. offset variable; would typically resolve hours, but more severe flares could persist for days leaving purple discolouration to skin. Episodes were not limited direct sun-exposure alone also occur cloudy or through windows loose-knit clothing. Furthermore, skin appeared become 'hardened' following each exposure, less sensitivity noted at affected sites number weeks afterwards. Examination revealed well-demarcated, oedematous across her limbs chest striking cut-off where photo-occluded by socks (Figure 1). underwent phototesting monochromator solar stimulator. An response urticarial wheals 300, 320, 370 400 nm indicating photosensitivity UVB, UVA into visible light spectrum. 2a) At 24 h, palpable erythema 300 320 nm. Phototesting simulator (300–400 range) produced wheals. A 5 x cm provocation test administered simulator. 24-h, there wealing. 2b) biopsy taken histology demonstrated extensive leukocytoclasis admixed neutrophils in superficial dermis focal fibrinoid necrosis vessels. Perivascular lymphocytic eosinophilic inflammation visualised mid keeping vasculitis. Further investigations including full blood count, renal liver function normal. IGE significantly elevated (982 kU/L). Inflammatory markers CRP ESR elevated. ANCA, ANA, C3, C4, Cryoglobulins, SPEP, Rheumatoid Factor Anti-CCP all normal limits. Virology screening HBV, HCV HIV negative. Urinalysis presence red cells. Currently, is well-controlled rigorous photoprotective measures mineral based sunscreen tint antihistamines. This presents rare Photo-induced Urticarial Vasculitis (PUV). There paucity data literature describing this unique phenomenon. Solar urticaria (SU) form chronic inducible mean age 35-years. Patients present pruritic moments Diagnosis confirmed phototesting. However, comparison case, SU mirrors that other forms dermal oedema mixed neutrophilic, infiltrate surrounding vasculature [1, 2]. vasculitis (UV) hand stinging, lesions often without an identifiable trigger last least h. It generally classified normocomplementemic versus hypocomplementemic UV distinguished complement levels time acute presentation. Ecchymoses hyperpigmentation may be identified as resolve. Unlike urticaria, will demonstrate findings consistent leukocytoclastic [3]. highlights value raises question whether underreported phenomenon due challenge obtaining timely our investigation patients such this. Due sensitivity, SPF insufficient photoprotection require tinted, protective clothing block light. Antihistamines can prove helpful symptom control. Recent evidence demonstrates positive outcomes use targeted monoclonal antibodies (e.g., omalizumab) remains consideration future [4, 5]. research useful add establish true burden debilitating disease. Study conception design: Eoin Storan, collection: Anna Wolinska, Luke Oonan analysis interpretation results: draft manuscript preparation: Wolinska. All authors reviewed results approved final version manuscript. Written informed consent has been given publication. declare no conflicts interest. Data available request from authors.

Язык: Английский

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When skin and lung meet

European Journal of Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

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