Biomolecules,
Год журнала:
2023,
Номер
14(1), С. 57 - 57
Опубликована: Дек. 31, 2023
The
combustion
of
fossil
fuels
contributes
to
air
pollution
(AP),
which
was
linked
about
8.79
million
global
deaths
in
2018,
mainly
due
respiratory
and
cardiovascular-related
effects.
Among
these,
particulate
(PM2.5)
stands
out
as
a
major
risk
factor
for
heart
health,
especially
during
vulnerable
phases.
Our
prior
study
showed
that
premature
exposure
1,2-naphthoquinone
(1,2-NQ),
chemical
found
diesel
exhaust
particles
(DEP),
exacerbated
asthma
adulthood.
Moreover,
increased
concentration
1,2-NQ
contributed
airway
inflammation
triggered
by
PM2.5,
employing
neurogenic
pathways
related
the
up-regulation
transient
receptor
potential
vanilloid
1
(TRPV1).
However,
impact
early-life
(1,2-NQ)
on
atrial
fibrillation
(AF)
has
not
yet
been
investigated.
This
aims
investigate
how
inhaling
early
life
affects
autonomic
adrenergic
system
role
played
TRPV1
these
disturbances.
C57Bl/6
neonate
male
mice
were
exposed
(100
nM)
or
its
vehicle
at
6,
8,
10
days
life.
Early
impairs
responses
right
atria
without
markedly
affecting
cholinergic
responses.
ECG
analysis
revealed
altered
rhythmicity
young
mice,
suggesting
sympathetic
nervous
activity.
Furthermore,
affected
β1-adrenergic
agonist-mediated
positive
chronotropism,
prevented
metoprolol,
β1
blocker.
Capsazepine,
blocker
but
TRPC5
blocker,
reversed
1,2-NQ-induced
cardiac
changes.
In
conclusion,
AP
results
an
elevated
developing
dysfunction,
potentially
leading
arrhythmia
age.
European Respiratory Review,
Год журнала:
2024,
Номер
33(172), С. 230249 - 230249
Опубликована: Апрель 30, 2024
Paediatric
populations
are
particularly
vulnerable
to
respiratory
diseases
caused
and
exacerbated
by
aeroallergens,
pollutants
infectious
agents.
Worsening
climate
change
is
expected
increase
the
prevalence
of
aeroallergens
while
amplifying
disease
severity
causing
disproportionate
effects
in
under-resourced
areas.
The
purpose
this
narrative
review
summarise
role
anthropogenic
literature
examining
future
impact
agents
on
paediatric
with
a
focus
equitable
mitigation.
selected
for
discussion
include
pollen,
dust
mites
mould
as
these
prevalent
triggers
asthma
worldwide.
Human
rhinovirus
syncytial
virus
key
viruses
interacting
pollution
primary
causal
viral
disease.
Within
review,
we
present
propensity
synergistically
exacerbate
outline
measures
that
can
ameliorate
morbidity
through
health
equity
lens.
We
support
shifting
from
fossil
fuels
renewable
energy
worldwide,
across
sectors,
means
reducing
increases
morbidity.
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 26, 2024
In
recent
years,
there
has
been
a
global
increase
in
the
prevalence
of
allergic
diseases,
including
rhinitis,
chronic
rhinosinusitis,
asthma,
atopic
dermatitis,
conjunctivitis,
and
food
allergies.
Since
pathogenic
mechanisms
these
diseases
are
not
yet
fully
understood,
targeted
effective
therapies
lacking.
The
NLRP3
inflammasome,
multiprotein
complex
implicated
various
inflammatory
can
be
activated
by
diverse
stimuli.
It
assembles
into
inflammasome
complexes
through
conformational
changes,
initiating
proteolytic
cleavage
dormant
procaspase-1
active
caspase-1
promoting
maturation
cytokines,
IL-1β
IL-18.
Dysfunction
may
serve
as
key
driver
leading
to
pyroptosis
amplifying
local
response.
As
preliminarily
demonstrated,
specific
vesicle
inhibitors
play
refectory
roles
animal
models
it
is
believed
that
potential
therapeutic
agents
for
diseases.
This
review
highlights
progress
research
on
explores
its
contribution
different
types
identifies
promising
clinical
targets
intervention.
Jornal de Pediatria,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
To
assess
the
impact
of
climate
change
and
air
pollution
on
children's
respiratory
health.
Narrative
review
articles
published
in
English,
Portuguese,
French,
Spanish
last
decade
following
databases:
PubMed,
Google
Scholar,
EMBASE,
SciELO.
The
keywords
used
this
search
were:
changes
OR
indoor
pollutants
wildfires
AND
human
health
children
exposome.
Increases
extreme
weather
events,
such
as
heat
waves,
forest
fires,
floods,
droughts,
hurricanes,
dust
storms,
put
system
at
greater
risk.
growing
global
increase
diseases
recent
decades
raises
questions
about
environmental
factors
resulting
from
industrialization,
urbanization,
individual's
Understanding
it
better
is
a
key
point
for
treatment.
Environmental Health Insights,
Год журнала:
2025,
Номер
19
Опубликована: Янв. 1, 2025
Climate
change-induced
flooding
has
caused
public
health
crises
in
Borno
State,
Nigeria,
which
influence
the
increase
of
waterborne
diseases
and
malnutrition.
Flooding
disrupts
water
sanitation
systems,
creating
breeding
grounds
for
such
as
cholera,
malaria,
diarrheal
illnesses.
The
displacement
communities
destruction
agricultural
infrastructure
due
to
further
food
insecurity,
leading
This
paper
examines
interplay
between
flooding,
diseases,
malnutrition
highlighting
urgent
need
climate
adaptation
strategies
strengthened
healthcare
systems
mitigate
these
challenges.
Additionally,
it
highlights
double
burden
conflict
change
where
ongoing
conflicts
impede
efforts
adapt
change.
Finally,
this
outlines
socio-economic
impacts
proposes
interventions
effects
flooding.
Diseases,
Год журнала:
2024,
Номер
12(6), С. 118 - 118
Опубликована: Июнь 3, 2024
According
to
the
definition
provided
by
United
Nations,
“climate
change”
describes
persistent
alterations
in
temperatures
and
weather
trends.
These
may
arise
naturally,
such
as
fluctuations
solar
cycle.
Nonetheless,
since
19th
century,
human
activities
have
emerged
primary
agent
for
climate
change,
primarily
attributed
combustion
of
fossil
fuels
coal,
oil,
gas.
Climate
change
can
potentially
influence
well-being,
agricultural
production,
housing,
safety,
employment
opportunities
all
individuals.
The
immune
system
is
an
important
interface
through
which
global
affects
health.
Extreme
heat,
events
environmental
pollutants
could
impair
both
innate
adaptive
responses,
promoting
inflammation
genomic
instability,
increasing
risk
autoimmune
chronic
inflammatory
diseases.
Moreover,
has
impact
on
soil
gut
microbiome
composition,
further
explain
changes
health
outcomes.
This
narrative
review
aims
explore
disease,
focusing
specifically
its
effects
microbiota.
Understanding
how
these
factors
contribute
development
physical
mental
illness
allow
design
strategies
aimed
at
reducing
negative
pollution
