Loss of tolerance to dietary proteins: From mouse models to human model diseases

Immunological Reviews, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

The critical importance of the immunoregulatory mechanisms, which prevent adverse responses to dietary proteins is demonstrated by consequences their failure in two common but distinct human pathological conditions, food allergy and celiac disease. mechanisms tolerance have been extensively studied mouse models extent results mice can be extrapolated humans remains unclear. Here, after summarizing known control oral models, we discuss how monogenic immune disorders associated with on one hand, disease, other represent model diseases gain insight into key pathways that antigens humans. spectrum disorders, dysfunction a single gene, strongly TH2-mediated suggests an important overlap between regulate TH2 IgE mice. In contrast, disease provides unique example link autoimmunity loss antigen.

Язык: Английский

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Genetic landscape of atopic dermatitis

Current Opinion in Allergy and Clinical Immunology, Год журнала: 2024, Номер 24(5), С. 409 - 415

Опубликована: Июнь 24, 2024

This review summarizes recent advances in identifying genetic risk factors for atopic dermatitis and how these associations are being used to explore the causal relationships between potential downstream outcomes.

Язык: Английский

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Maladies auto-inflammatoires et les déficits immunitaires

Perfectionnement en Pédiatrie, Год журнала: 2024, Номер 7(2), С. 2S38 - 2S41

Опубликована: Июнь 1, 2024

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Quoi de neuf en dermatologie pédiatrique ?

Annales de Dermatologie et de Vénéréologie - FMC, Год журнала: 2023, Номер 3(8), С. 8S33 - 8S40

Опубликована: Дек. 1, 2023

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